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A1A7Q5 (A1A7Q5_ECOK1) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity. HAMAP-Rule MF_00042 SAAS SAAS002156

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00042 SAAS SAAS002156

Cofactor

Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding By similarity. HAMAP-Rule MF_00042 SAAS SAAS002156

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00042 SAAS SAAS002156

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00042 SAAS SAAS002156.

Sequence similarities

Belongs to the RNase H family. HAMAP-Rule MF_00042

Contains 1 RNase H domain. HAMAP-Rule MF_00042

Contains RNase H domain. SAAS SAAS022892

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain38 – 179142RNase H By similarity HAMAP-Rule MF_00042

Sites

Metal binding471Magnesium 1 By similarity HAMAP-Rule MF_00042
Metal binding471Magnesium 2 By similarity HAMAP-Rule MF_00042
Metal binding851Magnesium 1 By similarity HAMAP-Rule MF_00042
Metal binding1071Magnesium 1 By similarity HAMAP-Rule MF_00042
Metal binding1711Magnesium 2 By similarity HAMAP-Rule MF_00042

Sequences

Sequence LengthMass (Da)Tools
A1A7Q5 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 7C59C9837F87BE98

FASTA19221,738
        10         20         30         40         50         60 
MVSVSRTIWR VIAVLIAVIY VRLIVLQFDS ITGSLPEMLK QVEIFTDGSC LGNPGPGGYG 

        70         80         90        100        110        120 
AILRYRGREK TFSAGYTRTT NNRMELMAAI VALEALKEHC EVILSTDSQY VRQGITQWIH 

       130        140        150        160        170        180 
NWKKRGWKTA DKKPVKNVDL WQRLDAALGQ HQIKWEWVKG HAGHPENERC DELARAAAMN 

       190 
PTLEDTGYQV EV 

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References

[1]"The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes."
Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J., Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.
J. Bacteriol. 189:3228-3236(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APEC O1 EMBL ABI99694.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000468 Genomic DNA. Translation: ABI99694.1.
RefSeqYP_851409.1. NC_008563.1.

3D structure databases

ProteinModelPortalA1A7Q5.
SMRA1A7Q5. Positions 38-192.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405955.APECO1_1776.

Chemistry

BindingDBA1A7Q5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI99694; ABI99694; APECO1_1776.
GeneID4495816.
KEGGecv:APECO1_1776.
PATRIC18211827. VBIEscCol127180_0221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0328.
HOGENOMHOG000040465.
KOK03469.
OMAITSWIHN.
OrthoDBEOG696BTR.
ProtClustDBPRK00203.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00042. RNase_H.
InterProIPR022892. RNaseH.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
[Graphical view]
PfamPF00075. RNase_H. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
PROSITEPS50879. RNASE_H. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1A7Q5_ECOK1
AccessionPrimary (citable) accession number: A1A7Q5
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)