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A1A8H5

- A1A8H5_ECOK1

UniProt

A1A8H5 - A1A8H5_ECOK1

Protein
Submitted name:

2-hydroxy-3-oxopropionate reductase

Gene

ybbQ

Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei169 – 1691UniRule annotation

    GO - Molecular functioni

    1. 2-hydroxy-3-oxopropionate reductase activity Source: InterPro
    2. 3-hydroxyisobutyrate dehydrogenase activity Source: InterPro
    3. NAD binding Source: InterPro
    4. phosphogluconate dehydrogenase (decarboxylating) activity Source: InterPro

    GO - Biological processi

    1. glyoxylate metabolic process Source: InterPro
    2. pentose-phosphate shunt Source: InterPro
    3. valine metabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-hydroxy-3-oxopropionate reductaseImported
    Gene namesi
    Name:ybbQImported
    ORF Names:APECO1_1505Imported
    OrganismiEscherichia coli O1:K1 / APECImported
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi405955.APECO1_1505.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A8H5.
    SMRiA1A8H5. Positions 1-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2084.
    HOGENOMiHOG000219608.
    KOiK00042.
    OMAiELMNACA.
    OrthoDBiEOG6XDH0X.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR006115. 6PGDH_NADP-bd.
    IPR013328. DH_multihelical.
    IPR015815. HIBADH-type.
    IPR016040. NAD(P)-bd_dom.
    IPR029154. NADP-bd.
    IPR006398. Tartro_sem_red.
    [Graphical view]
    PfamiPF14833. NAD_binding_11. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000103. HIBADH. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR01505. tartro_sem_red. 1 hit.
    PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A8H5-1 [UniParc]FASTAAdd to Basket

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    MKLGFIGLGI MGTPMAINLA RAGHQLHVTT IGPVADELLS LGAVSVETAR    50
    QVTDASDIIF IMVPDTPQVE DVLFGENGCT KASLKGKTIV DMSSISPIET 100
    KRFARQVNEL GGDYLDAPVS GGEIGAREGT LSIMVGGDEA VFERVKPLFE 150
    LLGKNITLVG GNGDGQTCKV ANQIIVALNI EAVSEALLFA SKAGADPVRV 200
    RQALMGGFAS SRILEVHGER MIKRTFNPGF KIALHQKDLN LALQSAKALA 250
    LNLPNTATCQ ELFNTCAANG GSQLDHSALV QALELMANHK LA 292
    Length:292
    Mass (Da):30,773
    Last modified:January 23, 2007 - v1
    Checksum:iA59DBF19CC846B66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABI99964.1.
    RefSeqiYP_851679.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABI99964; ABI99964; APECO1_1505.
    GeneIDi4493622.
    KEGGiecv:APECO1_1505.
    PATRICi18212422. VBIEscCol127180_0515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABI99964.1 .
    RefSeqi YP_851679.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1A8H5.
    SMRi A1A8H5. Positions 1-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_1505.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI99964 ; ABI99964 ; APECO1_1505 .
    GeneIDi 4493622.
    KEGGi ecv:APECO1_1505.
    PATRICi 18212422. VBIEscCol127180_0515.

    Phylogenomic databases

    eggNOGi COG2084.
    HOGENOMi HOG000219608.
    KOi K00042.
    OMAi ELMNACA.
    OrthoDBi EOG6XDH0X.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR002204. 3-OH-isobutyrate_DH-rel_CS.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR006115. 6PGDH_NADP-bd.
    IPR013328. DH_multihelical.
    IPR015815. HIBADH-type.
    IPR016040. NAD(P)-bd_dom.
    IPR029154. NADP-bd.
    IPR006398. Tartro_sem_red.
    [Graphical view ]
    Pfami PF14833. NAD_binding_11. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000103. HIBADH. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR01505. tartro_sem_red. 1 hit.
    PROSITEi PS00895. 3_HYDROXYISOBUT_DH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APEC O1Imported.

    Entry informationi

    Entry nameiA1A8H5_ECOK1
    AccessioniPrimary (citable) accession number: A1A8H5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3