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A1AI83

- RHAR_ECOK1

UniProt

A1AI83 - RHAR_ECOK1

Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei246 – 2461Interaction with sigma-70UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi195 – 21420H-T-H motifUniRule annotationAdd
    BLAST
    DNA bindingi244 – 26724H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    2. rhamnose metabolic process Source: UniProtKB-HAMAP
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Rhamnose metabolism, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional activator RhaRUniRule annotation
    Alternative name(s):
    L-rhamnose operon transcriptional activator RhaRUniRule annotation
    Gene namesi
    Name:rhaRUniRule annotation
    Ordered Locus Names:Ecok1_38790
    ORF Names:APECO1_2562
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282HTH-type transcriptional activator RhaRPRO_0000292772Add
    BLAST

    Interactioni

    Subunit structurei

    Binds DNA as a dimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405955.APECO1_2562.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AI83.
    SMRiA1AI83. Positions 24-89, 175-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2207.
    HOGENOMiHOG000290513.
    KOiK02854.
    OrthoDBiEOG6Z3KH4.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    2.60.120.280. 1 hit.
    HAMAPiMF_01533. HTH_type_RhaR.
    InterProiIPR003313. AraC-bd.
    IPR009057. Homeodomain-like.
    IPR018060. HTH_AraC.
    IPR018062. HTH_AraC-typ_CS.
    IPR011051. RmlC_Cupin.
    IPR023699. Tscrpt_act_RhaR.
    IPR020449. Tscrpt_reg_HTH_AraC-type.
    [Graphical view]
    PfamiPF02311. AraC_binding. 1 hit.
    PF12833. HTH_18. 1 hit.
    [Graphical view]
    PRINTSiPR00032. HTHARAC.
    SMARTiSM00342. HTH_ARAC. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    SSF51182. SSF51182. 1 hit.
    PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
    PS01124. HTH_ARAC_FAMILY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1AI83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHQLKLLKD DFFASDQQAV AVADRYPQDV FAEHTHDFCE LVIVWRGNGL    50
    HVLNDRPYRI TRGDLFYIHA DDKHSYASVN DLVLQNIIYC PERLKLNLDW 100
    QGAIPGFNAS AGQPHWRLGS VGMAQARQVI GQLEHESSQH VPFANEMAEL 150
    LFGQLVMLLN RHRYTSDSLP PTSSETLLDK LITRLAASLK SPFALDKFCD 200
    EASCSERVLR QQFRQQTGMT INQYLRQVRV CHAQYLLQHS RLLISDISTE 250
    CGFEDSNYFS VVFTRETGMT PSQWRHLNSQ KD 282
    Length:282
    Mass (Da):32,341
    Last modified:July 24, 2007 - v2
    Checksum:i48DC6942F46DBC88
    GO

    Sequence cautioni

    The sequence ABJ03373.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ03373.1. Different initiation.
    RefSeqiYP_859497.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ03373; ABJ03373; APECO1_2562.
    GeneIDi4495588.
    KEGGiecv:APECO1_2562.
    PATRICi18220327. VBIEscCol127180_4373.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ03373.1 . Different initiation.
    RefSeqi YP_859497.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1AI83.
    SMRi A1AI83. Positions 24-89, 175-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_2562.

    Protein family/group databases

    AraC-XylS Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ03373 ; ABJ03373 ; APECO1_2562 .
    GeneIDi 4495588.
    KEGGi ecv:APECO1_2562.
    PATRICi 18220327. VBIEscCol127180_4373.

    Phylogenomic databases

    eggNOGi COG2207.
    HOGENOMi HOG000290513.
    KOi K02854.
    OrthoDBi EOG6Z3KH4.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    2.60.120.280. 1 hit.
    HAMAPi MF_01533. HTH_type_RhaR.
    InterProi IPR003313. AraC-bd.
    IPR009057. Homeodomain-like.
    IPR018060. HTH_AraC.
    IPR018062. HTH_AraC-typ_CS.
    IPR011051. RmlC_Cupin.
    IPR023699. Tscrpt_act_RhaR.
    IPR020449. Tscrpt_reg_HTH_AraC-type.
    [Graphical view ]
    Pfami PF02311. AraC_binding. 1 hit.
    PF12833. HTH_18. 1 hit.
    [Graphical view ]
    PRINTSi PR00032. HTHARAC.
    SMARTi SM00342. HTH_ARAC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    SSF51182. SSF51182. 1 hit.
    PROSITEi PS00041. HTH_ARAC_FAMILY_1. 1 hit.
    PS01124. HTH_ARAC_FAMILY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRHAR_ECOK1
    AccessioniPrimary (citable) accession number: A1AI83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3