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A1AEP9

- NORR_ECOK1

UniProt

A1AEP9 - NORR_ECOK1

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Protein
Anaerobic nitric oxide reductase transcription regulator NorR
Gene
norR, Ecok1_26450, APECO1_3817
Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54 By similarity.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi215 – 2228ATP Reviewed prediction
Nucleotide bindingi278 – 28710ATP Reviewed prediction
DNA bindingi479 – 49820H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-KW
  3. nucleoside-triphosphatase activity Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphorelay signal transduction system Source: UniProtKB-HAMAP
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic nitric oxide reductase transcription regulator NorR
Gene namesi
Name:norR
Ordered Locus Names:Ecok1_26450
ORF Names:APECO1_3817
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Anaerobic nitric oxide reductase transcription regulator NorRUniRule annotation
PRO_0000305620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 5714-aspartylphosphate By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi405955.APECO1_3817.

Structurei

3D structure databases

ProteinModelPortaliA1AEP9.
SMRiA1AEP9. Positions 185-432, 456-503.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 416230Sigma-54 factor interaction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3604.
HOGENOMiHOG000058487.
KOiK12266.
OMAiHSCIGLP.
OrthoDBiEOG6WHNMG.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01314. NorR.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR009057. Homeodomain-like.
IPR023944. NorR.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AEP9-1 [UniParc]FASTAAdd to Basket

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MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ    50
FIPLAIDGLA KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG 100
LIPGQESLKV HACVGLPLFA GQNLIGALTL DGMQPDQFDV FSDEELRLIA 150
ALAAGALSNA LLIEQLESQN MLPGDAAPFE AVKQTQMIGL SPGMTQLKKE 200
IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV YLNCAALPES 250
VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL 300
RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV 350
FPLSVPPLRE RGDDVILLAG YFCEQCRLRL GLSRVVLSAG ARNLLQHYNF 400
PGNVRELEHA IHRAVVLSRA TRSGDEVILE AQHFAFPEVT LPPPEAAAVP 450
VVKQNLREAT EAFQRETIRQ ALAQNHHNWA ACARMLETDV ANLHRLAKRL 500
GLKD 504
Length:504
Mass (Da):55,186
Last modified:January 23, 2007 - v1
Checksum:i7A0FEB53E863FE5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ02139.1.
RefSeqiYP_853928.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ02139; ABJ02139; APECO1_3817.
GeneIDi4494837.
KEGGiecv:APECO1_3817.
PATRICi18217543. VBIEscCol127180_3015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ02139.1 .
RefSeqi YP_853928.1. NC_008563.1.

3D structure databases

ProteinModelPortali A1AEP9.
SMRi A1AEP9. Positions 185-432, 456-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_3817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ02139 ; ABJ02139 ; APECO1_3817 .
GeneIDi 4494837.
KEGGi ecv:APECO1_3817.
PATRICi 18217543. VBIEscCol127180_3015.

Phylogenomic databases

eggNOGi COG3604.
HOGENOMi HOG000058487.
KOi K12266.
OMAi HSCIGLP.
OrthoDBi EOG6WHNMG.

Enzyme and pathway databases

UniPathwayi UPA00638 .

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01314. NorR.
InterProi IPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR009057. Homeodomain-like.
IPR023944. NorR.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view ]
Pfami PF01590. GAF. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEi PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNORR_ECOK1
AccessioniPrimary (citable) accession number: A1AEP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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