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Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtKUniRule annotation
Alternative name(s):
Multidrug-efflux transporterUniRule annotation
Gene namesi
Name:mdtKUniRule annotation
Ordered Locus Names:Ecok1_15500
ORF Names:APECO1_743
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Topological domaini32 – 5221PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalUniRule annotationAdd
BLAST
Topological domaini74 – 9219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST
Topological domaini114 – 12613PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalUniRule annotationAdd
BLAST
Topological domaini148 – 15912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalUniRule annotationAdd
BLAST
Topological domaini181 – 1888PeriplasmicSequence Analysis
Transmembranei189 – 20921HelicalUniRule annotationAdd
BLAST
Topological domaini210 – 24233CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Topological domaini264 – 27512PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei276 – 29621HelicalUniRule annotationAdd
BLAST
Topological domaini297 – 31317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei314 – 33421HelicalUniRule annotationAdd
BLAST
Topological domaini335 – 34915PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalUniRule annotationAdd
BLAST
Topological domaini371 – 38616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalUniRule annotationAdd
BLAST
Topological domaini408 – 41710PeriplasmicSequence Analysis
Transmembranei418 – 43821HelicalUniRule annotationAdd
BLAST
Topological domaini439 – 45719CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKPRO_0000279850Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1ABK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG
60 70 80 90 100
TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV
110 120 130 140 150
LIMLVLWNAG YIIRSMQNID PALADKAVGY LRALLWGAPG YLFFQVARNQ
160 170 180 190 200
CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV
210 220 230 240 250
YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ LGLPIALALF
260 270 280 290 300
FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG
310 320 330 340 350
YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV
360 370 380 390 400
VTLAAHLMLL AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL
410 420 430 440 450
PSGYILALTD LVVEPMGPAG FWIGFIIGLT SAAIMMMLRM RFLQRLPSAI

ILQRAAR
Length:457
Mass (Da):49,430
Last modified:January 23, 2007 - v1
Checksum:i3BEAB39CBDDE5CD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ01044.1.
RefSeqiWP_001174963.1. NC_008563.1.
YP_852758.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ01044; ABJ01044; APECO1_743.
KEGGiecv:APECO1_743.
PATRICi18214944. VBIEscCol127180_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ01044.1.
RefSeqiWP_001174963.1. NC_008563.1.
YP_852758.1. NC_008563.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ01044; ABJ01044; APECO1_743.
KEGGiecv:APECO1_743.
PATRICi18214944. VBIEscCol127180_1751.

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMDTK_ECOK1
AccessioniPrimary (citable) accession number: A1ABK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.