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A1AI83

- RHAR_ECOK1

UniProt

A1AI83 - RHAR_ECOK1

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Protein

HTH-type transcriptional activator RhaR

Gene
rhaR, Ecok1_38790, APECO1_2562
Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei246 – 2461Interaction with sigma-70 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 21420H-T-H motif By similarityAdd
BLAST
DNA bindingi244 – 26724H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. rhamnose metabolic process Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaR
Alternative name(s):
L-rhamnose operon transcriptional activator RhaR
Gene namesi
Name:rhaR
Ordered Locus Names:Ecok1_38790
ORF Names:APECO1_2562
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282HTH-type transcriptional activator RhaRUniRule annotationPRO_0000292772Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a dimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405955.APECO1_2562.

Structurei

3D structure databases

ProteinModelPortaliA1AI83.
SMRiA1AI83. Positions 24-89, 175-278.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2207.
HOGENOMiHOG000290513.
KOiK02854.
OrthoDBiEOG6Z3KH4.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01533. HTH_type_RhaR.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AI83-1 [UniParc]FASTAAdd to Basket

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MAHQLKLLKD DFFASDQQAV AVADRYPQDV FAEHTHDFCE LVIVWRGNGL    50
HVLNDRPYRI TRGDLFYIHA DDKHSYASVN DLVLQNIIYC PERLKLNLDW 100
QGAIPGFNAS AGQPHWRLGS VGMAQARQVI GQLEHESSQH VPFANEMAEL 150
LFGQLVMLLN RHRYTSDSLP PTSSETLLDK LITRLAASLK SPFALDKFCD 200
EASCSERVLR QQFRQQTGMT INQYLRQVRV CHAQYLLQHS RLLISDISTE 250
CGFEDSNYFS VVFTRETGMT PSQWRHLNSQ KD 282
Length:282
Mass (Da):32,341
Last modified:July 24, 2007 - v2
Checksum:i48DC6942F46DBC88
GO

Sequence cautioni

The sequence ABJ03373.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ03373.1. Different initiation.
RefSeqiYP_859497.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ03373; ABJ03373; APECO1_2562.
GeneIDi4495588.
KEGGiecv:APECO1_2562.
PATRICi18220327. VBIEscCol127180_4373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ03373.1 . Different initiation.
RefSeqi YP_859497.1. NC_008563.1.

3D structure databases

ProteinModelPortali A1AI83.
SMRi A1AI83. Positions 24-89, 175-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_2562.

Protein family/group databases

AraC-XylS Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ03373 ; ABJ03373 ; APECO1_2562 .
GeneIDi 4495588.
KEGGi ecv:APECO1_2562.
PATRICi 18220327. VBIEscCol127180_4373.

Phylogenomic databases

eggNOGi COG2207.
HOGENOMi HOG000290513.
KOi K02854.
OrthoDBi EOG6Z3KH4.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPi MF_01533. HTH_type_RhaR.
InterProi IPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view ]
Pfami PF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view ]
PRINTSi PR00032. HTHARAC.
SMARTi SM00342. HTH_ARAC. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
SSF51182. SSF51182. 1 hit.
PROSITEi PS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRHAR_ECOK1
AccessioniPrimary (citable) accession number: A1AI83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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