A1AEP9 (NORR_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anaerobic nitric oxide reductase transcription regulator NorR

Gene names

Name:	norR
Ordered Locus Names:	Ecok1_26450
ORF Names:	APECO1_3817

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54 By similarity. HAMAP-Rule MF_01314
Pathway	Nitrogen metabolism; nitric oxide reduction. HAMAP-Rule MF_01314
Sequence similarities	Contains 1 sigma-54 factor interaction domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	ATP-binding DNA-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phosphorelay signal transduction system Inferred from electronic annotation. Source: HAMAP sensory perception Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Anaerobic nitric oxide reductase transcription regulator NorR HAMAP-Rule MF_01314		PRO_0000305620
Regions
	Domain	187 – 416	230	Sigma-54 factor interaction
	Nucleotide binding	215 – 222	8	ATP Potential
	Nucleotide binding	278 – 287	10	ATP Potential
	DNA binding	479 – 498	20	H-T-H motif By similarity
Amino acid modifications
	Modified residue	57	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1AEP9 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 7A0FEB53E863FE5A	FASTA	504	55,186
	10 20 30 40 50 60 MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ FIPLAIDGLA 70 80 90 100 110 120 KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG LIPGQESLKV HACVGLPLFA 130 140 150 160 170 180 GQNLIGALTL DGMQPDQFDV FSDEELRLIA ALAAGALSNA LLIEQLESQN MLPGDAAPFE 190 200 210 220 230 240 AVKQTQMIGL SPGMTQLKKE IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV 250 260 270 280 290 300 YLNCAALPES VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL 310 320 330 340 350 360 RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV FPLSVPPLRE 370 380 390 400 410 420 RGDDVILLAG YFCEQCRLRL GLSRVVLSAG ARNLLQHYNF PGNVRELEHA IHRAVVLSRA 430 440 450 460 470 480 TRSGDEVILE AQHFAFPEVT LPPPEAAAVP VVKQNLREAT EAFQRETIRQ ALAQNHHNWA 490 500 ACARMLETDV ANLHRLAKRL GLKD

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABJ02139.1.
RefSeq	YP_853928.1. NC_008563.1.
3D structure databases
ProteinModelPortal	A1AEP9.
SMR	A1AEP9. Positions 185-432, 456-503.
ModBase	Search...
Protein-protein interaction databases
STRING	405955.APECO1_3817.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ02139; ABJ02139; APECO1_3817.
GeneID	4494837.
KEGG	ecv:APECO1_3817.
PATRIC	18217543. VBIEscCol127180_3015.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3604.
HOGENOM	HOG000058487.
KO	K12266.
OMA	DSEAKMS.
ProtClustDB	PRK05022.
Enzyme and pathway databases
UniPathway	UPA00638.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
HAMAP	MF_01314. NorR.
InterPro	IPR003593. AAA+_ATPase. IPR003018. GAF. IPR009057. Homeodomain-like. IPR023944. NorR. IPR002078. Sigma_54_int. IPR025662. Sigma_54_int_dom_ATP-bd_1. IPR025943. Sigma_54_int_dom_ATP-bd_2. IPR025944. Sigma_54_int_dom_CS. [Graphical view]
Pfam	PF01590. GAF. 1 hit. PF00158. Sigma54_activat. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00065. GAF. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00675. SIGMA54_INTERACT_1. 1 hit. PS00676. SIGMA54_INTERACT_2. 1 hit. PS00688. SIGMA54_INTERACT_3. 1 hit. PS50045. SIGMA54_INTERACT_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NORR_ECOK1

Accession

Primary (citable) accession number: A1AEP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program