A1ABS7 (A1ABS7_ECOK1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Succinylglutamic semialdehyde dehydrogenase EMBL ABJ01117.1

Gene names

Name:	thrL EMBL ABJ01117.1
Ordered Locus Names:	Ecok1_16230
ORF Names:	APECO1_815 EMBL ABJ01117.1

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. SAAS SAAS017649
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. SAAS SAAS017649
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. SAAS SAAS017649
Sequence similarities	Belongs to the aldehyde dehydrogenase family. RuleBase RU003345

Ontologies

Keywords
Biological process	Arginine metabolism SAAS SAAS017649
Ligand	NAD SAAS SAAS017649
Molecular function	Oxidoreductase RuleBase RU003344 SAAS SAAS017649
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1ABS7 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 3B32E3CE889E5BA7	FASTA	395	42,426
	10 20 30 40 50 60 MTAMINKIAI SIKAYHVRTG EQRSEMPDGA ASLRHRPHGV LAVFGPYNFP GHLPNGHIVP 70 80 90 100 110 120 ALLAGNTIIF KPSELTPWSG DAVMRLWQQA GLPPGVLNLV QGGRETGQAL SALEDLDGLL 130 140 150 160 170 180 FTGSANTGYQ LHRQLSGQPE KILALEMGGN NPLIIDEVAD IDAAVHLTIQ SAFVTAGQRC 190 200 210 220 230 240 TCARRLFLKS GTQGDAFLAR LVAVSQRLTP GTWDDEPQPF IGGLISEQAA QQVVTAWQEL 250 260 270 280 290 300 EAMGGRTLLA PRLLQAGTSL LTPGIIEMTG VTGLPDEEVF GPLLRVWRYD NFDEAIRMAN 310 320 330 340 350 360 NTRFGLSCGL VSPEREKFDQ LLLEARAGIV NWNKPLTGAA STAPFGGIGA SGNHRPSAWY 370 380 390 AADYCAWPMA SLESDSLTLP ATLNPGLDFS DEVVR

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed: 17293413] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABJ01117.1.
RefSeq	YP_852831.1. NC_008563.1.
3D structure databases
ProteinModelPortal	A1ABS7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1ABS7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000038553; EBESCP00000037070; EBESCG00000037603.
GeneID	4495254.
GenomeReviews	Gene locus Ecok1_16230 in contig CP000468_GR.
KEGG	ecv:APECO1_815.
PATRIC	18215118. VBIEscCol127180_1835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
GeneTree	EBGT00050000009176.
HOGENOM	HBG752218.
OMA	KAYHART.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K06447.
PANTHER	PTHR11699:SF24. PTHR11699:SF24. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR03240. Arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1ABS7_ECOK1

Accession

Primary (citable) accession number: A1ABS7

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)