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Protein

Monofunctional biosynthetic peptidoglycan transglycosylase

Gene

mtgA

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Pathway:ipeptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Monofunctional biosynthetic peptidoglycan transglycosylaseUniRule annotation (EC:2.4.2.-UniRule annotation)
Short name:
Monofunctional TGaseUniRule annotation
Gene namesi
Name:mtgAUniRule annotation
Ordered Locus Names:Ecok1_32050
ORF Names:APECO1_3227
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Monofunctional biosynthetic peptidoglycan transglycosylasePRO_1000017304Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1AGA9.
SMRiA1AGA9. Positions 62-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0744.
HOGENOMiHOG000288117.
KOiK03814.
OMAiQISAWLS.
OrthoDBiEOG6HMXCD.

Family and domain databases

HAMAPiMF_00766. Mono_pep_trsgly.
InterProiIPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Mono_pep_trsgly.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AGA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSRLTVFS FVRRFLLRLM VVLAIFWGGG IALFSVAPVP FSAVMVERQV
60 70 80 90 100
SAWLHGNFRY VAHSDWVSMD QISPWMGLAV IAAEDQKFPE HWGFDVASIE
110 120 130 140 150
QALAHNERNE NRIRGASTIS QQTAKNLFLW DGRSWVRKGL EAGLTLGIET
160 170 180 190 200
VWSKKRILTV YLNIAEFGDG VFGVEAAAQR YFHKPASKLT RSEAALLAAV
210 220 230 240
LPNPLRFKVS APSGYVRSRQ AWILRQMYQL GGEPFMQQHQ LD
Length:242
Mass (Da):27,340
Last modified:January 23, 2007 - v1
Checksum:i5DE02D11E4E96E56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ02699.1.
RefSeqiWP_000047069.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ02699; ABJ02699; APECO1_3227.
KEGGiecv:APECO1_3227.
PATRICi18218779. VBIEscCol127180_3625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ02699.1.
RefSeqiWP_000047069.1. NC_008563.1.

3D structure databases

ProteinModelPortaliA1AGA9.
SMRiA1AGA9. Positions 62-242.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ02699; ABJ02699; APECO1_3227.
KEGGiecv:APECO1_3227.
PATRICi18218779. VBIEscCol127180_3625.

Phylogenomic databases

eggNOGiCOG0744.
HOGENOMiHOG000288117.
KOiK03814.
OMAiQISAWLS.
OrthoDBiEOG6HMXCD.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

HAMAPiMF_00766. Mono_pep_trsgly.
InterProiIPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Mono_pep_trsgly.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMTGA_ECOK1
AccessioniPrimary (citable) accession number: A1AGA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.