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A1A7Q5

- A1A7Q5_ECOK1

UniProt

A1A7Q5 - A1A7Q5_ECOK1

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Protein
Ribonuclease H
Gene
rnhA, APECO1_1776
Organism
Escherichia coli O1:K1 / APEC
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotations

Cofactori

Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Magnesium 1 By similarityUniRule annotation
Metal bindingi47 – 471Magnesium 2 By similarityUniRule annotation
Metal bindingi85 – 851Magnesium 1 By similarityUniRule annotation
Metal bindingi107 – 1071Magnesium 1 By similarityUniRule annotation
Metal bindingi171 – 1711Magnesium 2 By similarityUniRule annotation

GO - Molecular functioni

  1. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotations, Hydrolase, Nuclease

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HUniRule annotation
Gene namesi
Name:rnhAUniRule annotationImported
ORF Names:APECO1_1776Imported
OrganismiEscherichia coli O1:K1 / APECImported
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008216: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi405955.APECO1_1776.

Structurei

3D structure databases

ProteinModelPortaliA1A7Q5.
SMRiA1A7Q5. Positions 38-192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 179142RNase H By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation
Contains 1 RNase H domain.UniRule annotation
Contains RNase H domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG0328.
HOGENOMiHOG000040465.
KOiK03469.
OMAiRKQVEIF.
OrthoDBiEOG696BTR.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00042. RNase_H.
InterProiIPR022892. RNaseH.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A7Q5-1 [UniParc]FASTAAdd to Basket

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MVSVSRTIWR VIAVLIAVIY VRLIVLQFDS ITGSLPEMLK QVEIFTDGSC    50
LGNPGPGGYG AILRYRGREK TFSAGYTRTT NNRMELMAAI VALEALKEHC 100
EVILSTDSQY VRQGITQWIH NWKKRGWKTA DKKPVKNVDL WQRLDAALGQ 150
HQIKWEWVKG HAGHPENERC DELARAAAMN PTLEDTGYQV EV 192
Length:192
Mass (Da):21,738
Last modified:January 23, 2007 - v1
Checksum:i7C59C9837F87BE98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABI99694.1.
RefSeqiYP_851409.1. NC_008563.1.

Genome annotation databases

EnsemblBacteriaiABI99694; ABI99694; APECO1_1776.
GeneIDi4495816.
KEGGiecv:APECO1_1776.
PATRICi18211827. VBIEscCol127180_0221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000468 Genomic DNA. Translation: ABI99694.1 .
RefSeqi YP_851409.1. NC_008563.1.

3D structure databases

ProteinModelPortali A1A7Q5.
SMRi A1A7Q5. Positions 38-192.
ModBasei Search...

Protein-protein interaction databases

STRINGi 405955.APECO1_1776.

Chemistry

BindingDBi A1A7Q5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI99694 ; ABI99694 ; APECO1_1776 .
GeneIDi 4495816.
KEGGi ecv:APECO1_1776.
PATRICi 18211827. VBIEscCol127180_0221.

Phylogenomic databases

eggNOGi COG0328.
HOGENOMi HOG000040465.
KOi K03469.
OMAi RKQVEIF.
OrthoDBi EOG696BTR.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00042. RNase_H.
InterProi IPR022892. RNaseH.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS50879. RNASE_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
    Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
    J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: APEC O1Imported.

Entry informationi

Entry nameiA1A7Q5_ECOK1
AccessioniPrimary (citable) accession number: A1A7Q5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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