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Protein
Submitted name:

2-hydroxy-3-oxopropionate reductase

Gene

ybbQ

Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691UniRule annotation

GO - Molecular functioni

  1. 2-hydroxy-3-oxopropionate reductase activity Source: InterPro
  2. 3-hydroxyisobutyrate dehydrogenase activity Source: InterPro
  3. NAD binding Source: InterPro
  4. phosphogluconate dehydrogenase (decarboxylating) activity Source: InterPro

GO - Biological processi

  1. glyoxylate metabolic process Source: InterPro
  2. pentose-phosphate shunt Source: InterPro
  3. valine metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-hydroxy-3-oxopropionate reductaseImported
Gene namesi
Name:ybbQImported
ORF Names:APECO1_1505Imported
OrganismiEscherichia coli O1:K1 / APECImported
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi405955.APECO1_1505.

Structurei

3D structure databases

ProteinModelPortaliA1A8H5.
SMRiA1A8H5. Positions 1-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2084.
HOGENOMiHOG000219608.
KOiK00042.
OMAiMVKRTFN.
OrthoDBiEOG6XDH0X.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR015815. HIBADH-type.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR006398. Tartro_sem_red.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR01505. tartro_sem_red. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A8H5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLGFIGLGI MGTPMAINLA RAGHQLHVTT IGPVADELLS LGAVSVETAR
60 70 80 90 100
QVTDASDIIF IMVPDTPQVE DVLFGENGCT KASLKGKTIV DMSSISPIET
110 120 130 140 150
KRFARQVNEL GGDYLDAPVS GGEIGAREGT LSIMVGGDEA VFERVKPLFE
160 170 180 190 200
LLGKNITLVG GNGDGQTCKV ANQIIVALNI EAVSEALLFA SKAGADPVRV
210 220 230 240 250
RQALMGGFAS SRILEVHGER MIKRTFNPGF KIALHQKDLN LALQSAKALA
260 270 280 290
LNLPNTATCQ ELFNTCAANG GSQLDHSALV QALELMANHK LA
Length:292
Mass (Da):30,773
Last modified:January 23, 2007 - v1
Checksum:iA59DBF19CC846B66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABI99964.1.
RefSeqiYP_851679.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABI99964; ABI99964; APECO1_1505.
GeneIDi4493622.
KEGGiecv:APECO1_1505.
PATRICi18212422. VBIEscCol127180_0515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA. Translation: ABI99964.1.
RefSeqiYP_851679.1. NC_008563.1.

3D structure databases

ProteinModelPortaliA1A8H5.
SMRiA1A8H5. Positions 1-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405955.APECO1_1505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI99964; ABI99964; APECO1_1505.
GeneIDi4493622.
KEGGiecv:APECO1_1505.
PATRICi18212422. VBIEscCol127180_0515.

Phylogenomic databases

eggNOGiCOG2084.
HOGENOMiHOG000219608.
KOiK00042.
OMAiMVKRTFN.
OrthoDBiEOG6XDH0X.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR015815. HIBADH-type.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR006398. Tartro_sem_red.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR01505. tartro_sem_red. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APEC O1Imported.

Entry informationi

Entry nameiA1A8H5_ECOK1
AccessioniPrimary (citable) accession number: A1A8H5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.