Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronUniRule annotation1
Metal bindingi58IronUniRule annotation1
Metal bindingi128IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • quorum sensing Source: CACAO
  • regulation of cell motility Source: CACAO

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:Ecok1_26280
ORF Names:APECO1_3834
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008216 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979961 – 171S-ribosylhomocysteine lyaseAdd BLAST171

Proteomic databases

PRIDEiA1AEN2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1AEN2.
SMRiA1AEN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040371.
KOiK07173.
OMAiAIHTLEH.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS. 1 hit.
InterProiView protein in InterPro
IPR037005. LuxS_sf.
IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
PfamiView protein in Pfam
PF02664. LuxS. 1 hit.
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172. S-ribosylhomocysteinase. 1 hit.
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AEN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLDSFTVD HTRMEAPAVR VAKTMNTPHG DAITVFDLRF CVPNKEVMPE
60 70 80 90 100
RGIHTLEHLF AGFMRNHLNG NGVEIIDISP MGCRTGFYMS LIGTPDEQRV
110 120 130 140 150
ADAWKAAMED VLKVQDQNQI PELNVYQCGT YQMHSLQEAQ DIARSILERD
160 170
VRINSNEELA LPKEKLQELH I
Length:171
Mass (Da):19,416
Last modified:January 23, 2007 - v1
Checksum:i131F57F1866DA105
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ02122.1.
RefSeqiWP_001130211.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ02122; ABJ02122; APECO1_3834.
KEGGiecv:APECO1_3834.

Similar proteinsi

Entry informationi

Entry nameiLUXS_ECOK1
AccessioniPrimary (citable) accession number: A1AEN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families