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A1A5Z0

- G6PC3_DANRE

UniProt

A1A5Z0 - G6PC3_DANRE

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Protein

Glucose-6-phosphatase 3

Gene
g6pc3, zgc:158425
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis By similarity.

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate Reviewed prediction
Active sitei114 – 1141Proton donor Reviewed prediction
Binding sitei161 – 1611Substrate Reviewed prediction
Active sitei167 – 1671Nucleophile By similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Gene namesi
Name:g6pc3
ORF Names:zgc:158425
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061215-19. g6pc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Lumenal Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Reviewed predictionAdd
BLAST
Topological domaini48 – 547Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Reviewed predictionAdd
BLAST
Topological domaini76 – 11439Lumenal Reviewed predictionAdd
BLAST
Transmembranei115 – 13218Helical; Reviewed predictionAdd
BLAST
Topological domaini133 – 14311Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei144 – 16421Helical; Reviewed predictionAdd
BLAST
Topological domaini165 – 1695Lumenal Reviewed prediction
Transmembranei170 – 18617Helical; Reviewed predictionAdd
BLAST
Topological domaini187 – 1959Cytoplasmic Reviewed prediction
Transmembranei196 – 21621Helical; Reviewed predictionAdd
BLAST
Topological domaini217 – 30892Lumenal Reviewed predictionAdd
BLAST
Transmembranei309 – 32921Helical; Reviewed predictionAdd
BLAST
Topological domaini330 – 33910Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Glucose-6-phosphatase 3PRO_0000334515Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000027964.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
InParanoidiA1A5Z0.
KOiK01084.
PhylomeDBiA1A5Z0.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

A1A5Z0-1 [UniParc]FASTAAdd to Basket

« Hide

MESLYRQGVW MAEALQQNSR SLEDLWLVAS HMGDPKAAVL LVFPVVFYIH    50
RRTGIAVLWV AALSEWLNLV FKWILFGERP YWWIGQSGLF SEKPPEVQQF 100
QSTCESGPGS PSGHAMVTSA VWWVIISSLA SFSQAYTGSK ILSAVLYLLY 150
AVFLGCVGLS RIFILAHFPH QVVAGLLTGV LLGVFLKRSV PERRPLLFFF 200
RFSMALLGAA LIFHAVLEKT GIDLSWSISL AKRWCSRSEW VRMDTAPFSS 250
LNRDAGVLLG LGLAQYWKPG GWTLPRAPRT LCLALSSLAL HYISRFPLPT 300
VPPLLFYSLF FLKYSIVPQV VMVLVPGFVH LLTAKPKRE 339
Length:339
Mass (Da):38,003
Last modified:January 23, 2007 - v1
Checksum:iA22AE6F35F354057
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128866 mRNA. Translation: AAI28867.1.
RefSeqiNP_001073535.1. NM_001080066.1.
UniGeneiDr.117104.

Genome annotation databases

GeneIDi790919.
KEGGidre:790919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128866 mRNA. Translation: AAI28867.1 .
RefSeqi NP_001073535.1. NM_001080066.1.
UniGenei Dr.117104.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000027964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 790919.
KEGGi dre:790919.

Organism-specific databases

CTDi 92579.
ZFINi ZDB-GENE-061215-19. g6pc3.

Phylogenomic databases

eggNOGi NOG82628.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
InParanoidi A1A5Z0.
KOi K01084.
PhylomeDBi A1A5Z0.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Miscellaneous databases

NextBioi 20930406.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiG6PC3_DANRE
AccessioniPrimary (citable) accession number: A1A5Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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