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A1ACB6

- YEDY_ECOK1

UniProt

A1ACB6 - YEDY_ECOK1

Protein

Sulfoxide reductase catalytic subunit YedY

Gene

yedY

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase.UniRule annotation

    Cofactori

    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881MolybdopterinUniRule annotation
    Metal bindingi146 – 1461MolybdenumUniRule annotation
    Binding sitei181 – 1811MolybdopterinUniRule annotation
    Binding sitei233 – 2331MolybdopterinUniRule annotation
    Binding sitei238 – 2381MolybdopterinUniRule annotation

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. molybdopterin cofactor binding Source: UniProtKB-HAMAP
    4. oxidoreductase activity, acting on a sulfur group of donors Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, Molybdenum

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfoxide reductase catalytic subunit YedYUniRule annotation (EC:1.8.-.-UniRule annotation)
    Gene namesi
    Name:yedYUniRule annotation
    Ordered Locus Names:Ecok1_18120
    ORF Names:APECO1_1006
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Periplasm UniRule annotation
    Note: Is attached to the inner membrane when interacting with the YedZ subunit.UniRule annotation

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4444Tat-type signalUniRule annotationAdd
    BLAST
    Chaini45 – 334290Sulfoxide reductase catalytic subunit YedYPRO_1000066157Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Interactioni

    Subunit structurei

    Heterodimer of a catalytic subunit (YedY) and a heme-binding subunit (YedZ).UniRule annotation

    Protein-protein interaction databases

    STRINGi405955.APECO1_1006.

    Structurei

    3D structure databases

    ProteinModelPortaliA1ACB6.
    SMRiA1ACB6. Positions 62-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni91 – 922Molybdopterin bindingUniRule annotation
    Regioni249 – 2513Molybdopterin bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the YedY family.UniRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2041.
    HOGENOMiHOG000255004.
    KOiK07147.
    OMAiITPFKDA.
    OrthoDBiEOG6FBWVX.

    Family and domain databases

    Gene3Di3.90.420.10. 1 hit.
    HAMAPiMF_01206. YedY.
    InterProiIPR000572. OxRdtase_Mopterin-bd_dom.
    IPR006311. TAT_signal.
    IPR022867. YedY.
    [Graphical view]
    PfamiPF00174. Oxidored_molyb. 1 hit.
    [Graphical view]
    SUPFAMiSSF56524. SSF56524. 1 hit.
    PROSITEiPS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1ACB6-1 [UniParc]FASTAAdd to Basket

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    MKKNQFLKES DVTAESVFFM KRRQVLKALG ISAAALSLPH AAHADLLSWF    50
    KGNDRPPAPA GKALEFSKPA AWQNNLPLTP ADKVSGYNNF YEFGLDKADP 100
    AANAGSLKTD PWTLKISGEV AKPLTLDHDD LTRRFPLEER IYRMRCVEAW 150
    SMVVPWIGFP LHKLLALAEP TSNAKYVAFE TIYAPEQMPG QQDRFIGGGL 200
    KYPYVEGLRL DEAMHPLTLM TVGVYGKALP PQNGAPVRLI VPWKYGFKGI 250
    KSIVSIKLTR ERPPTTWNLA APDEYGFYAN VNPHVDHPRW SQATERFIGS 300
    GGILNVQRQP TLLFNGYAEQ VASLYRGLDL RENF 334
    Length:334
    Mass (Da):37,370
    Last modified:January 23, 2007 - v1
    Checksum:iA6A0FF0A2E349006
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ01306.1.
    RefSeqiYP_853020.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ01306; ABJ01306; APECO1_1006.
    GeneIDi4492650.
    KEGGiecv:APECO1_1006.
    PATRICi18215585. VBIEscCol127180_2065.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ01306.1 .
    RefSeqi YP_853020.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1ACB6.
    SMRi A1ACB6. Positions 62-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_1006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ01306 ; ABJ01306 ; APECO1_1006 .
    GeneIDi 4492650.
    KEGGi ecv:APECO1_1006.
    PATRICi 18215585. VBIEscCol127180_2065.

    Phylogenomic databases

    eggNOGi COG2041.
    HOGENOMi HOG000255004.
    KOi K07147.
    OMAi ITPFKDA.
    OrthoDBi EOG6FBWVX.

    Family and domain databases

    Gene3Di 3.90.420.10. 1 hit.
    HAMAPi MF_01206. YedY.
    InterProi IPR000572. OxRdtase_Mopterin-bd_dom.
    IPR006311. TAT_signal.
    IPR022867. YedY.
    [Graphical view ]
    Pfami PF00174. Oxidored_molyb. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56524. SSF56524. 1 hit.
    PROSITEi PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiYEDY_ECOK1
    AccessioniPrimary (citable) accession number: A1ACB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3