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Protein

HTH-type transcriptional activator RhaS

Gene

rhaS

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates expression of the rhaBAD and rhaT operons.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei241 – 2411Interaction with sigma-70UniRule annotation
Sitei250 – 2501Interaction with sigma-70UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi190 – 20920H-T-H motifUniRule annotationAdd
BLAST
DNA bindingi239 – 26224H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. rhamnose metabolic process Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaSUniRule annotation
Alternative name(s):
L-rhamnose operon regulatory protein RhaSUniRule annotation
Gene namesi
Name:rhaSUniRule annotation
Ordered Locus Names:Ecok1_38780
ORF Names:APECO1_2563
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278HTH-type transcriptional activator RhaSPRO_1000068702Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Protein-protein interaction databases

STRINGi405955.APECO1_2563.

Structurei

3D structure databases

ProteinModelPortaliA1AI82.
SMRiA1AI82. Positions 22-83, 170-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2207.
HOGENOMiHOG000290513.
KOiK02855.
OMAiYAIAIEP.
OrthoDBiEOG66XBBN.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
HAMAPiMF_01534. HTH_type_RhaS.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AI82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVLHSVDFF PSGNASVAIE PRLPQADFPE HHHDFHEIVI VEHGTGIHVF
60 70 80 90 100
NGQPYTITGG TVCFVRDHDR HLYEHTDNLC LTNVLYRSPD RFQFLAGLNQ
110 120 130 140 150
LLPQEQDGQY PSHWRVNHSV LQQVRQLVAQ MEQQEEENDL PSTASREILF
160 170 180 190 200
MQLLLLLRKS SLQENLENSA SRLNLLLAWL EDHFADEVNW DAVADQFSLS
210 220 230 240 250
LRTLHRQLKQ KTGLTPQRYL NRLRLMKARH LLRHSEASVT DIAYRCGFSD
260 270
SNHFSTLFRR EFNWSPRDIR QGRDGFLQ
Length:278
Mass (Da):32,402
Last modified:January 23, 2007 - v1
Checksum:i71E981876A6F21A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ03372.1.
RefSeqiYP_859496.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ03372; ABJ03372; APECO1_2563.
GeneIDi4495587.
KEGGiecv:APECO1_2563.
PATRICi18220325. VBIEscCol127180_4372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ03372.1.
RefSeqiYP_859496.1. NC_008563.1.

3D structure databases

ProteinModelPortaliA1AI82.
SMRiA1AI82. Positions 22-83, 170-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405955.APECO1_2563.

Protein family/group databases

AraC-XylSSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ03372; ABJ03372; APECO1_2563.
GeneIDi4495587.
KEGGiecv:APECO1_2563.
PATRICi18220325. VBIEscCol127180_4372.

Phylogenomic databases

eggNOGiCOG2207.
HOGENOMiHOG000290513.
KOiK02855.
OMAiYAIAIEP.
OrthoDBiEOG66XBBN.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
HAMAPiMF_01534. HTH_type_RhaS.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRHAS_ECOK1
AccessioniPrimary (citable) accession number: A1AI82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.