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Reviewed, UniProtKB/Swiss-Prot A1A5Z0 (G6PC3_DANRE)

Last modified February 10, 2009. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glucose-6-phosphatase 3
      Short name=G-6-Pase 3
      Short name=G6Pase 3
    EC=3.1.3.9
Gene names
Name: g6pc3
ORF Names: zgc:158425
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis By similarity.

Catalytic activity

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glucose-6-phosphatase family.

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Ontologies

Keywords
   Biological processGluconeogenesis
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionglucose-6-phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Glucose-6-phosphatase 3
PRO_0000334515

Regions

Topological domain1 – 2626Lumenal Potential
Transmembrane27 – 4721 Potential
Topological domain48 – 547Cytoplasmic Potential
Transmembrane55 – 7521 Potential
Topological domain76 – 11439Lumenal Potential
Transmembrane115 – 13218 Potential
Topological domain133 – 14311Cytoplasmic Potential
Transmembrane144 – 16421 Potential
Topological domain165 – 1695Lumenal Potential
Transmembrane170 – 18617 Potential
Topological domain187 – 1959Cytoplasmic Potential
Transmembrane196 – 21621 Potential
Topological domain217 – 30892Lumenal Potential
Transmembrane309 – 32921 Potential
Topological domain330 – 33910Cytoplasmic Potential

Sites

Active site1141Proton donor Potential
Active site1671Nucleophile By similarity
Binding site791Substrate Potential
Binding site1611Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
A1A5Z0-1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: A22AE6F35F354057

FASTA33938,003
        10         20         30         40         50         60 
MESLYRQGVW MAEALQQNSR SLEDLWLVAS HMGDPKAAVL LVFPVVFYIH RRTGIAVLWV 

        70         80         90        100        110        120 
AALSEWLNLV FKWILFGERP YWWIGQSGLF SEKPPEVQQF QSTCESGPGS PSGHAMVTSA 

       130        140        150        160        170        180 
VWWVIISSLA SFSQAYTGSK ILSAVLYLLY AVFLGCVGLS RIFILAHFPH QVVAGLLTGV 

       190        200        210        220        230        240 
LLGVFLKRSV PERRPLLFFF RFSMALLGAA LIFHAVLEKT GIDLSWSISL AKRWCSRSEW 

       250        260        270        280        290        300 
VRMDTAPFSS LNRDAGVLLG LGLAQYWKPG GWTLPRAPRT LCLALSSLAL HYISRFPLPT 

       310        320        330 
VPPLLFYSLF FLKYSIVPQV VMVLVPGFVH LLTAKPKRE

« Hide

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References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

BC128866 mRNA. Translation: AAI28867.1.
IPIIPI00638981.
RefSeqNP_001073535.1.
UniGeneDr.117104

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSDARG00000020371. Danio rerio. [Contig view]
GeneID790919.
KEGGdre:790919.

Organism-specific databases

ZFINZDB-GENE-061215-19. zgc:158425.

Phylogenomic databases

HOVERGENA1A5Z0.

Gene expression databases

BgeeA1A5Z0.

Family and domain databases

InterProIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameG6PC3_DANRE
AccessionPrimary (citable) accession number: A1A5Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: February 10, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents