A1A8H2 (ALLR_ECOK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional repressor AllR

Alternative name(s):
Negative regulator of allantoin and glyoxylate utilization operons

Gene names

Name:	allR
Ordered Locus Names:	Ecok1_04680
ORF Names:	APECO1_1508

Organism

Escherichia coli O1:K1 / APEC [Complete proteome] [HAMAP]

Taxonomic identifier

405955 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region By similarity.
Sequence similarities	Contains 1 HTH iclR-type DNA-binding domain. Contains 1 iclR-ED (iclR effector binding) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	HTH-type transcriptional repressor AllR		PRO_0000313699
Regions
	Domain	21 – 83	63	HTH iclR-type
	Domain	98 – 267	170	IclR-ED
	DNA binding	43 – 62	20	H-T-H motif By similarity
	Region	154 – 156	3	Glyoxylate binding By similarity
	Region	234 – 236	3	Glyoxylate binding By similarity
Sites
	Binding site	207	1	Glyoxylate By similarity
	Binding site	217	1	Glyoxylate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1A8H2 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 572F59EEC0F8308B	FASTA	271	29,286
	10 20 30 40 50 60 MTEVRRRGRP GQAEPVAQKG AQALERGIAI LQYLEKSGGS SSVSDISLNL DLPLSTTFRL 70 80 90 100 110 120 LKVLQAADFV YQDSQLGWWH IGLGVFNVGA AYIHNRDVLS VAGPFMRRLM LLSGETVNVA 130 140 150 160 170 180 IRNGNEAVLI GQLECKSMVR MCAPLGSRLP LHASGAGKAL LYPLAEEELM SIILQTGLQQ 190 200 210 220 230 240 FTPTTLVDMP TLLKDLEQAR ELGYTVDKEE HVVGLNCIAS AIYDDVGSVV AAISISGPSS 250 260 270 RLTEDRFVSQ GELVRDTARD ISTALGLKAH L

References

[1]

"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes." Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K. J. Bacteriol. 189:3228-3236(2007) [PubMed: 17293413] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000468 Genomic DNA. Translation: ABI99961.1.
RefSeq	YP_851676.1. NC_008563.1.
3D structure databases
ProteinModelPortal	A1A8H2.
SMR	A1A8H2. Positions 19-270.
ModBase	Search...
Protein-protein interaction databases
STRING	A1A8H2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000039475; EBESCP00000037992; EBESCG00000038525.
GeneID	4493619.
GenomeReviews	Gene locus Ecok1_04680 in contig CP000468_GR.
KEGG	ecv:APECO1_1508.
PATRIC	18212416. VBIEscCol127180_0512.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1414.
GeneTree	EBGT00050000008790.
HOGENOM	HBG739407.
OMA	VFRILAT.
ProtClustDB	PRK10163.
Enzyme and pathway databases
BioCyc	ECOL405955:APECO1_1508-MONOMER.
Family and domain databases
InterPro	IPR014757. Tscrpt_reg_IclR_C. IPR005471. Tscrpt_reg_IclR_N. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KO	K10973.
Pfam	PF09339. HTH_IclR. 1 hit. PF01614. IclR. 1 hit. [Graphical view]
SMART	SM00346. HTH_ICLR. 1 hit. [Graphical view]
PROSITE	PS51077. HTH_ICLR. 1 hit. PS51078. ICLR_ED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	A1A8H2.

Entry information

Entry name

ALLR_ECOK1

Accession

Primary (citable) accession number: A1A8H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program