A1AGG1 (FIS_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-binding protein fis

Gene names

Name:	fis
Ordered Locus Names:	Ecok1_32570
ORF Names:	APECO1_3177

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters By similarity. HAMAP-Rule MF_00166
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transcriptional regulatory fis family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	DNA-binding protein fis HAMAP-Rule MF_00166		PRO_1000023323
Regions
	DNA binding	74 – 93	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1AGG1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 2E339BFCFCDB163C	FASTA	98	11,240
	10 20 30 40 50 60 MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL YELVLAEVEQ 70 80 90 PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABJ02751.1.
RefSeq	YP_858875.1. NC_008563.1.
3D structure databases
ProteinModelPortal	A1AGG1.
SMR	A1AGG1. Positions 1-98.
ModBase	Search...
Protein-protein interaction databases
STRING	405955.APECO1_3177.
Proteomic databases
PRIDE	A1AGG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ02751; ABJ02751; APECO1_3177.
GeneID	4491874.
KEGG	ecv:APECO1_3177.
PATRIC	18218894. VBIEscCol127180_3682.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2901.
HOGENOM	HOG000256331.
KO	K03557.
OMA	HNQTRAA.
ProtClustDB	PRK00430.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
HAMAP	MF_00166. DNA-binding_Fis.
InterPro	IPR005412. Fis_DNA-bd. IPR009057. Homeodomain-like. IPR002197. HTH_Fis. [Graphical view]
Pfam	PF02954. HTH_8. 1 hit. [Graphical view]
PIRSF	PIRSF002097. DNA-binding_Fis. 1 hit.
PRINTS	PR01591. DNABINDNGFIS. PR01590. HTHFIS.
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FIS_ECOK1

Accession

Primary (citable) accession number: A1AGG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program