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A1AAQ6

- A1AAQ6_ECOK1

UniProt

A1AAQ6 - A1AAQ6_ECOK1

Protein

Enoyl-[acyl-carrier-protein] reductase [NADH]

Gene

fabI

Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation
    Active sitei146 – 1461Proton acceptorUniRule annotation
    Active sitei156 – 1561Proton acceptorUniRule annotation
    Sitei201 – 2011Involved in acyl-ACP bindingUniRule annotation
    Sitei204 – 2041Involved in acyl-ACP bindingUniRule annotation
    Sitei205 – 2051Involved in acyl-ACP bindingUniRule annotation

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]UniRule annotation (EC:1.3.1.9UniRule annotation)
    Gene namesi
    Name:fabIImported
    ORF Names:APECO1_447Imported
    OrganismiEscherichia coli O1:K1 / APECImported
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiA1AAQ6.

    Interactioni

    Protein-protein interaction databases

    STRINGi405955.APECO1_447.

    Structurei

    3D structure databases

    ProteinModelPortaliA1AAQ6.
    SMRiA1AAQ6. Positions 2-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0623.
    KOiK00208.
    OMAiAMEISAY.
    OrthoDBiEOG6HF644.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    A1AAQ6-1 [UniParc]FASTAAdd to Basket

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    MGFLSGKRIL VTGVASKLSI AYGIAQAMHR EGAELAFTYQ NDKLKGRVEE    50
    FAAQLGSDIV LQCDVAEDAS IDTMFAELGK VWPKFDGFVH SIGFAPGDQL 100
    DGDYVNAVTR EGFKIAHDIS SYSFVAMAKA CRSMLNPGSA LLTLSYLGAE 150
    RAIPNYNVMG LAKASLEANV RYMANAMGPE GVRVNAISAG PIRTLAASGI 200
    KDFRKMLAHC EAVTPIRRTV TIEDVGNSAA FLCSDLSAGI SGEVVHVDGG 250
    FSIAAMNELE LK 262
    Length:262
    Mass (Da):27,864
    Last modified:January 23, 2007 - v1
    Checksum:i436A89AF349D1866
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00746.1.
    RefSeqiYP_852460.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ00746; ABJ00746; APECO1_447.
    GeneIDi4492237.
    KEGGiecv:APECO1_447.
    PATRICi18214239. VBIEscCol127180_1402.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00746.1 .
    RefSeqi YP_852460.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1AAQ6.
    SMRi A1AAQ6. Positions 2-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_447.

    Chemistry

    BindingDBi A1AAQ6.

    Proteomic databases

    PRIDEi A1AAQ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ00746 ; ABJ00746 ; APECO1_447 .
    GeneIDi 4492237.
    KEGGi ecv:APECO1_447.
    PATRICi 18214239. VBIEscCol127180_1402.

    Phylogenomic databases

    eggNOGi COG0623.
    KOi K00208.
    OMAi AMEISAY.
    OrthoDBi EOG6HF644.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APEC O1Imported.

    Entry informationi

    Entry nameiA1AAQ6_ECOK1
    AccessioniPrimary (citable) accession number: A1AAQ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3