A1AGA9 (MTGA_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Monofunctional biosynthetic peptidoglycan transglycosylase
Short name=Monofunctional TGase
EC=2.4.2.-

Gene names

Name:	mtgA
Ordered Locus Names:	Ecok1_32050
ORF Names:	APECO1_3227

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP-Rule MF_00766
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00766
Subcellular location	Cell membrane; Single-pass membrane protein Potential HAMAP-Rule MF_00766.
Sequence similarities	Belongs to the glycosyltransferase 51 family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan-based cell wall Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transferase activity, transferring pentosyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Monofunctional biosynthetic peptidoglycan transglycosylase HAMAP-Rule MF_00766		PRO_1000017304
Regions
	Transmembrane	19 – 39	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A1AGA9 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 5DE02D11E4E96E56	FASTA	242	27,340
	10 20 30 40 50 60 MSKSRLTVFS FVRRFLLRLM VVLAIFWGGG IALFSVAPVP FSAVMVERQV SAWLHGNFRY 70 80 90 100 110 120 VAHSDWVSMD QISPWMGLAV IAAEDQKFPE HWGFDVASIE QALAHNERNE NRIRGASTIS 130 140 150 160 170 180 QQTAKNLFLW DGRSWVRKGL EAGLTLGIET VWSKKRILTV YLNIAEFGDG VFGVEAAAQR 190 200 210 220 230 240 YFHKPASKLT RSEAALLAAV LPNPLRFKVS APSGYVRSRQ AWILRQMYQL GGEPFMQQHQ LD

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABJ02699.1.
RefSeq	YP_858823.1. NC_008563.1.
3D structure databases
ProteinModelPortal	A1AGA9.
SMR	A1AGA9. Positions 62-242.
ModBase	Search...
Protein-protein interaction databases
STRING	405955.APECO1_3227.
Protein family/group databases
CAZy	GT51. Glycosyltransferase Family 51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ02699; ABJ02699; APECO1_3227.
GeneID	4491393.
KEGG	ecv:APECO1_3227.
PATRIC	18218779. VBIEscCol127180_3625.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0744.
HOGENOM	HOG000288117.
KO	K03814.
OMA	QISAWLS.
ProtClustDB	PRK00056.
Enzyme and pathway databases
UniPathway	UPA00219.
Family and domain databases
HAMAP	MF_00766. Mono_pep_trsgly.
InterPro	IPR001264. Glyco_trans_51. IPR011812. Mono_pep_trsgly. [Graphical view]
Pfam	PF00912. Transgly. 1 hit. [Graphical view]
TIGRFAMs	TIGR02070. mono_pep_trsgly. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTGA_ECOK1

Accession

Primary (citable) accession number: A1AGA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program