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A1ABK4

- MDTK_ECOK1

UniProt

A1ABK4 - MDTK_ECOK1

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Protein

Multidrug resistance protein MdtK

Gene
mdtK, Ecok1_15500, APECO1_743
Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene namesi
Name:mdtK
Ordered Locus Names:Ecok1_15500
ORF Names:APECO1_743
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Topological domaini32 – 5221Periplasmic Reviewed predictionAdd
BLAST
Transmembranei53 – 7321Helical; Reviewed predictionAdd
BLAST
Topological domaini74 – 9219Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Topological domaini114 – 12613Periplasmic Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Topological domaini148 – 15912Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Topological domaini181 – 1888Periplasmic Reviewed prediction
Transmembranei189 – 20921Helical; Reviewed predictionAdd
BLAST
Topological domaini210 – 24233Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Topological domaini264 – 27512Periplasmic Reviewed predictionAdd
BLAST
Transmembranei276 – 29621Helical; Reviewed predictionAdd
BLAST
Topological domaini297 – 31317Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei314 – 33421Helical; Reviewed predictionAdd
BLAST
Topological domaini335 – 34915Periplasmic Reviewed predictionAdd
BLAST
Transmembranei350 – 37021Helical; Reviewed predictionAdd
BLAST
Topological domaini371 – 38616Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei387 – 40721Helical; Reviewed predictionAdd
BLAST
Topological domaini408 – 41710Periplasmic Reviewed prediction
Transmembranei418 – 43821Helical; Reviewed predictionAdd
BLAST
Topological domaini439 – 45719Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKUniRule annotationPRO_0000279850Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405955.APECO1_743.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiGGVGCGW.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1ABK4-1 [UniParc]FASTAAdd to Basket

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MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG    50
TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV 100
LIMLVLWNAG YIIRSMQNID PALADKAVGY LRALLWGAPG YLFFQVARNQ 150
CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV 200
YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ LGLPIALALF 250
FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG 300
YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV 350
VTLAAHLMLL AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL 400
PSGYILALTD LVVEPMGPAG FWIGFIIGLT SAAIMMMLRM RFLQRLPSAI 450
ILQRAAR 457
Length:457
Mass (Da):49,430
Last modified:January 23, 2007 - v1
Checksum:i3BEAB39CBDDE5CD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ01044.1.
RefSeqiYP_852758.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ01044; ABJ01044; APECO1_743.
GeneIDi4492267.
KEGGiecv:APECO1_743.
PATRICi18214944. VBIEscCol127180_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ01044.1 .
RefSeqi YP_852758.1. NC_008563.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ01044 ; ABJ01044 ; APECO1_743 .
GeneIDi 4492267.
KEGGi ecv:APECO1_743.
PATRICi 18214944. VBIEscCol127180_1751.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000038538.
KOi K03327.
OMAi GGVGCGW.
OrthoDBi EOG6423C5.

Family and domain databases

HAMAPi MF_00400. MdtK.
InterProi IPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMDTK_ECOK1
AccessioniPrimary (citable) accession number: A1ABK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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