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A1AHH2

- SLMA_ECOK1

UniProt

A1AHH2 - SLMA_ECOK1

Protein

Nucleoid occlusion factor SlmA

Gene

slmA

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi33 – 5220H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. negative regulation of barrier septum assembly Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoid occlusion factor SlmAUniRule annotation
    Gene namesi
    Name:slmAUniRule annotation
    Ordered Locus Names:Ecok1_36180
    ORF Names:APECO1_2820
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Cytoplasmnucleoid UniRule annotation

    GO - Cellular componenti

    1. bacterial nucleoid Source: UniProtKB-HAMAP
    2. cytoplasm Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Nucleoid occlusion factor SlmAPRO_0000413758Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with FtsZ.UniRule annotation

    Protein-protein interaction databases

    STRINGi405955.APECO1_2820.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AHH2.
    SMRiA1AHH2. Positions 10-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 7061HTH tetR-typeUniRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili117 – 14428UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation
    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000266053.
    KOiK05501.
    OrthoDBiEOG6G7R3C.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_01839. NO_factor_SlmA.
    InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1AHH2-1 [UniParc]FASTAAdd to Basket

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    MAEKQTAKRN RREEILQSLA LMLESSDGSQ RITTAKLAAS VGVSEAALYR    50
    HFPSKTRMFD SLIEFIEDSL ITRINLILKD EKDTTARLRL IVLLLLGFGE 100
    RNPGLTRILT GHALMFEQDR LQGRINQLFE RIEAQLRQVL REKRMREGEG 150
    YATDETLLAS QILAFCEGML SRFVRSEFKY RPTDDFDARW PLIAAQLQ 198
    Length:198
    Mass (Da):22,806
    Last modified:November 16, 2011 - v2
    Checksum:iC78D00E2875B1F39
    GO

    Sequence cautioni

    The sequence ABJ03112.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ03112.1. Different initiation.
    RefSeqiYP_859236.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ03112; ABJ03112; APECO1_2820.
    GeneIDi4492600.
    KEGGiecv:APECO1_2820.
    PATRICi18219727. VBIEscCol127180_4089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ03112.1 . Different initiation.
    RefSeqi YP_859236.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1AHH2.
    SMRi A1AHH2. Positions 10-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_2820.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ03112 ; ABJ03112 ; APECO1_2820 .
    GeneIDi 4492600.
    KEGGi ecv:APECO1_2820.
    PATRICi 18219727. VBIEscCol127180_4089.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000266053.
    KOi K05501.
    OrthoDBi EOG6G7R3C.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_01839. NO_factor_SlmA.
    InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSLMA_ECOK1
    AccessioniPrimary (citable) accession number: A1AHH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3