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A1ADC4

- NUON_ECOK1

UniProt

A1ADC4 - NUON_ECOK1

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:Ecok1_21700
ORF Names:APECO1_4289
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485NADH-quinone oxidoreductase subunit NPRO_1000017376Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi405955.APECO1_4289.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalUniRule annotationAdd
BLAST
Transmembranei35 – 5521HelicalUniRule annotationAdd
BLAST
Transmembranei71 – 9121HelicalUniRule annotationAdd
BLAST
Transmembranei105 – 12521HelicalUniRule annotationAdd
BLAST
Transmembranei127 – 14721HelicalUniRule annotationAdd
BLAST
Transmembranei159 – 17921HelicalUniRule annotationAdd
BLAST
Transmembranei203 – 22321HelicalUniRule annotationAdd
BLAST
Transmembranei235 – 25521HelicalUniRule annotationAdd
BLAST
Transmembranei271 – 29121HelicalUniRule annotationAdd
BLAST
Transmembranei297 – 31721HelicalUniRule annotationAdd
BLAST
Transmembranei326 – 34621HelicalUniRule annotationAdd
BLAST
Transmembranei373 – 39321HelicalUniRule annotationAdd
BLAST
Transmembranei408 – 43023HelicalUniRule annotationAdd
BLAST
Transmembranei455 – 47521HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100796.
KOiK00343.
OMAiSIVQLAM.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1ADC4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTITPQNLIA LLPLLIVGLT VVVVMLSIAW RRNHFLNATL SVIGLNAALV
60 70 80 90 100
SLWFVGQAGA MDVTPLMRVD GFAMLYTGLV LLASLATCTF AYPWLEGYND
110 120 130 140 150
NKDEFYLLVL IAALGGILLA NANHLASLFL GIELISLPLF GLVGYAFRQK
160 170 180 190 200
RSLEASIKYT ILSAAASSFL LFGMALVYAQ SGDLSFVALG KNLGDGMLNE
210 220 230 240 250
PLLLAGFGLM IVGLGFKLSL VPFHLWTPDV YQGAPAPVST FLATASKIAI
260 270 280 290 300
FGVVMRLFLY APVGDSEAIR VVLAIIAFAS IIFGNLMALS QTNIKRLLGY
310 320 330 340 350
SSISHLGYLL VALIALQTGE MSMEAVGVYL VGYLFSSLGA FGVVSLMSSP
360 370 380 390 400
YRGPDADSLF SYRGLFWHRP ILAAVMTVMM LSLAGIPMTL GFIGKFYVLA
410 420 430 440 450
VGVQAHLWWL VGAVVVGSAI GLYYYLRVAV SLYLHAPEQP GRDAPSNWQY
460 470 480
SAGGIVVLIS ALLVLVLGVW PQPLISIVRL AMPLM
Length:485
Mass (Da):52,072
Last modified:January 23, 2007 - v1
Checksum:iBFBFAEF428B0FA09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ01664.1.
RefSeqiYP_853378.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ01664; ABJ01664; APECO1_4289.
GeneIDi4492519.
KEGGiecv:APECO1_4289.
PATRICi18216473. VBIEscCol127180_2498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ01664.1 .
RefSeqi YP_853378.1. NC_008563.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_4289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ01664 ; ABJ01664 ; APECO1_4289 .
GeneIDi 4492519.
KEGGi ecv:APECO1_4289.
PATRICi 18216473. VBIEscCol127180_2498.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100796.
KOi K00343.
OMAi SIVQLAM.
OrthoDBi EOG64JFNZ.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNUON_ECOK1
AccessioniPrimary (citable) accession number: A1ADC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3