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A1A7Q5

- A1A7Q5_ECOK1

UniProt

A1A7Q5 - A1A7Q5_ECOK1

Protein

Ribonuclease H

Gene

rnhA

Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotationSAAS annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Magnesium 1UniRule annotation
    Metal bindingi47 – 471Magnesium 2UniRule annotation
    Metal bindingi85 – 851Magnesium 1UniRule annotation
    Metal bindingi107 – 1071Magnesium 1UniRule annotation
    Metal bindingi171 – 1711Magnesium 2UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. nucleic acid binding Source: InterPro
    3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. RNA catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease HUniRule annotation (EC:3.1.26.4UniRule annotation)
    Short name:
    RNase HUniRule annotation
    Gene namesi
    Name:rnhAUniRule annotationImported
    ORF Names:APECO1_1776Imported
    OrganismiEscherichia coli O1:K1 / APECImported
    Taxonomic identifieri405955 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008216: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi405955.APECO1_1776.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A7Q5.
    SMRiA1A7Q5. Positions 38-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 179142RNase HUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RNase H family.UniRule annotation
    Contains 1 RNase H domain.UniRule annotation
    Contains RNase H domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0328.
    HOGENOMiHOG000040465.
    KOiK03469.
    OMAiRKQVEIF.
    OrthoDBiEOG696BTR.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00042. RNase_H.
    InterProiIPR022892. RNaseH.
    IPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    [Graphical view]
    PfamiPF00075. RNase_H. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.
    PROSITEiPS50879. RNASE_H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A7Q5-1 [UniParc]FASTAAdd to Basket

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    MVSVSRTIWR VIAVLIAVIY VRLIVLQFDS ITGSLPEMLK QVEIFTDGSC    50
    LGNPGPGGYG AILRYRGREK TFSAGYTRTT NNRMELMAAI VALEALKEHC 100
    EVILSTDSQY VRQGITQWIH NWKKRGWKTA DKKPVKNVDL WQRLDAALGQ 150
    HQIKWEWVKG HAGHPENERC DELARAAAMN PTLEDTGYQV EV 192
    Length:192
    Mass (Da):21,738
    Last modified:January 23, 2007 - v1
    Checksum:i7C59C9837F87BE98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABI99694.1.
    RefSeqiYP_851409.1. NC_008563.1.

    Genome annotation databases

    EnsemblBacteriaiABI99694; ABI99694; APECO1_1776.
    GeneIDi4495816.
    KEGGiecv:APECO1_1776.
    PATRICi18211827. VBIEscCol127180_0221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000468 Genomic DNA. Translation: ABI99694.1 .
    RefSeqi YP_851409.1. NC_008563.1.

    3D structure databases

    ProteinModelPortali A1A7Q5.
    SMRi A1A7Q5. Positions 38-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405955.APECO1_1776.

    Chemistry

    BindingDBi A1A7Q5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI99694 ; ABI99694 ; APECO1_1776 .
    GeneIDi 4495816.
    KEGGi ecv:APECO1_1776.
    PATRICi 18211827. VBIEscCol127180_0221.

    Phylogenomic databases

    eggNOGi COG0328.
    HOGENOMi HOG000040465.
    KOi K03469.
    OMAi RKQVEIF.
    OrthoDBi EOG696BTR.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00042. RNase_H.
    InterProi IPR022892. RNaseH.
    IPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    [Graphical view ]
    Pfami PF00075. RNase_H. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    PROSITEi PS50879. RNASE_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
      Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
      J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: APEC O1Imported.

    Entry informationi

    Entry nameiA1A7Q5_ECOK1
    AccessioniPrimary (citable) accession number: A1A7Q5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3