ID MDTK_ECOK1 Reviewed; 457 AA. AC A1ABK4; DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 1. DT 27-MAR-2024, entry version 86. DE RecName: Full=Multidrug resistance protein MdtK {ECO:0000255|HAMAP-Rule:MF_00400}; DE AltName: Full=Multidrug-efflux transporter {ECO:0000255|HAMAP-Rule:MF_00400}; GN Name=mdtK {ECO:0000255|HAMAP-Rule:MF_00400}; GN OrderedLocusNames=Ecok1_15500; ORFNames=APECO1_743; OS Escherichia coli O1:K1 / APEC. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=405955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17293413; DOI=10.1128/jb.01726-06; RA Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., RA Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.; RT "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 RT shares strong similarities with human extraintestinal pathogenic E. coli RT genomes."; RL J. Bacteriol. 189:3228-3236(2007). CC -!- FUNCTION: Multidrug efflux pump that functions probably as a Na(+)/drug CC antiporter. {ECO:0000255|HAMAP-Rule:MF_00400}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP- CC Rule:MF_00400}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_00400}. CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) CC (TC 2.A.66.1) family. MdtK subfamily. {ECO:0000255|HAMAP- CC Rule:MF_00400}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000468; ABJ01044.1; -; Genomic_DNA. DR RefSeq; WP_001174963.1; NZ_CADILS010000002.1. DR AlphaFoldDB; A1ABK4; -. DR SMR; A1ABK4; -. DR KEGG; ecv:APECO1_743; -. DR HOGENOM; CLU_012893_6_0_6; -. DR Proteomes; UP000008216; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule. DR GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:UniProtKB-UniRule. DR CDD; cd13131; MATE_NorM_like; 1. DR HAMAP; MF_00400; MdtK; 1. DR InterPro; IPR002528; MATE_fam. DR InterPro; IPR048279; MdtK-like. DR InterPro; IPR022913; Multidrug-R_MdtK. DR NCBIfam; TIGR00797; matE; 1. DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1. DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1. DR Pfam; PF01554; MatE; 2. DR PIRSF; PIRSF006603; DinF; 1. PE 3: Inferred from homology; KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane; KW Reference proteome; Sodium; Sodium transport; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1..457 FT /note="Multidrug resistance protein MdtK" FT /id="PRO_0000279850" FT TOPO_DOM 1..10 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 11..31 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 32..52 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 53..73 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 74..92 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 93..113 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 114..126 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 127..147 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 148..159 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 160..180 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 181..188 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 189..209 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 210..242 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 243..263 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 264..275 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 276..296 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 297..313 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 314..334 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 335..349 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 350..370 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 371..386 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 387..407 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 408..417 FT /note="Periplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 418..438 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00400" FT TOPO_DOM 439..457 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" SQ SEQUENCE 457 AA; 49430 MW; 3BEAB39CBDDE5CD0 CRC64; MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV LIMLVLWNAG YIIRSMQNID PALADKAVGY LRALLWGAPG YLFFQVARNQ CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ LGLPIALALF FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV VTLAAHLMLL AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL PSGYILALTD LVVEPMGPAG FWIGFIIGLT SAAIMMMLRM RFLQRLPSAI ILQRAAR //