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A1AGG1

- FIS_ECOK1

UniProt

A1AGG1 - FIS_ECOK1

Protein

DNA-binding protein Fis

Gene

fis

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi74 – 9320H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-binding protein FisUniRule annotation
    Gene namesi
    Name:fisUniRule annotation
    Ordered Locus Names:Ecok1_32570
    ORF Names:APECO1_3177
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9898DNA-binding protein FisPRO_1000023323Add
    BLAST

    Proteomic databases

    PRIDEiA1AGG1.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405955.APECO1_3177.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AGG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transcriptional regulatory Fis family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2901.
    HOGENOMiHOG000256331.
    KOiK03557.
    OMAiHNQTRAA.
    OrthoDBiEOG67HJXZ.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    HAMAPiMF_00166. DNA_binding_Fis.
    InterProiIPR005412. Fis_DNA-bd.
    IPR009057. Homeodomain-like.
    IPR002197. HTH_Fis.
    [Graphical view]
    PfamiPF02954. HTH_8. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002097. DNA-binding_Fis. 1 hit.
    PRINTSiPR01591. DNABINDNGFIS.
    PR01590. HTHFIS.
    SUPFAMiSSF46689. SSF46689. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1AGG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL   50
    YELVLAEVEQ PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN 98
    Length:98
    Mass (Da):11,240
    Last modified:January 23, 2007 - v1
    Checksum:i2E339BFCFCDB163C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ02751.1.
    RefSeqiYP_858875.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ02751; ABJ02751; APECO1_3177.
    GeneIDi4491874.
    KEGGiecv:APECO1_3177.
    PATRICi18218894. VBIEscCol127180_3682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ02751.1 .
    RefSeqi YP_858875.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1AGG1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_3177.

    Proteomic databases

    PRIDEi A1AGG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ02751 ; ABJ02751 ; APECO1_3177 .
    GeneIDi 4491874.
    KEGGi ecv:APECO1_3177.
    PATRICi 18218894. VBIEscCol127180_3682.

    Phylogenomic databases

    eggNOGi COG2901.
    HOGENOMi HOG000256331.
    KOi K03557.
    OMAi HNQTRAA.
    OrthoDBi EOG67HJXZ.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    HAMAPi MF_00166. DNA_binding_Fis.
    InterProi IPR005412. Fis_DNA-bd.
    IPR009057. Homeodomain-like.
    IPR002197. HTH_Fis.
    [Graphical view ]
    Pfami PF02954. HTH_8. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002097. DNA-binding_Fis. 1 hit.
    PRINTSi PR01591. DNABINDNGFIS.
    PR01590. HTHFIS.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFIS_ECOK1
    AccessioniPrimary (citable) accession number: A1AGG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3