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Protein

Dihydromonapterin reductase

Gene

folM

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate.By similarity

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.By similarity
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processOne-carbon metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydromonapterin reductase (EC:1.5.1.-)
Short name:
H(2)-MPt reductase
Alternative name(s):
Dihydrofolate reductase (EC:1.5.1.3)
Short name:
DHFR
Gene namesi
Name:folM
Ordered Locus Names:Ecok1_14970
ORF Names:APECO1_689
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003393941 – 240Dihydromonapterin reductaseAdd BLAST240

Proteomic databases

PRIDEiA1ABF1

Structurei

3D structure databases

ProteinModelPortaliA1ABF1
SMRiA1ABF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK13938
OMAiPALLMFN

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

A1ABF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTQSLPIL ITGGGRRIGL ALAWHFINQK QPVIVSYRTH YPAIDGLIKA
60 70 80 90 100
GAQCIQADFS TNDGVMAFAD EVLKSTHGLR AILHNASAWM AEKPGAPLTD
110 120 130 140 150
VLACMMQIHV NTPYLLNHAL ERLLRGHGHA ASDIIHFTDY VVERGSDKHI
160 170 180 190 200
AYAASKAALD NMTRSFARKL APEVKVNSIA PSLILFNEHD DAEYRQQALN
210 220 230 240
KSLMKTAPGE KEVIDLVDYL LTSCFVTGRS FPLDGGRHLR
Length:240
Mass (Da):26,382
Last modified:January 23, 2007 - v1
Checksum:i72A10AE1D7EB6C4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA Translation: ABJ00991.1
RefSeqiWP_000520811.1, NC_008563.1

Genome annotation databases

EnsemblBacteriaiABJ00991; ABJ00991; APECO1_689
KEGGiecv:APECO1_689

Entry informationi

Entry nameiFOLM_ECOK1
AccessioniPrimary (citable) accession number: A1ABF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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