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A1A909 (6PGL_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconolactonase
Short name=6-P-gluconolactonase
EC=3.1.1.31
Gene names
Name:pgl
Ordered Locus Names:Ecok1_06550
ORF Names:APECO1_1322
OrganismEscherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]
Taxonomic identifier405955 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity. HAMAP MF_01605

Catalytic activity

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. HAMAP MF_01605

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. HAMAP MF_01605

Sequence similarities

Belongs to the cycloisomerase 2 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   Molecular functionHydrolase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpentose-phosphate shunt

Inferred from electronic annotation. Source: InterPro

   Molecular function6-phosphogluconolactonase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3313316-phosphogluconolactonase HAMAP MF_01605
PRO_0000291466

Amino acid modifications

Modified residue2871N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1A909 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 457820D7279EAC52

FASTA33136,293
        10         20         30         40         50         60 
MKQTVYIASP ESQQIHVWNL NHEGALTLTQ VVDVPGQVQP MVVSPDKRYL YVGVRPEFRV 

        70         80         90        100        110        120 
LAYRIAPDDG ALTFAAESAL PGSPTHISTD HLGQFVFVGS YNAGNVSVTR LEDGLPVGVV 

       130        140        150        160        170        180 
DVVEGLDGCH SANISPDNRT LWVPALKQDR ICLFTVSDDG HLVAQDPAEV TTVEGAGPRH 

       190        200        210        220        230        240 
MVFHPNEQYA YCVNELNSSV DVWELKDPHG NIECVQTLDM MPENFSDTRW AADIHITPDG 

       250        260        270        280        290        300 
RHLYACDRTA SLITVFSVSE DGSVLSKEGF QPTETQPRGF NVDHSGKYLI AAGQKSHHIS 

       310        320        330 
VYEIVGEQGL LHEKGRYAVG QGPMWVVVNA H

« Hide

References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed: 17293413] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000468 Genomic DNA. Translation: ABJ00149.1.
RefSeqYP_851863.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1A909.
SMRA1A909. Positions 1-331.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1A909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000038666; EBESCP00000037183; EBESCG00000037716.
GeneID4493439.
GenomeReviewsGene locus Ecok1_06550 in contig CP000468_GR.
KEGGecv:APECO1_1322.
PATRIC18212870. VBIEscCol127180_0724.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2706.
GeneTreeEBGT00050000009586.
HOGENOMHBG741123.
OMACINELNS.
ProtClustDBPRK11028.

Enzyme and pathway databases

BioCycECOL405955:APECO1_1322-MONOMER.

Family and domain databases

HAMAPMF_01605. 6P-gluconolactonase.
[Tree]
InterProIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KOK07404.
PfamPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMSSF50974. N2O_reductase_N. 1 hit.
ProtoNetSearch...

Entry information

Entry name6PGL_ECOK1
AccessionPrimary (citable) accession number: A1A909
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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