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A1AEP9

- NORR_ECOK1

UniProt

A1AEP9 - NORR_ECOK1

Protein

Anaerobic nitric oxide reductase transcription regulator NorR

Gene

norR

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi215 – 2228ATPUniRule annotation
    Nucleotide bindingi278 – 28710ATPUniRule annotation
    DNA bindingi479 – 49820H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phosphorelay signal transduction system Source: UniProtKB-HAMAP
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaerobic nitric oxide reductase transcription regulator NorRUniRule annotation
    Gene namesi
    Name:norRUniRule annotation
    Ordered Locus Names:Ecok1_26450
    ORF Names:APECO1_3817
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Anaerobic nitric oxide reductase transcription regulator NorRPRO_0000305620Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei57 – 5714-aspartylphosphateUniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi405955.APECO1_3817.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AEP9.
    SMRiA1AEP9. Positions 185-432, 456-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini187 – 416230Sigma-54 factor interactionUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 sigma-54 factor interaction domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3604.
    HOGENOMiHOG000058487.
    KOiK12266.
    OMAiHSCIGLP.
    OrthoDBiEOG6WHNMG.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    3.30.450.40. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01314. NorR.
    InterProiIPR003593. AAA+_ATPase.
    IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR009057. Homeodomain-like.
    IPR023944. NorR.
    IPR027417. P-loop_NTPase.
    IPR002078. Sigma_54_int.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR025943. Sigma_54_int_dom_ATP-bd_2.
    IPR025944. Sigma_54_int_dom_CS.
    [Graphical view]
    PfamiPF01590. GAF. 1 hit.
    PF00158. Sigma54_activat. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00065. GAF. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55781. SSF55781. 1 hit.
    PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
    PS00676. SIGMA54_INTERACT_2. 1 hit.
    PS00688. SIGMA54_INTERACT_3. 1 hit.
    PS50045. SIGMA54_INTERACT_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1AEP9-1 [UniParc]FASTAAdd to Basket

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    MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ    50
    FIPLAIDGLA KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG 100
    LIPGQESLKV HACVGLPLFA GQNLIGALTL DGMQPDQFDV FSDEELRLIA 150
    ALAAGALSNA LLIEQLESQN MLPGDAAPFE AVKQTQMIGL SPGMTQLKKE 200
    IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV YLNCAALPES 250
    VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL 300
    RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV 350
    FPLSVPPLRE RGDDVILLAG YFCEQCRLRL GLSRVVLSAG ARNLLQHYNF 400
    PGNVRELEHA IHRAVVLSRA TRSGDEVILE AQHFAFPEVT LPPPEAAAVP 450
    VVKQNLREAT EAFQRETIRQ ALAQNHHNWA ACARMLETDV ANLHRLAKRL 500
    GLKD 504
    Length:504
    Mass (Da):55,186
    Last modified:January 23, 2007 - v1
    Checksum:i7A0FEB53E863FE5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ02139.1.
    RefSeqiYP_853928.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ02139; ABJ02139; APECO1_3817.
    GeneIDi4494837.
    KEGGiecv:APECO1_3817.
    PATRICi18217543. VBIEscCol127180_3015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ02139.1 .
    RefSeqi YP_853928.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1AEP9.
    SMRi A1AEP9. Positions 185-432, 456-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_3817.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ02139 ; ABJ02139 ; APECO1_3817 .
    GeneIDi 4494837.
    KEGGi ecv:APECO1_3817.
    PATRICi 18217543. VBIEscCol127180_3015.

    Phylogenomic databases

    eggNOGi COG3604.
    HOGENOMi HOG000058487.
    KOi K12266.
    OMAi HSCIGLP.
    OrthoDBi EOG6WHNMG.

    Enzyme and pathway databases

    UniPathwayi UPA00638 .

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    3.30.450.40. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01314. NorR.
    InterProi IPR003593. AAA+_ATPase.
    IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR009057. Homeodomain-like.
    IPR023944. NorR.
    IPR027417. P-loop_NTPase.
    IPR002078. Sigma_54_int.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR025943. Sigma_54_int_dom_ATP-bd_2.
    IPR025944. Sigma_54_int_dom_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 1 hit.
    PF00158. Sigma54_activat. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00065. GAF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55781. SSF55781. 1 hit.
    PROSITEi PS00675. SIGMA54_INTERACT_1. 1 hit.
    PS00676. SIGMA54_INTERACT_2. 1 hit.
    PS00688. SIGMA54_INTERACT_3. 1 hit.
    PS50045. SIGMA54_INTERACT_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNORR_ECOK1
    AccessioniPrimary (citable) accession number: A1AEP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3