Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1A9S3

- EFEB_ECOK1

UniProt

A1A9S3 - EFEB_ECOK1

Protein

Deferrochelatase/peroxidase EfeB

Gene

efeB

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact By similarity.By similarity

    Cofactori

    Binds 1 heme B (iron-protoporphyrin IX) group non-covalently per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi329 – 3291Iron (heme proximal ligand); via tele nitrogenBy similarity
    Binding sitei347 – 3471HemeBy similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. peroxidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Protein family/group databases

    PeroxiBasei5878. EcoDyPrx01_APECO1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deferrochelatase/peroxidase EfeB (EC:1.11.1.-)
    Gene namesi
    Name:efeB
    Ordered Locus Names:Ecok1_09190
    OrganismiEscherichia coli O1:K1 / APEC
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Chaini36 – 423388Deferrochelatase/peroxidase EfeBPRO_0000278545Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Interactioni

    Subunit structurei

    Homodimer. Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB By similarity.By similarity

    Protein-protein interaction databases

    STRINGi405955.APECO1_110.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A9S3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni236 – 2383Heme bindingBy similarity
    Regioni334 – 3363Heme bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2837.
    KOiK16301.
    OMAiLPPMDSG.
    OrthoDBiEOG6F55G9.

    Family and domain databases

    InterProiIPR011008. Dimeric_a/b-barrel.
    IPR006314. Dyp_peroxidase.
    IPR006313. EfeB.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF04261. Dyp_perox. 1 hit.
    [Graphical view]
    SUPFAMiSSF54909. SSF54909. 1 hit.
    TIGRFAMsiTIGR01413. Dyp_perox_fam. 1 hit.
    TIGR01412. tat_substr_1. 1 hit.
    PROSITEiPS51404. DYP_PEROXIDASE. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1A9S3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQYEDENGVN EPSRRRLLKG IGALALAGSC PVAHAQKTQS APGTLSPDAR    50
    NEKQPFYGEH QAGILTPQQA AMMLVAFDVL ASDKADLERL FRLLTQRFAF 100
    LTQGGAAPET PNPRLPPLDS GILGGYIAPD NLTITLSVGH SLFDERFGLA 150
    PQMPKKLQKM TRFPNDSLDA ALCHGDVLLQ ICANTQDTVI HALRDIIKHT 200
    PDLLSVRWKR EGFISDHAAR SKGKETPINL LGFKDGTANP DSQNDKLMQK 250
    VVWVTADQQE PAWTIGGSYQ AVRLIQFRVE FWDRTPLKEQ QTIFGRDKQT 300
    GAPLGMLHEH DVPDYASDPE GKVIALDSHI RLANPRTAES ESSLMLRRGY 350
    SYSLGVTNSG QLDMGLLFVC YQHDLEKGFL TVQKRLNGEA LEEYVKPIGG 400
    GYFFALSGVK DANDYLGSAL LRV 423
    Length:423
    Mass (Da):46,654
    Last modified:January 23, 2007 - v1
    Checksum:i9EB660519206CD2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00413.1.
    RefSeqiYP_852127.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABJ00413; ABJ00413; APECO1_110.
    GeneIDi4495215.
    KEGGiecv:APECO1_110.
    PATRICi18213474. VBIEscCol127180_1024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABJ00413.1 .
    RefSeqi YP_852127.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1A9S3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_110.

    Protein family/group databases

    PeroxiBasei 5878. EcoDyPrx01_APECO1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ00413 ; ABJ00413 ; APECO1_110 .
    GeneIDi 4495215.
    KEGGi ecv:APECO1_110.
    PATRICi 18213474. VBIEscCol127180_1024.

    Phylogenomic databases

    eggNOGi COG2837.
    KOi K16301.
    OMAi LPPMDSG.
    OrthoDBi EOG6F55G9.

    Family and domain databases

    InterProi IPR011008. Dimeric_a/b-barrel.
    IPR006314. Dyp_peroxidase.
    IPR006313. EfeB.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF04261. Dyp_perox. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54909. SSF54909. 1 hit.
    TIGRFAMsi TIGR01413. Dyp_perox_fam. 1 hit.
    TIGR01412. tat_substr_1. 1 hit.
    PROSITEi PS51404. DYP_PEROXIDASE. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiEFEB_ECOK1
    AccessioniPrimary (citable) accession number: A1A9S3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3