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A1AHH2 (SLMA_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoid occlusion factor SlmA
Gene names
Name:slmA
Ordered Locus Names:Ecok1_36180
ORF Names:APECO1_2820
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions By similarity. HAMAP-Rule MF_01839

Subunit structure

Homodimer By similarity. Interacts with FtsZ By similarity. HAMAP-Rule MF_01839

Subcellular location

Cytoplasmnucleoid By similarity HAMAP-Rule MF_01839.

Sequence similarities

Belongs to the nucleoid occlusion factor SlmA family.

Contains 1 HTH tetR-type DNA-binding domain.

Sequence caution

The sequence ABJ03112.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCytoplasm
   DomainCoiled coil
   LigandDNA-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of barrier septum assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentbacterial nucleoid

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Nucleoid occlusion factor SlmA HAMAP-Rule MF_01839
PRO_0000413758

Regions

Domain10 – 7061HTH tetR-type
DNA binding33 – 5220H-T-H motif By similarity
Coiled coil117 – 14428 Potential

Sequences

Sequence LengthMass (Da)Tools
A1AHH2 [UniParc].

Last modified November 16, 2011. Version 2.
Checksum: C78D00E2875B1F39

FASTA19822,806
        10         20         30         40         50         60 
MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR HFPSKTRMFD 

        70         80         90        100        110        120 
SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLLLGFGE RNPGLTRILT GHALMFEQDR 

       130        140        150        160        170        180 
LQGRINQLFE RIEAQLRQVL REKRMREGEG YATDETLLAS QILAFCEGML SRFVRSEFKY 

       190 
RPTDDFDARW PLIAAQLQ 

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABJ03112.1. Different initiation.
RefSeqYP_859236.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1AHH2.
SMRA1AHH2. Positions 10-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_2820.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ03112; ABJ03112; APECO1_2820.
GeneID4492600.
KEGGecv:APECO1_2820.
PATRIC18219727. VBIEscCol127180_4089.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1309.
HOGENOMHOG000266053.
KOK05501.
OrthoDBEOG6G7R3C.

Family and domain databases

Gene3D1.10.357.10. 1 hit.
HAMAPMF_01839. NO_factor_SlmA.
InterProIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSLMA_ECOK1
AccessionPrimary (citable) accession number: A1AHH2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 14, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families