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A1ABK4 (MDTK_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene names
Name:mdtK
Ordered Locus Names:Ecok1_15500
ORF Names:APECO1_743
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity. HAMAP-Rule MF_00400

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00400.

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]

Ontologies

Keywords
   Biological processAntiport
Ion transport
Sodium transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionantiporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

drug transmembrane transporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Multidrug resistance protein MdtK HAMAP-Rule MF_00400
PRO_0000279850

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 5221Periplasmic Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 9219Cytoplasmic Potential
Transmembrane93 – 11321Helical; Potential
Topological domain114 – 12613Periplasmic Potential
Transmembrane127 – 14721Helical; Potential
Topological domain148 – 15912Cytoplasmic Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 1888Periplasmic Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 24233Cytoplasmic Potential
Transmembrane243 – 26321Helical; Potential
Topological domain264 – 27512Periplasmic Potential
Transmembrane276 – 29621Helical; Potential
Topological domain297 – 31317Cytoplasmic Potential
Transmembrane314 – 33421Helical; Potential
Topological domain335 – 34915Periplasmic Potential
Transmembrane350 – 37021Helical; Potential
Topological domain371 – 38616Cytoplasmic Potential
Transmembrane387 – 40721Helical; Potential
Topological domain408 – 41710Periplasmic Potential
Transmembrane418 – 43821Helical; Potential
Topological domain439 – 45719Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
A1ABK4 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 3BEAB39CBDDE5CD0

FASTA45749,430
        10         20         30         40         50         60 
MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG TSIWLPAILF 

        70         80         90        100        110        120 
GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV LIMLVLWNAG YIIRSMQNID 

       130        140        150        160        170        180 
PALADKAVGY LRALLWGAPG YLFFQVARNQ CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY 

       190        200        210        220        230        240 
GHFGMPELGG VGCGVATAAV YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ 

       250        260        270        280        290        300 
LGLPIALALF FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG 

       310        320        330        340        350        360 
YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV VTLAAHLMLL 

       370        380        390        400        410        420 
AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL PSGYILALTD LVVEPMGPAG 

       430        440        450 
FWIGFIIGLT SAAIMMMLRM RFLQRLPSAI ILQRAAR 

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABJ01044.1.
RefSeqYP_852758.1. NC_008563.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_743.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ01044; ABJ01044; APECO1_743.
GeneID4492267.
KEGGecv:APECO1_743.
PATRIC18214944. VBIEscCol127180_1751.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000038538.
KOK03327.
OMAGGVGCGW.
OrthoDBEOG6423C5.

Family and domain databases

HAMAPMF_00400. MdtK.
InterProIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDTK_ECOK1
AccessionPrimary (citable) accession number: A1ABK4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families