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A1AB81

- A1AB81_ECOK1

UniProt

A1AB81 - A1AB81_ECOK1

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Protein

Glutamate decarboxylase

Gene

gadA

Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadAImported
ORF Names:APECO1_621Imported
OrganismiEscherichia coli O1:K1 / APECImported
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1AB81-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRDDVAFQII NDELYLDGNA RQNLATFCQT WDDXNVHKLM DLSINKNWID
60 70 80 90 100
KEEYPQSAAI DLRCVNMVAD LWHAPAPKNG QAVGTNTIGS SEACMLGGMA
110 120 130 140 150
MKWRWRKRME AAGKPTNKPN LVCGPVQICW HKFARYWDVE LREIPMRPGQ
160 170 180 190 200
LFMDPKRMIE ACDENTIGVV PTFGVTYTGN YEFPQPLHDA LDKFQADTGI
210 220 230 240 250
DIDMHIDAAS GGFLAPFVAP DIVWDFRLPR VKSISASGHK FGLAPLGCGW
260 270 280 290 300
VIWRDEEALP QELVFNVDYL GGQIGTFAIN FSRPAGQVIA QYYEFLRLGR
310 320 330 340 350
EGYTKVQNAS YQVAAYLADE IAKLGPYEFI CTGRPDEGIP AVCFKLKDGE
360 370 380 390 400
DPGYTLYDLS ERLRLRGWQV PAFTLGGEAT DIVVMRIMCR RGFEMDFAEL
410 420 430
LLEDYKASLK YLSDHPKLQG IAQQNSFKHT
Length:430
Mass (Da):48,533
Last modified:January 23, 2007 - v1
Checksum:i8A9494AA2356751E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ00921.1.
RefSeqiWP_011703568.1. NC_008563.1.
YP_852635.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ00921; ABJ00921; APECO1_621.
GeneIDi4494407.
KEGGiecv:APECO1_621.
PATRICi18214666. VBIEscCol127180_1612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABJ00921.1 .
RefSeqi WP_011703568.1. NC_008563.1.
YP_852635.1. NC_008563.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ00921 ; ABJ00921 ; APECO1_621 .
GeneIDi 4494407.
KEGGi ecv:APECO1_621.
PATRICi 18214666. VBIEscCol127180_1612.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
KOi K01580.
OrthoDBi EOG6TFCPW.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APEC O1Imported.

Entry informationi

Entry nameiA1AB81_ECOK1
AccessioniPrimary (citable) accession number: A1AB81
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3