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A1A5Y0 (NELL2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene names
Name:nell2
ORF Names:zgc:158375
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 6 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 3 VWFC domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 811793Protein kinase C-binding protein NELL2
PRO_0000354683

Regions

Domain54 – 225172Laminin G-like
Domain269 – 32860VWFC 1
Domain395 – 43743EGF-like 1
Domain438 – 47942EGF-like 2; calcium-binding Potential
Domain480 – 52041EGF-like 3; calcium-binding Potential
Domain521 – 55131EGF-like 4
Domain553 – 59240EGF-like 5; calcium-binding Potential
Domain600 – 63536EGF-like 6; calcium-binding Potential
Domain636 – 69156VWFC 2
Domain696 – 75459VWFC 3

Amino acid modifications

Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation6131N-linked (GlcNAc...) Potential
Glycosylation6331N-linked (GlcNAc...) Potential
Disulfide bond399 ↔ 411 By similarity
Disulfide bond405 ↔ 420 By similarity
Disulfide bond422 ↔ 436 By similarity
Disulfide bond442 ↔ 455 By similarity
Disulfide bond449 ↔ 464 By similarity
Disulfide bond466 ↔ 478 By similarity
Disulfide bond484 ↔ 497 By similarity
Disulfide bond491 ↔ 506 By similarity
Disulfide bond508 ↔ 519 By similarity
Disulfide bond523 ↔ 533 By similarity
Disulfide bond527 ↔ 539 By similarity
Disulfide bond541 ↔ 550 By similarity
Disulfide bond557 ↔ 570 By similarity
Disulfide bond564 ↔ 579 By similarity
Disulfide bond604 ↔ 617 By similarity
Disulfide bond611 ↔ 626 By similarity
Disulfide bond628 ↔ 634 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1A5Y0 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 9D588B3B1574CEC7

FASTA81189,142
        10         20         30         40         50         60 
MAFLQLFVGL LCGAAVSAFG VDPAVRIGVF QEFSPGQGFS GVTQVKGFRD DTRAFMFQGS 

        70         80         90        100        110        120 
SRSVRVPDAA AGHMLQKLRG KTEFSIALTL KQDKLNSGVI LSIHHGEHRL LELESSGQKS 

       130        140        150        160        170        180 
EVRLHFRTGL QQTHTEIFPF TLADEQWHRV SVSISAAHLT LYVDCNRIYE RVVPVPLMEI 

       190        200        210        220        230        240 
PEDSSFWVGQ RNSAHGLFKG IMQDLQILVM PQGFITQCPD LNRTCPTCND FHGLVQKIME 

       250        260        270        280        290        300 
LQDILAKTSS KLSLAEEKMS GLDSCYCERT CRVKDQIYRE EQSWTDGCKN CTCSNGTVRC 

       310        320        330        340        350        360 
EKILCPPLDC PDGTTPAYVT GTCCKECQPM CLFSEQTLVE GQSCAVHHPS GLCQLFQCRD 

       370        380        390        400        410        420 
RTMHRVPGAE DCPALSCAES DQITLTDRCC RVCRGHDFCA EENICSENSD CVNLDAGASC 

       430        440        450        460        470        480 
GCKNGFRPLR LDSAYCEDID ECAEGRHYCR ENTECVNTAG SFMCVCHTGF IRIDDYSCTE 

       490        500        510        520        530        540 
HDECASGQHD CDENALCFNT VGGHSCSCKP GYSGNGTVCR ALCDGRCLNG GSCASPNVCV 

       550        560        570        580        590        600 
CVQGFSGQNC ETDIDECSEG LVQCAAHATC VNLPGWYHCE CRDGYHDNEV FSANGESCRD 

       610        620        630        640        650        660 
IDECRTGRST CANDTVCFNL DGGFDCRCPH GHNCSGDCIH NSRVRHNAQI WVLDTDHCSV 

       670        680        690        700        710        720 
CSCQEGQVKC RRMVCDCENP TVDVLCCPEC DPRLTSQCLH QNGLLTYSSG DTWIDSCQRC 

       730        740        750        760        770        780 
QCLQGEVDCW PLSCPPVDCD FTLVPEGECC PRCVSDPCQA HAVRSDISKT CIDEHGITRF 

       790        800        810 
SGSAWVKHGT HCTLCQCKNG HVCCSVDPMC L

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC128854 mRNA. Translation: AAI28855.1.
IPIIPI00829092.
RefSeqNP_001073544.1. NM_001080075.1.
UniGeneDr.107080.
Dr.124568.

3D structure databases

ProteinModelPortalA1A5Y0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID790930.
KEGGdre:790930.

Organism-specific databases

CTD790930.
ZFINZDB-GENE-030131-7972. nell2a.

Phylogenomic databases

HOVERGENHBG004805.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF07645. EGF_CA. 4 hits.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 3 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20930414.

Entry information

Entry nameNELL2_DANRE
AccessionPrimary (citable) accession number: A1A5Y0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 23, 2007
Last modified: March 6, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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