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A1A8H5

- A1A8H5_ECOK1

UniProt

A1A8H5 - A1A8H5_ECOK1

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Protein
Submitted name:

2-hydroxy-3-oxopropionate reductase

Gene
ybbQ, APECO1_1505
Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691 By similarityUniRule annotation

GO - Molecular functioni

  1. 2-hydroxy-3-oxopropionate reductase activity Source: InterPro
  2. 3-hydroxyisobutyrate dehydrogenase activity Source: InterPro
  3. NAD binding Source: InterPro
  4. phosphogluconate dehydrogenase (decarboxylating) activity Source: InterPro

GO - Biological processi

  1. glyoxylate metabolic process Source: InterPro
  2. pentose-phosphate shunt Source: InterPro
  3. valine metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-hydroxy-3-oxopropionate reductaseImported
Gene namesi
Name:ybbQImported
ORF Names:APECO1_1505Imported
OrganismiEscherichia coli O1:K1 / APECImported
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi405955.APECO1_1505.

Structurei

3D structure databases

ProteinModelPortaliA1A8H5.
SMRiA1A8H5. Positions 1-291.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2084.
HOGENOMiHOG000219608.
KOiK00042.
OMAiELMNACA.
OrthoDBiEOG6XDH0X.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR015815. HIBADH-type.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR006398. Tartro_sem_red.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR01505. tartro_sem_red. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A8H5-1 [UniParc]FASTAAdd to Basket

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MKLGFIGLGI MGTPMAINLA RAGHQLHVTT IGPVADELLS LGAVSVETAR    50
QVTDASDIIF IMVPDTPQVE DVLFGENGCT KASLKGKTIV DMSSISPIET 100
KRFARQVNEL GGDYLDAPVS GGEIGAREGT LSIMVGGDEA VFERVKPLFE 150
LLGKNITLVG GNGDGQTCKV ANQIIVALNI EAVSEALLFA SKAGADPVRV 200
RQALMGGFAS SRILEVHGER MIKRTFNPGF KIALHQKDLN LALQSAKALA 250
LNLPNTATCQ ELFNTCAANG GSQLDHSALV QALELMANHK LA 292
Length:292
Mass (Da):30,773
Last modified:January 23, 2007 - v1
Checksum:iA59DBF19CC846B66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABI99964.1.
RefSeqiYP_851679.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABI99964; ABI99964; APECO1_1505.
GeneIDi4493622.
KEGGiecv:APECO1_1505.
PATRICi18212422. VBIEscCol127180_0515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABI99964.1 .
RefSeqi YP_851679.1. NC_008563.1.

3D structure databases

ProteinModelPortali A1A8H5.
SMRi A1A8H5. Positions 1-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_1505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI99964 ; ABI99964 ; APECO1_1505 .
GeneIDi 4493622.
KEGGi ecv:APECO1_1505.
PATRICi 18212422. VBIEscCol127180_0515.

Phylogenomic databases

eggNOGi COG2084.
HOGENOMi HOG000219608.
KOi K00042.
OMAi ELMNACA.
OrthoDBi EOG6XDH0X.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR015815. HIBADH-type.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR006398. Tartro_sem_red.
[Graphical view ]
Pfami PF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000103. HIBADH. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR01505. tartro_sem_red. 1 hit.
PROSITEi PS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APEC O1Imported.

Entry informationi

Entry nameiA1A8H5_ECOK1
AccessioniPrimary (citable) accession number: A1A8H5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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