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A1AB81

- A1AB81_ECOK1

UniProt

A1AB81 - A1AB81_ECOK1

Protein

Glutamate decarboxylase

Gene

gadA

Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadAImported
    ORF Names:APECO1_621Imported
    OrganismiEscherichia coli O1:K1 / APECImported
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1AB81-1 [UniParc]FASTAAdd to Basket

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    MRDDVAFQII NDELYLDGNA RQNLATFCQT WDDXNVHKLM DLSINKNWID    50
    KEEYPQSAAI DLRCVNMVAD LWHAPAPKNG QAVGTNTIGS SEACMLGGMA 100
    MKWRWRKRME AAGKPTNKPN LVCGPVQICW HKFARYWDVE LREIPMRPGQ 150
    LFMDPKRMIE ACDENTIGVV PTFGVTYTGN YEFPQPLHDA LDKFQADTGI 200
    DIDMHIDAAS GGFLAPFVAP DIVWDFRLPR VKSISASGHK FGLAPLGCGW 250
    VIWRDEEALP QELVFNVDYL GGQIGTFAIN FSRPAGQVIA QYYEFLRLGR 300
    EGYTKVQNAS YQVAAYLADE IAKLGPYEFI CTGRPDEGIP AVCFKLKDGE 350
    DPGYTLYDLS ERLRLRGWQV PAFTLGGEAT DIVVMRIMCR RGFEMDFAEL 400
    LLEDYKASLK YLSDHPKLQG IAQQNSFKHT 430
    Length:430
    Mass (Da):48,533
    Last modified:January 23, 2007 - v1
    Checksum:i8A9494AA2356751E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00921.1.
    RefSeqiWP_011703568.1. NC_008563.1.
    YP_852635.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ00921; ABJ00921; APECO1_621.
    GeneIDi4494407.
    KEGGiecv:APECO1_621.
    PATRICi18214666. VBIEscCol127180_1612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00921.1 .
    RefSeqi WP_011703568.1. NC_008563.1.
    YP_852635.1. NC_008563.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ00921 ; ABJ00921 ; APECO1_621 .
    GeneIDi 4494407.
    KEGGi ecv:APECO1_621.
    PATRICi 18214666. VBIEscCol127180_1612.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OrthoDBi EOG6TFCPW.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APEC O1Imported.

    Entry informationi

    Entry nameiA1AB81_ECOK1
    AccessioniPrimary (citable) accession number: A1AB81
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3