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A1A5Y0

- NELL2_DANRE

UniProt

A1A5Y0 - NELL2_DANRE

Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL2
    Alternative name(s):
    NEL-like protein 2
    Gene namesi
    Name:nell2
    ORF Names:zgc:158375
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-030131-7972. nell2a.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 811793Protein kinase C-binding protein NELL2PRO_0000354683Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi399 ↔ 411By similarity
    Disulfide bondi405 ↔ 420By similarity
    Disulfide bondi422 ↔ 436By similarity
    Disulfide bondi442 ↔ 455By similarity
    Disulfide bondi449 ↔ 464By similarity
    Disulfide bondi466 ↔ 478By similarity
    Disulfide bondi484 ↔ 497By similarity
    Disulfide bondi491 ↔ 506By similarity
    Disulfide bondi508 ↔ 519By similarity
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi523 ↔ 533By similarity
    Disulfide bondi527 ↔ 539By similarity
    Disulfide bondi541 ↔ 550By similarity
    Disulfide bondi557 ↔ 570By similarity
    Disulfide bondi564 ↔ 579By similarity
    Disulfide bondi604 ↔ 617By similarity
    Disulfide bondi611 ↔ 626By similarity
    Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi628 ↔ 634By similarity
    Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA1A5Y0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 225172Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini269 – 32860VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini395 – 43743EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini438 – 47942EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini480 – 52041EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini521 – 55131EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini553 – 59240EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini600 – 63536EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini636 – 69156VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini696 – 75459VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG004805.
    PhylomeDBiA1A5Y0.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07645. EGF_CA. 4 hits.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 3 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1A5Y0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFLQLFVGL LCGAAVSAFG VDPAVRIGVF QEFSPGQGFS GVTQVKGFRD    50
    DTRAFMFQGS SRSVRVPDAA AGHMLQKLRG KTEFSIALTL KQDKLNSGVI 100
    LSIHHGEHRL LELESSGQKS EVRLHFRTGL QQTHTEIFPF TLADEQWHRV 150
    SVSISAAHLT LYVDCNRIYE RVVPVPLMEI PEDSSFWVGQ RNSAHGLFKG 200
    IMQDLQILVM PQGFITQCPD LNRTCPTCND FHGLVQKIME LQDILAKTSS 250
    KLSLAEEKMS GLDSCYCERT CRVKDQIYRE EQSWTDGCKN CTCSNGTVRC 300
    EKILCPPLDC PDGTTPAYVT GTCCKECQPM CLFSEQTLVE GQSCAVHHPS 350
    GLCQLFQCRD RTMHRVPGAE DCPALSCAES DQITLTDRCC RVCRGHDFCA 400
    EENICSENSD CVNLDAGASC GCKNGFRPLR LDSAYCEDID ECAEGRHYCR 450
    ENTECVNTAG SFMCVCHTGF IRIDDYSCTE HDECASGQHD CDENALCFNT 500
    VGGHSCSCKP GYSGNGTVCR ALCDGRCLNG GSCASPNVCV CVQGFSGQNC 550
    ETDIDECSEG LVQCAAHATC VNLPGWYHCE CRDGYHDNEV FSANGESCRD 600
    IDECRTGRST CANDTVCFNL DGGFDCRCPH GHNCSGDCIH NSRVRHNAQI 650
    WVLDTDHCSV CSCQEGQVKC RRMVCDCENP TVDVLCCPEC DPRLTSQCLH 700
    QNGLLTYSSG DTWIDSCQRC QCLQGEVDCW PLSCPPVDCD FTLVPEGECC 750
    PRCVSDPCQA HAVRSDISKT CIDEHGITRF SGSAWVKHGT HCTLCQCKNG 800
    HVCCSVDPMC L 811
    Length:811
    Mass (Da):89,142
    Last modified:January 23, 2007 - v1
    Checksum:i9D588B3B1574CEC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128854 mRNA. Translation: AAI28855.1.
    RefSeqiNP_001073544.1. NM_001080075.1.
    UniGeneiDr.107080.
    Dr.124568.

    Genome annotation databases

    GeneIDi790930.
    KEGGidre:790930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128854 mRNA. Translation: AAI28855.1 .
    RefSeqi NP_001073544.1. NM_001080075.1.
    UniGenei Dr.107080.
    Dr.124568.

    3D structure databases

    ProteinModelPortali A1A5Y0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 790930.
    KEGGi dre:790930.

    Organism-specific databases

    CTDi 790930.
    ZFINi ZDB-GENE-030131-7972. nell2a.

    Phylogenomic databases

    HOVERGENi HBG004805.
    PhylomeDBi A1A5Y0.

    Miscellaneous databases

    NextBioi 20930414.
    PROi A1A5Y0.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 4 hits.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 3 hits.
    SM00179. EGF_CA. 3 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiNELL2_DANRE
    AccessioniPrimary (citable) accession number: A1A5Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3