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A1ADR4

- GLK_ECOK1

UniProt

A1ADR4 - GLK_ECOK1

Protein

Glucokinase

Gene

glk

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 136ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glucokinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlucokinaseUniRule annotation (EC:2.7.1.2UniRule annotation)
    Alternative name(s):
    Glucose kinaseUniRule annotation
    Gene namesi
    Name:glkUniRule annotation
    Ordered Locus Names:Ecok1_23100
    ORF Names:APECO1_4149
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321GlucokinasePRO_1000050967Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405955.APECO1_4149.

    Structurei

    3D structure databases

    ProteinModelPortaliA1ADR4.
    SMRiA1ADR4. Positions 2-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bacterial glucokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0837.
    HOGENOMiHOG000274469.
    KOiK00845.
    OMAiPRETQLW.
    OrthoDBiEOG64BQ47.

    Family and domain databases

    HAMAPiMF_00524. Glucokinase.
    InterProiIPR003836. Glucokinase.
    [Graphical view]
    PfamiPF02685. Glucokinase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00749. glk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1ADR4-1 [UniParc]FASTAAdd to Basket

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    MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE    50
    EHKVEVKDGC IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND 100
    FTAVSMAIPM LKKEHLIQFG GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR 150
    WVSLPGEGGH VDFAPNSEEE GIILEILRAE IGHVSAERVL SGPGLVNLYR 200
    AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI MGRFGGNLAL 250
    NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV 300
    HDNPGLLGSG AHLRQTLGHI L 321
    Length:321
    Mass (Da):34,709
    Last modified:January 23, 2007 - v1
    Checksum:i42ACBF56627A5C98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ01804.1.
    RefSeqiYP_853518.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ01804; ABJ01804; APECO1_4149.
    GeneIDi4491677.
    KEGGiecv:APECO1_4149.
    PATRICi18216773. VBIEscCol127180_2647.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ01804.1 .
    RefSeqi YP_853518.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1ADR4.
    SMRi A1ADR4. Positions 2-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_4149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ01804 ; ABJ01804 ; APECO1_4149 .
    GeneIDi 4491677.
    KEGGi ecv:APECO1_4149.
    PATRICi 18216773. VBIEscCol127180_2647.

    Phylogenomic databases

    eggNOGi COG0837.
    HOGENOMi HOG000274469.
    KOi K00845.
    OMAi PRETQLW.
    OrthoDBi EOG64BQ47.

    Family and domain databases

    HAMAPi MF_00524. Glucokinase.
    InterProi IPR003836. Glucokinase.
    [Graphical view ]
    Pfami PF02685. Glucokinase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00749. glk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGLK_ECOK1
    AccessioniPrimary (citable) accession number: A1ADR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3