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A1ADR5 (YFEO_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative ion-transport protein YfeO
Gene names
Name:yfeO
Ordered Locus Names:Ecok1_23110
ORF Names:APECO1_4148
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01115.

Sequence similarities

Belongs to the chloride channel (TC 2.A.49) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionIon channel
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionvoltage-gated chloride channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Putative ion-transport protein YfeO HAMAP-Rule MF_01115
PRO_0000298431

Regions

Transmembrane10 – 3021Helical; Potential
Transmembrane54 – 7421Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane322 – 34221Helical; Potential
Transmembrane343 – 36321Helical; Potential
Transmembrane371 – 39121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1ADR5 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 15E748AB039F2B2C

FASTA41843,664
        10         20         30         40         50         60 
MLHPRARTML LLSLPAVAIG IASSLILIMV MKIASVLQNL LWQRLPGTLG IAQDSPLWII 

        70         80         90        100        110        120 
GVLTLTGIAV GLVIRFSQGH AGPDPACEPL IGAPVPPSAL PGLIVALILG LAGGVSLGPE 

       130        140        150        160        170        180 
HPIMTVNIAL AVAIGARLLP RVNRMEWTIL ASAGTIGALF GTPVAAALIF SQTLNGSNEV 

       190        200        210        220        230        240 
PLWDRLFAPL MAAAAGALTT GLFFHPHFSL PIAHYGQMEM TDILSGAIVA AIAIAAGMVA 

       250        260        270        280        290        300 
VWCLPRLHAM MHQMKNPVFV LGIGGLILGI LGVIGGPVSL FKGLDEMQQM VANQAFSTSD 

       310        320        330        340        350        360 
YFLLAVIKLA ALVVAAASGF RGGRIFPAVF VGVALGLMLH EHVPAVPAAI TVSCAILGIV 

       370        380        390        400        410 
LVVTRDGWLS LFMAAVVVPN TTLLPLLCIV MLPAWLLLAG KPMMMVNRQK QQPPHDNV

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000468 Genomic DNA. Translation: ABJ01805.1.
RefSeqYP_853519.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1ADR5.
ModBaseSearch...

Protein-protein interaction databases

STRING405955.APECO1_4148.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ01805; ABJ01805; APECO1_4148.
GeneID4491678.
KEGGecv:APECO1_4148.
PATRIC18216775. VBIEscCol127180_2648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0038.
HOGENOMHOG000267985.
OMACGFRGGR.
ProtClustDBPRK03655.

Family and domain databases

Gene3D1.10.3080.10. 1 hit.
HAMAPMF_01115. CLC_YfeO.
InterProIPR022969. Chloride_channel_YfeO.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
[Graphical view]
PfamPF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSPR00762. CLCHANNEL.
SUPFAMSSF81340. Cl-channel_core. 1 hit.
ProtoNetSearch...

Entry information

Entry nameYFEO_ECOK1
AccessionPrimary (citable) accession number: A1ADR5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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