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A1ACB6 (YEDY_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfoxide reductase catalytic subunit YedY

EC=1.8.-.-
Gene names
Name:yedY
Ordered Locus Names:Ecok1_18120
ORF Names:APECO1_1006
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase By similarity. HAMAP-Rule MF_01206

Cofactor

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Subunit structure

Heterodimer of a catalytic subunit (YedY) and a heme-binding subunit (YedZ) By similarity.

Subcellular location

Periplasm By similarity. Note: Is attached to the inner membrane when interacting with the YedZ subunit By similarity. HAMAP-Rule MF_01206

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. HAMAP-Rule MF_01206

Sequence similarities

Belongs to the YedY family.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainSignal
   LigandMetal-binding
Molybdenum
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

molybdopterin cofactor binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

oxidoreductase activity, acting on a sulfur group of donors

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4444Tat-type signal Potential
Chain45 – 334290Sulfoxide reductase catalytic subunit YedY HAMAP-Rule MF_01206
PRO_1000066157

Regions

Region91 – 922Molybdopterin binding By similarity
Region249 – 2513Molybdopterin binding By similarity

Sites

Metal binding1461Molybdenum By similarity
Binding site881Molybdopterin By similarity
Binding site1811Molybdopterin By similarity
Binding site2331Molybdopterin By similarity
Binding site2381Molybdopterin By similarity

Sequences

Sequence LengthMass (Da)Tools
A1ACB6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: A6A0FF0A2E349006

FASTA33437,370
        10         20         30         40         50         60 
MKKNQFLKES DVTAESVFFM KRRQVLKALG ISAAALSLPH AAHADLLSWF KGNDRPPAPA 

        70         80         90        100        110        120 
GKALEFSKPA AWQNNLPLTP ADKVSGYNNF YEFGLDKADP AANAGSLKTD PWTLKISGEV 

       130        140        150        160        170        180 
AKPLTLDHDD LTRRFPLEER IYRMRCVEAW SMVVPWIGFP LHKLLALAEP TSNAKYVAFE 

       190        200        210        220        230        240 
TIYAPEQMPG QQDRFIGGGL KYPYVEGLRL DEAMHPLTLM TVGVYGKALP PQNGAPVRLI 

       250        260        270        280        290        300 
VPWKYGFKGI KSIVSIKLTR ERPPTTWNLA APDEYGFYAN VNPHVDHPRW SQATERFIGS 

       310        320        330 
GGILNVQRQP TLLFNGYAEQ VASLYRGLDL RENF 

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABJ01306.1.
RefSeqYP_853020.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1ACB6.
SMRA1ACB6. Positions 62-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_1006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ01306; ABJ01306; APECO1_1006.
GeneID4492650.
KEGGecv:APECO1_1006.
PATRIC18215585. VBIEscCol127180_2065.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2041.
HOGENOMHOG000255004.
KOK07147.
OMAITPFKDA.
OrthoDBEOG6FBWVX.

Family and domain databases

Gene3D3.90.420.10. 1 hit.
HAMAPMF_01206. YedY.
InterProIPR000572. OxRdtase_Mopterin-bd_dom.
IPR006311. TAT_signal.
IPR022867. YedY.
[Graphical view]
PfamPF00174. Oxidored_molyb. 1 hit.
[Graphical view]
SUPFAMSSF56524. SSF56524. 1 hit.
PROSITEPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYEDY_ECOK1
AccessionPrimary (citable) accession number: A1ACB6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families