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A1AGG1

- FIS_ECOK1

UniProt

A1AGG1 - FIS_ECOK1

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Protein
DNA-binding protein Fis
Gene
fis, Ecok1_32570, APECO1_3177
Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi74 – 9320H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein Fis
Gene namesi
Name:fis
Ordered Locus Names:Ecok1_32570
ORF Names:APECO1_3177
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898DNA-binding protein FisUniRule annotation
PRO_1000023323Add
BLAST

Proteomic databases

PRIDEiA1AGG1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405955.APECO1_3177.

Structurei

3D structure databases

ProteinModelPortaliA1AGG1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2901.
HOGENOMiHOG000256331.
KOiK03557.
OMAiHNQTRAA.
OrthoDBiEOG67HJXZ.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00166. DNA_binding_Fis.
InterProiIPR005412. Fis_DNA-bd.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
[Graphical view]
PIRSFiPIRSF002097. DNA-binding_Fis. 1 hit.
PRINTSiPR01591. DNABINDNGFIS.
PR01590. HTHFIS.
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AGG1-1 [UniParc]FASTAAdd to Basket

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MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL   50
YELVLAEVEQ PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN 98
Length:98
Mass (Da):11,240
Last modified:January 23, 2007 - v1
Checksum:i2E339BFCFCDB163C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ02751.1.
RefSeqiYP_858875.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ02751; ABJ02751; APECO1_3177.
GeneIDi4491874.
KEGGiecv:APECO1_3177.
PATRICi18218894. VBIEscCol127180_3682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ02751.1 .
RefSeqi YP_858875.1. NC_008563.1.

3D structure databases

ProteinModelPortali A1AGG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_3177.

Proteomic databases

PRIDEi A1AGG1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ02751 ; ABJ02751 ; APECO1_3177 .
GeneIDi 4491874.
KEGGi ecv:APECO1_3177.
PATRICi 18218894. VBIEscCol127180_3682.

Phylogenomic databases

eggNOGi COG2901.
HOGENOMi HOG000256331.
KOi K03557.
OMAi HNQTRAA.
OrthoDBi EOG67HJXZ.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
HAMAPi MF_00166. DNA_binding_Fis.
InterProi IPR005412. Fis_DNA-bd.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
[Graphical view ]
Pfami PF02954. HTH_8. 1 hit.
[Graphical view ]
PIRSFi PIRSF002097. DNA-binding_Fis. 1 hit.
PRINTSi PR01591. DNABINDNGFIS.
PR01590. HTHFIS.
SUPFAMi SSF46689. SSF46689. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFIS_ECOK1
AccessioniPrimary (citable) accession number: A1AGG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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