Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1AEP9 (NORR_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anaerobic nitric oxide reductase transcription regulator NorR
Gene names
Name:norR
Ordered Locus Names:Ecok1_26450
ORF Names:APECO1_3817
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54 By similarity. HAMAP-Rule MF_01314

Pathway

Nitrogen metabolism; nitric oxide reduction. HAMAP-Rule MF_01314

Sequence similarities

Contains 1 sigma-54 factor interaction domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Anaerobic nitric oxide reductase transcription regulator NorR HAMAP-Rule MF_01314
PRO_0000305620

Regions

Domain187 – 416230Sigma-54 factor interaction
Nucleotide binding215 – 2228ATP Potential
Nucleotide binding278 – 28710ATP Potential
DNA binding479 – 49820H-T-H motif By similarity

Amino acid modifications

Modified residue5714-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1AEP9 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 7A0FEB53E863FE5A

FASTA50455,186
        10         20         30         40         50         60 
MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ FIPLAIDGLA 

        70         80         90        100        110        120 
KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG LIPGQESLKV HACVGLPLFA 

       130        140        150        160        170        180 
GQNLIGALTL DGMQPDQFDV FSDEELRLIA ALAAGALSNA LLIEQLESQN MLPGDAAPFE 

       190        200        210        220        230        240 
AVKQTQMIGL SPGMTQLKKE IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV 

       250        260        270        280        290        300 
YLNCAALPES VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL 

       310        320        330        340        350        360 
RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV FPLSVPPLRE 

       370        380        390        400        410        420 
RGDDVILLAG YFCEQCRLRL GLSRVVLSAG ARNLLQHYNF PGNVRELEHA IHRAVVLSRA 

       430        440        450        460        470        480 
TRSGDEVILE AQHFAFPEVT LPPPEAAAVP VVKQNLREAT EAFQRETIRQ ALAQNHHNWA 

       490        500 
ACARMLETDV ANLHRLAKRL GLKD 

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABJ02139.1.
RefSeqYP_853928.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1AEP9.
SMRA1AEP9. Positions 185-432, 456-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_3817.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ02139; ABJ02139; APECO1_3817.
GeneID4494837.
KEGGecv:APECO1_3817.
PATRIC18217543. VBIEscCol127180_3015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3604.
HOGENOMHOG000058487.
KOK12266.
OMAHSCIGLP.
OrthoDBEOG6WHNMG.

Enzyme and pathway databases

UniPathwayUPA00638.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01314. NorR.
InterProIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR009057. Homeodomain-like.
IPR023944. NorR.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamPF01590. GAF. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNORR_ECOK1
AccessionPrimary (citable) accession number: A1AEP9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways