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Protein

DNA-binding protein Fis

Gene

fis

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi74 – 9320H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein FisUniRule annotation
Gene namesi
Name:fisUniRule annotation
Ordered Locus Names:Ecok1_32570
ORF Names:APECO1_3177
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898DNA-binding protein FisPRO_1000023323Add
BLAST

Proteomic databases

PRIDEiA1AGG1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1AGG1.
SMRiA1AGG1. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transcriptional regulatory Fis family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2901.
HOGENOMiHOG000256331.
KOiK03557.
OMAiMSDNANL.
OrthoDBiEOG67HJXZ.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00166. DNA_binding_Fis.
InterProiIPR005412. Fis_DNA-bd.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
[Graphical view]
PIRSFiPIRSF002097. DNA-binding_Fis. 1 hit.
PRINTSiPR01591. DNABINDNGFIS.
PR01590. HTHFIS.
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AGG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL
60 70 80 90
YELVLAEVEQ PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN
Length:98
Mass (Da):11,240
Last modified:January 23, 2007 - v1
Checksum:i2E339BFCFCDB163C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ02751.1.
RefSeqiWP_000462905.1. NC_008563.1.
YP_858875.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ02751; ABJ02751; APECO1_3177.
GeneIDi8911232.
KEGGiecv:APECO1_3177.
PATRICi18218894. VBIEscCol127180_3682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ02751.1.
RefSeqiWP_000462905.1. NC_008563.1.
YP_858875.1. NC_008563.1.

3D structure databases

ProteinModelPortaliA1AGG1.
SMRiA1AGG1. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA1AGG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ02751; ABJ02751; APECO1_3177.
GeneIDi8911232.
KEGGiecv:APECO1_3177.
PATRICi18218894. VBIEscCol127180_3682.

Phylogenomic databases

eggNOGiCOG2901.
HOGENOMiHOG000256331.
KOiK03557.
OMAiMSDNANL.
OrthoDBiEOG67HJXZ.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00166. DNA_binding_Fis.
InterProiIPR005412. Fis_DNA-bd.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
[Graphical view]
PIRSFiPIRSF002097. DNA-binding_Fis. 1 hit.
PRINTSiPR01591. DNABINDNGFIS.
PR01590. HTHFIS.
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFIS_ECOK1
AccessioniPrimary (citable) accession number: A1AGG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.