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A1ABA1

- UXAB_ECOK1

UniProt

A1ABA1 - UXAB_ECOK1

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Protein
Altronate oxidoreductase
Gene
uxaB, Ecok1_14470, APECO1_641
Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 2912NAD By similarity
Add
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Altronate oxidoreductase (EC:1.1.1.58)
    Alternative name(s):
    Tagaturonate dehydrogenase
    Tagaturonate reductase
    Gene namesi
    Name:uxaB
    Ordered Locus Names:Ecok1_14470
    ORF Names:APECO1_641
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Altronate oxidoreductaseUniRule annotation
    PRO_1000044702Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405955.APECO1_641.

    Structurei

    3D structure databases

    ProteinModelPortaliA1ABA1.
    SMRiA1ABA1. Positions 2-482.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000029586.
    KOiK00041.
    OMAiHNTFCST.
    OrthoDBiEOG6CVVB8.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00670. Altron_oxidoreduct.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1ABA1-1 [UniParc]FASTAAdd to Basket

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    MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV    50
    VRPIETSFPP SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS 100
    EYDEFLKLAH NPEMRFVFSN TTEAGISYHA GDKFDDAPAV SYPAKLTRLL 150
    FERFSHFNGA LDKGWIIIPC ELIDYNGDAL RELVLRYAQE WALPEAFIQW 200
    LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT AEHFYLFVIQ 250
    GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 300
    LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP 350
    YIKHQLLSIA LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY 400
    RGERNGETYP VQDDAHWLER YQQLWSQYRD RVIGTQELVA IVLAEKDHWE 450
    QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC 483
    Length:483
    Mass (Da):54,834
    Last modified:January 23, 2007 - v1
    Checksum:i4EA4766DF35BC2FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00941.1.
    RefSeqiYP_852655.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ00941; ABJ00941; APECO1_641.
    GeneIDi4493398.
    KEGGiecv:APECO1_641.
    PATRICi18214710. VBIEscCol127180_1634.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00941.1 .
    RefSeqi YP_852655.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1ABA1.
    SMRi A1ABA1. Positions 2-482.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ00941 ; ABJ00941 ; APECO1_641 .
    GeneIDi 4493398.
    KEGGi ecv:APECO1_641.
    PATRICi 18214710. VBIEscCol127180_1634.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000029586.
    KOi K00041.
    OMAi HNTFCST.
    OrthoDBi EOG6CVVB8.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00670. Altron_oxidoreduct.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUXAB_ECOK1
    AccessioniPrimary (citable) accession number: A1ABA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 23, 2007
    Last modified: May 14, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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