Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1ABK4

- MDTK_ECOK1

UniProt

A1ABK4 - MDTK_ECOK1

Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-HAMAP
    2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance protein MdtKUniRule annotation
    Alternative name(s):
    Multidrug-efflux transporterUniRule annotation
    Gene namesi
    Name:mdtKUniRule annotation
    Ordered Locus Names:Ecok1_15500
    ORF Names:APECO1_743
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Multidrug resistance protein MdtKPRO_0000279850Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405955.APECO1_743.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 5221PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini74 – 9219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 12613PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 15912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 1888PeriplasmicSequence Analysis
    Topological domaini210 – 24233CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27512PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 31317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 34915PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini371 – 38616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini408 – 41710PeriplasmicSequence Analysis
    Topological domaini439 – 45719CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei53 – 7321HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei160 – 18021HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei276 – 29621HelicalUniRule annotationAdd
    BLAST
    Transmembranei314 – 33421HelicalUniRule annotationAdd
    BLAST
    Transmembranei350 – 37021HelicalUniRule annotationAdd
    BLAST
    Transmembranei387 – 40721HelicalUniRule annotationAdd
    BLAST
    Transmembranei418 – 43821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000038538.
    KOiK03327.
    OMAiGGVGCGW.
    OrthoDBiEOG6423C5.

    Family and domain databases

    HAMAPiMF_00400. MdtK.
    InterProiIPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1ABK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKYISEARL LLALAIPVIL AQIAQTAMGF VDTVMAGGYS ATDMAAVAIG    50
    TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSV 100
    LIMLVLWNAG YIIRSMQNID PALADKAVGY LRALLWGAPG YLFFQVARNQ 150
    CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV 200
    YWVMFLAMVS YIKRARSMRD IRNEKGTAKP DPAVMKRLIQ LGLPIALALF 250
    FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG 300
    YRLGQGSTLD AQTAARTGLM VGVCMATLTA IFTVSLREQI ALLYNDNPEV 350
    VTLAAHLMLL AAVYQISDSI QVIGSGILRG YKDTRSIFYI TFTAYWVLGL 400
    PSGYILALTD LVVEPMGPAG FWIGFIIGLT SAAIMMMLRM RFLQRLPSAI 450
    ILQRAAR 457
    Length:457
    Mass (Da):49,430
    Last modified:January 23, 2007 - v1
    Checksum:i3BEAB39CBDDE5CD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ01044.1.
    RefSeqiYP_852758.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ01044; ABJ01044; APECO1_743.
    GeneIDi4492267.
    KEGGiecv:APECO1_743.
    PATRICi18214944. VBIEscCol127180_1751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ01044.1 .
    RefSeqi YP_852758.1. NC_008563.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ01044 ; ABJ01044 ; APECO1_743 .
    GeneIDi 4492267.
    KEGGi ecv:APECO1_743.
    PATRICi 18214944. VBIEscCol127180_1751.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000038538.
    KOi K03327.
    OMAi GGVGCGW.
    OrthoDBi EOG6423C5.

    Family and domain databases

    HAMAPi MF_00400. MdtK.
    InterProi IPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMDTK_ECOK1
    AccessioniPrimary (citable) accession number: A1ABK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3