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A1ACB6

- YEDY_ECOK1

UniProt

A1ACB6 - YEDY_ECOK1

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Protein

Sulfoxide reductase catalytic subunit YedY

Gene

yedY

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase.UniRule annotation

Cofactori

Mo-molybdopterinUniRule annotationNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881MolybdopterinUniRule annotation
Metal bindingi146 – 1461MolybdenumUniRule annotation
Binding sitei181 – 1811MolybdopterinUniRule annotation
Binding sitei233 – 2331MolybdopterinUniRule annotation
Binding sitei238 – 2381MolybdopterinUniRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. molybdopterin cofactor binding Source: UniProtKB-HAMAP
  4. oxidoreductase activity, acting on a sulfur group of donors Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Molybdenum

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfoxide reductase catalytic subunit YedYUniRule annotation (EC:1.8.-.-UniRule annotation)
Gene namesi
Name:yedYUniRule annotation
Ordered Locus Names:Ecok1_18120
ORF Names:APECO1_1006
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Periplasm UniRule annotation
Note: Is attached to the inner membrane when interacting with the YedZ subunit.UniRule annotation

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Tat-type signalUniRule annotationAdd
BLAST
Chaini45 – 334290Sulfoxide reductase catalytic subunit YedYPRO_1000066157Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit (YedY) and a heme-binding subunit (YedZ).UniRule annotation

Protein-protein interaction databases

STRINGi405955.APECO1_1006.

Structurei

3D structure databases

ProteinModelPortaliA1ACB6.
SMRiA1ACB6. Positions 62-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 922Molybdopterin bindingUniRule annotation
Regioni249 – 2513Molybdopterin bindingUniRule annotation

Sequence similaritiesi

Belongs to the YedY family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2041.
HOGENOMiHOG000255004.
KOiK07147.
OMAiITPFKDA.
OrthoDBiEOG6FBWVX.

Family and domain databases

Gene3Di3.90.420.10. 1 hit.
HAMAPiMF_01206. YedY.
InterProiIPR000572. OxRdtase_Mopterin-bd_dom.
IPR006311. TAT_signal.
IPR022867. YedY.
[Graphical view]
PfamiPF00174. Oxidored_molyb. 1 hit.
[Graphical view]
SUPFAMiSSF56524. SSF56524. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1ACB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKNQFLKES DVTAESVFFM KRRQVLKALG ISAAALSLPH AAHADLLSWF
60 70 80 90 100
KGNDRPPAPA GKALEFSKPA AWQNNLPLTP ADKVSGYNNF YEFGLDKADP
110 120 130 140 150
AANAGSLKTD PWTLKISGEV AKPLTLDHDD LTRRFPLEER IYRMRCVEAW
160 170 180 190 200
SMVVPWIGFP LHKLLALAEP TSNAKYVAFE TIYAPEQMPG QQDRFIGGGL
210 220 230 240 250
KYPYVEGLRL DEAMHPLTLM TVGVYGKALP PQNGAPVRLI VPWKYGFKGI
260 270 280 290 300
KSIVSIKLTR ERPPTTWNLA APDEYGFYAN VNPHVDHPRW SQATERFIGS
310 320 330
GGILNVQRQP TLLFNGYAEQ VASLYRGLDL RENF
Length:334
Mass (Da):37,370
Last modified:January 23, 2007 - v1
Checksum:iA6A0FF0A2E349006
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ01306.1.
RefSeqiYP_853020.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ01306; ABJ01306; APECO1_1006.
GeneIDi4492650.
KEGGiecv:APECO1_1006.
PATRICi18215585. VBIEscCol127180_2065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ01306.1 .
RefSeqi YP_853020.1. NC_008563.1.

3D structure databases

ProteinModelPortali A1ACB6.
SMRi A1ACB6. Positions 62-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_1006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ01306 ; ABJ01306 ; APECO1_1006 .
GeneIDi 4492650.
KEGGi ecv:APECO1_1006.
PATRICi 18215585. VBIEscCol127180_2065.

Phylogenomic databases

eggNOGi COG2041.
HOGENOMi HOG000255004.
KOi K07147.
OMAi ITPFKDA.
OrthoDBi EOG6FBWVX.

Family and domain databases

Gene3Di 3.90.420.10. 1 hit.
HAMAPi MF_01206. YedY.
InterProi IPR000572. OxRdtase_Mopterin-bd_dom.
IPR006311. TAT_signal.
IPR022867. YedY.
[Graphical view ]
Pfami PF00174. Oxidored_molyb. 1 hit.
[Graphical view ]
SUPFAMi SSF56524. SSF56524. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiYEDY_ECOK1
AccessioniPrimary (citable) accession number: A1ACB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3