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Protein

Anaerobic nitric oxide reductase transcription regulator NorR

Gene

norR

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi215 – 2228ATPUniRule annotation
Nucleotide bindingi278 – 28710ATPUniRule annotation
DNA bindingi479 – 49820H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphorelay signal transduction system Source: UniProtKB-HAMAP
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic nitric oxide reductase transcription regulator NorRUniRule annotation
Gene namesi
Name:norRUniRule annotation
Ordered Locus Names:Ecok1_26450
ORF Names:APECO1_3817
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Anaerobic nitric oxide reductase transcription regulator NorRPRO_0000305620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 5714-aspartylphosphateUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi405955.APECO1_3817.

Structurei

3D structure databases

ProteinModelPortaliA1AEP9.
SMRiA1AEP9. Positions 185-432, 456-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 416230Sigma-54 factor interactionUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 sigma-54 factor interaction domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG3604.
HOGENOMiHOG000058487.
KOiK12266.
OMAiVHSCIGL.
OrthoDBiEOG6WHNMG.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01314. NorR.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR009057. Homeodomain-like.
IPR023944. NorR.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AEP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ
60 70 80 90 100
FIPLAIDGLA KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG
110 120 130 140 150
LIPGQESLKV HACVGLPLFA GQNLIGALTL DGMQPDQFDV FSDEELRLIA
160 170 180 190 200
ALAAGALSNA LLIEQLESQN MLPGDAAPFE AVKQTQMIGL SPGMTQLKKE
210 220 230 240 250
IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV YLNCAALPES
260 270 280 290 300
VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL
310 320 330 340 350
RVLQYGDIQR VGDDRSLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV
360 370 380 390 400
FPLSVPPLRE RGDDVILLAG YFCEQCRLRL GLSRVVLSAG ARNLLQHYNF
410 420 430 440 450
PGNVRELEHA IHRAVVLSRA TRSGDEVILE AQHFAFPEVT LPPPEAAAVP
460 470 480 490 500
VVKQNLREAT EAFQRETIRQ ALAQNHHNWA ACARMLETDV ANLHRLAKRL

GLKD
Length:504
Mass (Da):55,186
Last modified:January 23, 2007 - v1
Checksum:i7A0FEB53E863FE5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ02139.1.
RefSeqiYP_853928.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ02139; ABJ02139; APECO1_3817.
KEGGiecv:APECO1_3817.
PATRICi18217543. VBIEscCol127180_3015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ02139.1.
RefSeqiYP_853928.1. NC_008563.1.

3D structure databases

ProteinModelPortaliA1AEP9.
SMRiA1AEP9. Positions 185-432, 456-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405955.APECO1_3817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ02139; ABJ02139; APECO1_3817.
KEGGiecv:APECO1_3817.
PATRICi18217543. VBIEscCol127180_3015.

Phylogenomic databases

eggNOGiCOG3604.
HOGENOMiHOG000058487.
KOiK12266.
OMAiVHSCIGL.
OrthoDBiEOG6WHNMG.

Enzyme and pathway databases

UniPathwayiUPA00638.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01314. NorR.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR009057. Homeodomain-like.
IPR023944. NorR.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNORR_ECOK1
AccessioniPrimary (citable) accession number: A1AEP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.