A1ACB6 (YEDY_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfoxide reductase catalytic subunit YedY
EC=1.8.-.-

Gene names

Name:	yedY
Ordered Locus Names:	Ecok1_18120
ORF Names:	APECO1_1006

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase By similarity. HAMAP-Rule MF_01206
Cofactor	Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.
Subunit structure	Heterodimer of a catalytic subunit (YedY) and a heme-binding subunit (YedZ) By similarity.
Subcellular location	Periplasm By similarity. Note: Is attached to the inner membrane when interacting with the YedZ subunit By similarity.
Post-translational modification	Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. HAMAP-Rule MF_01206
Sequence similarities	Belongs to the YedY family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Ligand	Metal-binding Molybdenum
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW molybdopterin cofactor binding Inferred from electronic annotation. Source: HAMAP oxidoreductase activity, acting on a sulfur group of donors Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 44	44	Tat-type signal Potential
	Chain	45 – 334	290	Sulfoxide reductase catalytic subunit YedY HAMAP-Rule MF_01206		PRO_1000066157
Regions
	Region	91 – 92	2	Molybdopterin binding By similarity
	Region	249 – 251	3	Molybdopterin binding By similarity
Sites
	Metal binding	146	1	Molybdenum By similarity
	Binding site	88	1	Molybdopterin By similarity
	Binding site	181	1	Molybdopterin By similarity
	Binding site	233	1	Molybdopterin By similarity
	Binding site	238	1	Molybdopterin By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1ACB6 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: A6A0FF0A2E349006	FASTA	334	37,370
	10 20 30 40 50 60 MKKNQFLKES DVTAESVFFM KRRQVLKALG ISAAALSLPH AAHADLLSWF KGNDRPPAPA 70 80 90 100 110 120 GKALEFSKPA AWQNNLPLTP ADKVSGYNNF YEFGLDKADP AANAGSLKTD PWTLKISGEV 130 140 150 160 170 180 AKPLTLDHDD LTRRFPLEER IYRMRCVEAW SMVVPWIGFP LHKLLALAEP TSNAKYVAFE 190 200 210 220 230 240 TIYAPEQMPG QQDRFIGGGL KYPYVEGLRL DEAMHPLTLM TVGVYGKALP PQNGAPVRLI 250 260 270 280 290 300 VPWKYGFKGI KSIVSIKLTR ERPPTTWNLA APDEYGFYAN VNPHVDHPRW SQATERFIGS 310 320 330 GGILNVQRQP TLLFNGYAEQ VASLYRGLDL RENF

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABJ01306.1.
RefSeq	YP_853020.1. NC_008563.1.
3D structure databases
ProteinModelPortal	A1ACB6.
SMR	A1ACB6. Positions 62-330.
ModBase	Search...
Protein-protein interaction databases
STRING	405955.APECO1_1006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ01306; ABJ01306; APECO1_1006.
GeneID	4492650.
KEGG	ecv:APECO1_1006.
PATRIC	18215585. VBIEscCol127180_2065.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2041.
HOGENOM	HOG000255004.
KO	K07147.
OMA	TQMFNGY.
ProtClustDB	PRK05363.
Family and domain databases
Gene3D	3.90.420.10. 1 hit.
HAMAP	MF_01206. YedY.
InterPro	IPR000572. OxRdtase_Mopterin-bd_dom. IPR006311. TAT_signal. IPR022867. YedY. [Graphical view]
Pfam	PF00174. Oxidored_molyb. 1 hit. [Graphical view]
SUPFAM	SSF56524. Oxidored_molyb. 1 hit.
PROSITE	PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YEDY_ECOK1

Accession

Primary (citable) accession number: A1ACB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program