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Protein

Thiamine kinase

Gene

thiK

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of thiamine to thiamine phosphate.UniRule annotation

Catalytic activityi

ATP + thiamine = ADP + thiamine phosphate.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes thiamine phosphate from thiamine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Thiamine kinase (thiK)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine phosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00596.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine kinaseUniRule annotation (EC:2.7.1.89UniRule annotation)
Gene namesi
Name:thiKUniRule annotation
Ordered Locus Names:Ecok1_09960
ORF Names:APECO1_187
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008216 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Thiamine kinasePRO_0000290996Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1AA00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiamine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219316.
KOiK07251.
OMAiDYLVLMW.

Family and domain databases

HAMAPiMF_01604. Thiamine_kinase. 1 hit.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
IPR014093. Thiamine_kinase.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR02721. ycfN_thiK. 1 hit.

Sequencei

Sequence statusi: Complete.

A1AA00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFRSNNPLT RDELLSRFFP QFHPVTTFNS GLSGGSFLIE HQGQRFVVRQ
60 70 80 90 100
PHDPDAPQSA FLRQYRALSQ LPACIAPKPH LYLRDWMVVD YLPGEVKTYL
110 120 130 140 150
PDTNELAGLL YYLHQQPRFG WRITLLPLLE LYWQQSDPAR RTVGWLRMLK
160 170 180 190 200
RLRKAREPRL LRLSPLHMDV HAGNLVHSAS GLKLIDWEYA GDGDIALELA
210 220 230 240 250
AVWVENIDQH RQLVNDYATR AKIYPAQLWR QVRRWFPWLL MLKAGWFEYR
260 270
WRQTGDQQFI RLADDTWRQL LIKQ
Length:274
Mass (Da):32,453
Last modified:January 23, 2007 - v1
Checksum:i747FB1E5F907AD84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ00490.1.
RefSeqiWP_001116600.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABJ00490; ABJ00490; APECO1_187.
KEGGiecv:APECO1_187.
PATRICi18213648. VBIEscCol127180_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABJ00490.1.
RefSeqiWP_001116600.1. NC_008563.1.

3D structure databases

ProteinModelPortaliA1AA00.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ00490; ABJ00490; APECO1_187.
KEGGiecv:APECO1_187.
PATRICi18213648. VBIEscCol127180_1110.

Phylogenomic databases

HOGENOMiHOG000219316.
KOiK07251.
OMAiDYLVLMW.

Enzyme and pathway databases

UniPathwayiUPA00060; UER00596.

Family and domain databases

HAMAPiMF_01604. Thiamine_kinase. 1 hit.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
IPR014093. Thiamine_kinase.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR02721. ycfN_thiK. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHIK_ECOK1
AccessioniPrimary (citable) accession number: A1AA00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.