A1AHX2 (A1AHX2_ECOK1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenylate cyclase RuleBase RU000604
EC=4.6.1.1 RuleBase RU000604

Gene names

Name:	cyaA EMBL ABJ03262.1
Ordered Locus Names:	Ecok1_37680
ORF Names:	APECO1_2672 EMBL ABJ03262.1

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	829 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate. RuleBase RU000604
Subcellular location	Cytoplasm By similarity RuleBase RU000604.
Sequence similarities	Belongs to the adenylyl cyclase class-1 family. RuleBase RU004184

Ontologies

Keywords
Biological process	cAMP biosynthesis RuleBase RU000604
Molecular function	Lyase RuleBase RU000604
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenylate cyclase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1AHX2 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: FF8C26ECB46FFD31	FASTA	829	95,368
	10 20 30 40 50 60 MDRALAAMGP AFQQVYSLLP TLLHYHHPLM PGYLDGNVPK GICLYTPDET QRHYLNELEL 70 80 90 100 110 120 YRGMSVQDPP KGELPITGVY TMGSTSSVGQ SCSSDLDIWV CHQSWLDSEE RQLLQRKCSL 130 140 150 160 170 180 LESWAASLGV EVSFFLIDEN RFRHNESGSL GGEDCGSTQH ILLLDEFYRT AVRLAGKRIL 190 200 210 220 230 240 WNMVPCDEEE HYDDYVMTLY AQGVLTPNEW LDLGGLSSLS AEEYFGASLW QLYKSIDSPY 250 260 270 280 290 300 KAVLKTLLLE AYSWEYPNPR LLAKDIKQRL HDGEIVSFGL DPYCMMLERV TEYLTAIEDF 310 320 330 340 350 360 TRLDLVRRCF YLKVCEKLSR ERACVGWRRE VLSQLVKEWE WDDARLAMLD NRANWKIDQV 370 380 390 400 410 420 REAHNELLDA MMQSYRNLIR FARRNNLSVS ASPQDIGVLT RKLYAAFEAL PGKVTLVNPQ 430 440 450 460 470 480 ISPDLSEPNL TFIYVPPGRA NRSGWYLYNR APNIESIISH QPLEYNRYLN KLVAWAWFNG 490 500 510 520 530 540 LLTSRTRLYI KGNGIVDLPK LQEMVADVSH HFPLRLPAPT PKALYSPCEI RHLAIIVNLE 550 560 570 580 590 600 YDPTAAFRNQ VVHFDFRKLD VFSFGENQNC LVGSVDLLYR NSWNEVRTLH FNGEQSMIEA 610 620 630 640 650 660 LKTILGKMHQ DAAPPDSVEV FCYSQHLRGL IRTRVQQLVS ECIELRLSST RQETGRFKAL 670 680 690 700 710 720 RVSGQTWGLF FERLNVSVQK LENAIEFYGA ISHNKLHGLS VQVETNHVKL PAVVDGFASE 730 740 750 760 770 780 GIIQFFFEET QDENGFNIYI LDESNRVEVY HHCEGSKEEL VRDVSRFYSS SHDRFTYGSS 790 800 810 820 FINFNLPQFY QIVKVDGREQ VIPFRTKSIG NMPPANQEHD APLLQQYFS

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed: 17293413] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABJ03262.1.
RefSeq	YP_859386.2. NC_008563.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1AHX2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000035453; EBESCP00000033970; EBESCG00000034503.
GeneID	4495458.
GenomeReviews	Gene locus Ecok1_37680 in contig CP000468_GR.
KEGG	ecv:APECO1_2672.
PATRIC	18220071. VBIEscCol127180_4250.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3072.
GeneTree	EBGT00050000010325.
HOGENOM	HBG678054.
OMA	LWQLYKG.
ProtClustDB	PRK09450.
Family and domain databases
InterPro	IPR000274. Adenylate_cyclase_1. IPR024686. Adenylate_cyclase_1_CS. IPR024685. Adenylate_cyclase_1_N. [Graphical view]
KO	K05851.
Pfam	PF12633. Adenyl_cycl_N. 1 hit. PF01295. Adenylate_cycl. 1 hit. [Graphical view]
PIRSF	PIRSF001444. Adenylate_cycl. 1 hit.
PROSITE	PS01092. ADENYLATE_CYCLASE_1_1. 1 hit. PS01093. ADENYLATE_CYCLASE_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1AHX2_ECOK1

Accession

Primary (citable) accession number: A1AHX2

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)