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A1AI82

- RHAS_ECOK1

UniProt

A1AI82 - RHAS_ECOK1

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Protein

HTH-type transcriptional activator RhaS

Gene
rhaS, Ecok1_38780, APECO1_2563
Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Activates expression of the rhaBAD and rhaT operons By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei241 – 2411Interaction with sigma-70 By similarity
Sitei250 – 2501Interaction with sigma-70 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi190 – 20920H-T-H motif By similarityAdd
BLAST
DNA bindingi239 – 26224H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. rhamnose metabolic process Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaS
Alternative name(s):
L-rhamnose operon regulatory protein RhaS
Gene namesi
Name:rhaS
Ordered Locus Names:Ecok1_38780
ORF Names:APECO1_2563
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278HTH-type transcriptional activator RhaSUniRule annotationPRO_1000068702Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a dimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405955.APECO1_2563.

Structurei

3D structure databases

ProteinModelPortaliA1AI82.
SMRiA1AI82. Positions 22-83, 170-274.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2207.
HOGENOMiHOG000290513.
KOiK02855.
OMAiYEETAID.
OrthoDBiEOG66XBBN.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
HAMAPiMF_01534. HTH_type_RhaS.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AI82-1 [UniParc]FASTAAdd to Basket

« Hide

MTVLHSVDFF PSGNASVAIE PRLPQADFPE HHHDFHEIVI VEHGTGIHVF    50
NGQPYTITGG TVCFVRDHDR HLYEHTDNLC LTNVLYRSPD RFQFLAGLNQ 100
LLPQEQDGQY PSHWRVNHSV LQQVRQLVAQ MEQQEEENDL PSTASREILF 150
MQLLLLLRKS SLQENLENSA SRLNLLLAWL EDHFADEVNW DAVADQFSLS 200
LRTLHRQLKQ KTGLTPQRYL NRLRLMKARH LLRHSEASVT DIAYRCGFSD 250
SNHFSTLFRR EFNWSPRDIR QGRDGFLQ 278
Length:278
Mass (Da):32,402
Last modified:January 23, 2007 - v1
Checksum:i71E981876A6F21A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ03372.1.
RefSeqiYP_859496.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ03372; ABJ03372; APECO1_2563.
GeneIDi4495587.
KEGGiecv:APECO1_2563.
PATRICi18220325. VBIEscCol127180_4372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ03372.1 .
RefSeqi YP_859496.1. NC_008563.1.

3D structure databases

ProteinModelPortali A1AI82.
SMRi A1AI82. Positions 22-83, 170-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_2563.

Protein family/group databases

AraC-XylS Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ03372 ; ABJ03372 ; APECO1_2563 .
GeneIDi 4495587.
KEGGi ecv:APECO1_2563.
PATRICi 18220325. VBIEscCol127180_4372.

Phylogenomic databases

eggNOGi COG2207.
HOGENOMi HOG000290513.
KOi K02855.
OMAi YEETAID.
OrthoDBi EOG66XBBN.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
HAMAPi MF_01534. HTH_type_RhaS.
InterProi IPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view ]
Pfami PF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view ]
PRINTSi PR00032. HTHARAC.
SMARTi SM00342. HTH_ARAC. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEi PS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRHAS_ECOK1
AccessioniPrimary (citable) accession number: A1AI82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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