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A1AI83 (RHAR_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional activator RhaR
Alternative name(s):
L-rhamnose operon transcriptional activator RhaR
Gene names
Name:rhaR
Ordered Locus Names:Ecok1_38790
ORF Names:APECO1_2562
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates expression of the rhaSR operon in response to L-rhamnose By similarity. HAMAP-Rule MF_01533

Subunit structure

Binds DNA as a dimer By similarity. HAMAP-Rule MF_01533

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01533.

Sequence similarities

Contains 2 HTH araC/xylS-type DNA-binding domains.

Sequence caution

The sequence ABJ03373.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282HTH-type transcriptional activator RhaR HAMAP-Rule MF_01533
PRO_0000292772

Regions

DNA binding195 – 21420H-T-H motif By similarity
DNA binding244 – 26724H-T-H motif By similarity

Sites

Site2461Interaction with sigma-70 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1AI83 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 48DC6942F46DBC88

FASTA28232,341
        10         20         30         40         50         60 
MAHQLKLLKD DFFASDQQAV AVADRYPQDV FAEHTHDFCE LVIVWRGNGL HVLNDRPYRI 

        70         80         90        100        110        120 
TRGDLFYIHA DDKHSYASVN DLVLQNIIYC PERLKLNLDW QGAIPGFNAS AGQPHWRLGS 

       130        140        150        160        170        180 
VGMAQARQVI GQLEHESSQH VPFANEMAEL LFGQLVMLLN RHRYTSDSLP PTSSETLLDK 

       190        200        210        220        230        240 
LITRLAASLK SPFALDKFCD EASCSERVLR QQFRQQTGMT INQYLRQVRV CHAQYLLQHS 

       250        260        270        280 
RLLISDISTE CGFEDSNYFS VVFTRETGMT PSQWRHLNSQ KD 

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABJ03373.1. Different initiation.
RefSeqYP_859497.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1AI83.
SMRA1AI83. Positions 24-89, 175-278.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_2562.

Protein family/group databases

AraC-XylSSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ03373; ABJ03373; APECO1_2562.
GeneID4495588.
KEGGecv:APECO1_2562.
PATRIC18220327. VBIEscCol127180_4373.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2207.
HOGENOMHOG000290513.
KOK02854.
OrthoDBEOG6Z3KH4.
ProtClustDBPRK13500.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPMF_01533. HTH_type_RhaR.
InterProIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSPR00032. HTHARAC.
SMARTSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
SSF51182. SSF51182. 1 hit.
PROSITEPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRHAR_ECOK1
AccessionPrimary (citable) accession number: A1AI83
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families