Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1AGG1 (FIS_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-binding protein Fis
Gene names
Name:fis
Ordered Locus Names:Ecok1_32570
ORF Names:APECO1_3177
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters By similarity. HAMAP-Rule MF_00166

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00166

Sequence similarities

Belongs to the transcriptional regulatory Fis family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898DNA-binding protein Fis HAMAP-Rule MF_00166
PRO_1000023323

Regions

DNA binding74 – 9320H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
A1AGG1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 2E339BFCFCDB163C

FASTA9811,240
        10         20         30         40         50         60 
MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL YELVLAEVEQ 

        70         80         90 
PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN 

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABJ02751.1.
RefSeqYP_858875.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1AGG1.
SMRA1AGG1. Positions 1-98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_3177.

Proteomic databases

PRIDEA1AGG1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ02751; ABJ02751; APECO1_3177.
GeneID4491874.
KEGGecv:APECO1_3177.
PATRIC18218894. VBIEscCol127180_3682.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2901.
HOGENOMHOG000256331.
KOK03557.
OMAMSDNANL.
OrthoDBEOG67HJXZ.
ProtClustDBPRK00430.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
HAMAPMF_00166. DNA_binding_Fis.
InterProIPR005412. Fis_DNA-bd.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
[Graphical view]
PfamPF02954. HTH_8. 1 hit.
[Graphical view]
PIRSFPIRSF002097. DNA-binding_Fis. 1 hit.
PRINTSPR01591. DNABINDNGFIS.
PR01590. HTHFIS.
SUPFAMSSF46689. SSF46689. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFIS_ECOK1
AccessionPrimary (citable) accession number: A1AGG1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families