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A1A5Z0 (G6PC3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphatase 3

Short name=G-6-Pase 3
Short name=G6Pase 3
EC=3.1.3.9
Gene names
Name:g6pc3
ORF Names:zgc:158425
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis By similarity.

Catalytic activity

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glucose-6-phosphatase family.

Ontologies

Keywords
   Biological processGluconeogenesis
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucose-6-phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Glucose-6-phosphatase 3
PRO_0000334515

Regions

Topological domain1 – 2626Lumenal Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 547Cytoplasmic Potential
Transmembrane55 – 7521Helical; Potential
Topological domain76 – 11439Lumenal Potential
Transmembrane115 – 13218Helical; Potential
Topological domain133 – 14311Cytoplasmic Potential
Transmembrane144 – 16421Helical; Potential
Topological domain165 – 1695Lumenal Potential
Transmembrane170 – 18617Helical; Potential
Topological domain187 – 1959Cytoplasmic Potential
Transmembrane196 – 21621Helical; Potential
Topological domain217 – 30892Lumenal Potential
Transmembrane309 – 32921Helical; Potential
Topological domain330 – 33910Cytoplasmic Potential

Sites

Active site1141Proton donor Potential
Active site1671Nucleophile By similarity
Binding site791Substrate Potential
Binding site1611Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
A1A5Z0 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: A22AE6F35F354057

FASTA33938,003
        10         20         30         40         50         60 
MESLYRQGVW MAEALQQNSR SLEDLWLVAS HMGDPKAAVL LVFPVVFYIH RRTGIAVLWV 

        70         80         90        100        110        120 
AALSEWLNLV FKWILFGERP YWWIGQSGLF SEKPPEVQQF QSTCESGPGS PSGHAMVTSA 

       130        140        150        160        170        180 
VWWVIISSLA SFSQAYTGSK ILSAVLYLLY AVFLGCVGLS RIFILAHFPH QVVAGLLTGV 

       190        200        210        220        230        240 
LLGVFLKRSV PERRPLLFFF RFSMALLGAA LIFHAVLEKT GIDLSWSISL AKRWCSRSEW 

       250        260        270        280        290        300 
VRMDTAPFSS LNRDAGVLLG LGLAQYWKPG GWTLPRAPRT LCLALSSLAL HYISRFPLPT 

       310        320        330 
VPPLLFYSLF FLKYSIVPQV VMVLVPGFVH LLTAKPKRE 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC128866 mRNA. Translation: AAI28867.1.
RefSeqNP_001073535.1. NM_001080066.1.
UniGeneDr.117104.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000027964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID790919.
KEGGdre:790919.

Organism-specific databases

CTD92579.
ZFINZDB-GENE-061215-19. g6pc3.

Phylogenomic databases

eggNOGNOG82628.
HOGENOMHOG000264239.
HOVERGENHBG003560.
InParanoidA1A5Z0.
KOK01084.
PhylomeDBA1A5Z0.

Enzyme and pathway databases

UniPathwayUPA00138.

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 1 hit.
ProtoNetSearch...

Other

NextBio20930406.

Entry information

Entry nameG6PC3_DANRE
AccessionPrimary (citable) accession number: A1A5Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways