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A1A5Z0

- G6PC3_DANRE

UniProt

A1A5Z0 - G6PC3_DANRE

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Protein

Glucose-6-phosphatase 3

Gene

g6pc3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791SubstrateSequence Analysis
Active sitei114 – 1141Proton donorSequence Analysis
Binding sitei161 – 1611SubstrateSequence Analysis
Active sitei167 – 1671NucleophileBy similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Gene namesi
Name:g6pc3
ORF Names:zgc:158425
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061215-19. g6pc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626LumenalSequence AnalysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 547CytoplasmicSequence Analysis
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 11439LumenalSequence AnalysisAdd
BLAST
Transmembranei115 – 13218HelicalSequence AnalysisAdd
BLAST
Topological domaini133 – 14311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Topological domaini165 – 1695LumenalSequence Analysis
Transmembranei170 – 18617HelicalSequence AnalysisAdd
BLAST
Topological domaini187 – 1959CytoplasmicSequence Analysis
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Topological domaini217 – 30892LumenalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Topological domaini330 – 33910CytoplasmicSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Glucose-6-phosphatase 3PRO_0000334515Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000027964.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiA1A5Z0.
KOiK01084.
PhylomeDBiA1A5Z0.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

A1A5Z0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESLYRQGVW MAEALQQNSR SLEDLWLVAS HMGDPKAAVL LVFPVVFYIH
60 70 80 90 100
RRTGIAVLWV AALSEWLNLV FKWILFGERP YWWIGQSGLF SEKPPEVQQF
110 120 130 140 150
QSTCESGPGS PSGHAMVTSA VWWVIISSLA SFSQAYTGSK ILSAVLYLLY
160 170 180 190 200
AVFLGCVGLS RIFILAHFPH QVVAGLLTGV LLGVFLKRSV PERRPLLFFF
210 220 230 240 250
RFSMALLGAA LIFHAVLEKT GIDLSWSISL AKRWCSRSEW VRMDTAPFSS
260 270 280 290 300
LNRDAGVLLG LGLAQYWKPG GWTLPRAPRT LCLALSSLAL HYISRFPLPT
310 320 330
VPPLLFYSLF FLKYSIVPQV VMVLVPGFVH LLTAKPKRE
Length:339
Mass (Da):38,003
Last modified:January 23, 2007 - v1
Checksum:iA22AE6F35F354057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128866 mRNA. Translation: AAI28867.1.
RefSeqiNP_001073535.1. NM_001080066.1.
UniGeneiDr.117104.

Genome annotation databases

GeneIDi790919.
KEGGidre:790919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128866 mRNA. Translation: AAI28867.1 .
RefSeqi NP_001073535.1. NM_001080066.1.
UniGenei Dr.117104.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000027964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 790919.
KEGGi dre:790919.

Organism-specific databases

CTDi 92579.
ZFINi ZDB-GENE-061215-19. g6pc3.

Phylogenomic databases

eggNOGi NOG82628.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
InParanoidi A1A5Z0.
KOi K01084.
PhylomeDBi A1A5Z0.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Miscellaneous databases

NextBioi 20930406.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiG6PC3_DANRE
AccessioniPrimary (citable) accession number: A1A5Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3