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A1A5Y0

- NELL2_DANRE

UniProt

A1A5Y0 - NELL2_DANRE

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Protein
Protein kinase C-binding protein NELL2
Gene
nell2, zgc:158375
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
ORF Names:zgc:158375
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-7972. nell2a.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 811793Protein kinase C-binding protein NELL2
PRO_0000354683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi399 ↔ 411 By similarity
Disulfide bondi405 ↔ 420 By similarity
Disulfide bondi422 ↔ 436 By similarity
Disulfide bondi442 ↔ 455 By similarity
Disulfide bondi449 ↔ 464 By similarity
Disulfide bondi466 ↔ 478 By similarity
Disulfide bondi484 ↔ 497 By similarity
Disulfide bondi491 ↔ 506 By similarity
Disulfide bondi508 ↔ 519 By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi523 ↔ 533 By similarity
Disulfide bondi527 ↔ 539 By similarity
Disulfide bondi541 ↔ 550 By similarity
Disulfide bondi557 ↔ 570 By similarity
Disulfide bondi564 ↔ 579 By similarity
Disulfide bondi604 ↔ 617 By similarity
Disulfide bondi611 ↔ 626 By similarity
Glycosylationi613 – 6131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi628 ↔ 634 By similarity
Glycosylationi633 – 6331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1A5Y0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 225172Laminin G-like
Add
BLAST
Domaini269 – 32860VWFC 1
Add
BLAST
Domaini395 – 43743EGF-like 1
Add
BLAST
Domaini438 – 47942EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini480 – 52041EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini521 – 55131EGF-like 4
Add
BLAST
Domaini553 – 59240EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini600 – 63536EGF-like 6; calcium-binding Reviewed prediction
Add
BLAST
Domaini636 – 69156VWFC 2
Add
BLAST
Domaini696 – 75459VWFC 3
Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004805.
PhylomeDBiA1A5Y0.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1A5Y0-1 [UniParc]FASTAAdd to Basket

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MAFLQLFVGL LCGAAVSAFG VDPAVRIGVF QEFSPGQGFS GVTQVKGFRD    50
DTRAFMFQGS SRSVRVPDAA AGHMLQKLRG KTEFSIALTL KQDKLNSGVI 100
LSIHHGEHRL LELESSGQKS EVRLHFRTGL QQTHTEIFPF TLADEQWHRV 150
SVSISAAHLT LYVDCNRIYE RVVPVPLMEI PEDSSFWVGQ RNSAHGLFKG 200
IMQDLQILVM PQGFITQCPD LNRTCPTCND FHGLVQKIME LQDILAKTSS 250
KLSLAEEKMS GLDSCYCERT CRVKDQIYRE EQSWTDGCKN CTCSNGTVRC 300
EKILCPPLDC PDGTTPAYVT GTCCKECQPM CLFSEQTLVE GQSCAVHHPS 350
GLCQLFQCRD RTMHRVPGAE DCPALSCAES DQITLTDRCC RVCRGHDFCA 400
EENICSENSD CVNLDAGASC GCKNGFRPLR LDSAYCEDID ECAEGRHYCR 450
ENTECVNTAG SFMCVCHTGF IRIDDYSCTE HDECASGQHD CDENALCFNT 500
VGGHSCSCKP GYSGNGTVCR ALCDGRCLNG GSCASPNVCV CVQGFSGQNC 550
ETDIDECSEG LVQCAAHATC VNLPGWYHCE CRDGYHDNEV FSANGESCRD 600
IDECRTGRST CANDTVCFNL DGGFDCRCPH GHNCSGDCIH NSRVRHNAQI 650
WVLDTDHCSV CSCQEGQVKC RRMVCDCENP TVDVLCCPEC DPRLTSQCLH 700
QNGLLTYSSG DTWIDSCQRC QCLQGEVDCW PLSCPPVDCD FTLVPEGECC 750
PRCVSDPCQA HAVRSDISKT CIDEHGITRF SGSAWVKHGT HCTLCQCKNG 800
HVCCSVDPMC L 811
Length:811
Mass (Da):89,142
Last modified:January 23, 2007 - v1
Checksum:i9D588B3B1574CEC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128854 mRNA. Translation: AAI28855.1.
RefSeqiNP_001073544.1. NM_001080075.1.
UniGeneiDr.107080.
Dr.124568.

Genome annotation databases

GeneIDi790930.
KEGGidre:790930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128854 mRNA. Translation: AAI28855.1 .
RefSeqi NP_001073544.1. NM_001080075.1.
UniGenei Dr.107080.
Dr.124568.

3D structure databases

ProteinModelPortali A1A5Y0.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 790930.
KEGGi dre:790930.

Organism-specific databases

CTDi 790930.
ZFINi ZDB-GENE-030131-7972. nell2a.

Phylogenomic databases

HOVERGENi HBG004805.
PhylomeDBi A1A5Y0.

Miscellaneous databases

NextBioi 20930414.
PROi A1A5Y0.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 4 hits.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 3 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNELL2_DANRE
AccessioniPrimary (citable) accession number: A1A5Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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