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A1A5Y0

- NELL2_DANRE

UniProt

A1A5Y0 - NELL2_DANRE

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Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
ORF Names:zgc:158375
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-7972. nell2a.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 811793Protein kinase C-binding protein NELL2PRO_0000354683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi399 ↔ 411By similarity
Disulfide bondi405 ↔ 420By similarity
Disulfide bondi422 ↔ 436By similarity
Disulfide bondi442 ↔ 455By similarity
Disulfide bondi449 ↔ 464By similarity
Disulfide bondi466 ↔ 478By similarity
Disulfide bondi484 ↔ 497By similarity
Disulfide bondi491 ↔ 506By similarity
Disulfide bondi508 ↔ 519By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi523 ↔ 533By similarity
Disulfide bondi527 ↔ 539By similarity
Disulfide bondi541 ↔ 550By similarity
Disulfide bondi557 ↔ 570By similarity
Disulfide bondi564 ↔ 579By similarity
Disulfide bondi604 ↔ 617By similarity
Disulfide bondi611 ↔ 626By similarity
Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi628 ↔ 634By similarity
Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1A5Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 225172Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini269 – 32860VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini395 – 43743EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini438 – 47942EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini480 – 52041EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini521 – 55131EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini553 – 59240EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini600 – 63536EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini636 – 69156VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini696 – 75459VWFC 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004805.
InParanoidiA1A5Y0.
PhylomeDBiA1A5Y0.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1A5Y0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFLQLFVGL LCGAAVSAFG VDPAVRIGVF QEFSPGQGFS GVTQVKGFRD
60 70 80 90 100
DTRAFMFQGS SRSVRVPDAA AGHMLQKLRG KTEFSIALTL KQDKLNSGVI
110 120 130 140 150
LSIHHGEHRL LELESSGQKS EVRLHFRTGL QQTHTEIFPF TLADEQWHRV
160 170 180 190 200
SVSISAAHLT LYVDCNRIYE RVVPVPLMEI PEDSSFWVGQ RNSAHGLFKG
210 220 230 240 250
IMQDLQILVM PQGFITQCPD LNRTCPTCND FHGLVQKIME LQDILAKTSS
260 270 280 290 300
KLSLAEEKMS GLDSCYCERT CRVKDQIYRE EQSWTDGCKN CTCSNGTVRC
310 320 330 340 350
EKILCPPLDC PDGTTPAYVT GTCCKECQPM CLFSEQTLVE GQSCAVHHPS
360 370 380 390 400
GLCQLFQCRD RTMHRVPGAE DCPALSCAES DQITLTDRCC RVCRGHDFCA
410 420 430 440 450
EENICSENSD CVNLDAGASC GCKNGFRPLR LDSAYCEDID ECAEGRHYCR
460 470 480 490 500
ENTECVNTAG SFMCVCHTGF IRIDDYSCTE HDECASGQHD CDENALCFNT
510 520 530 540 550
VGGHSCSCKP GYSGNGTVCR ALCDGRCLNG GSCASPNVCV CVQGFSGQNC
560 570 580 590 600
ETDIDECSEG LVQCAAHATC VNLPGWYHCE CRDGYHDNEV FSANGESCRD
610 620 630 640 650
IDECRTGRST CANDTVCFNL DGGFDCRCPH GHNCSGDCIH NSRVRHNAQI
660 670 680 690 700
WVLDTDHCSV CSCQEGQVKC RRMVCDCENP TVDVLCCPEC DPRLTSQCLH
710 720 730 740 750
QNGLLTYSSG DTWIDSCQRC QCLQGEVDCW PLSCPPVDCD FTLVPEGECC
760 770 780 790 800
PRCVSDPCQA HAVRSDISKT CIDEHGITRF SGSAWVKHGT HCTLCQCKNG
810
HVCCSVDPMC L
Length:811
Mass (Da):89,142
Last modified:January 23, 2007 - v1
Checksum:i9D588B3B1574CEC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128854 mRNA. Translation: AAI28855.1.
RefSeqiNP_001073544.1. NM_001080075.1.
UniGeneiDr.107080.
Dr.124568.

Genome annotation databases

GeneIDi790930.
KEGGidre:790930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128854 mRNA. Translation: AAI28855.1 .
RefSeqi NP_001073544.1. NM_001080075.1.
UniGenei Dr.107080.
Dr.124568.

3D structure databases

ProteinModelPortali A1A5Y0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 790930.
KEGGi dre:790930.

Organism-specific databases

CTDi 790930.
ZFINi ZDB-GENE-030131-7972. nell2a.

Phylogenomic databases

HOVERGENi HBG004805.
InParanoidi A1A5Y0.
PhylomeDBi A1A5Y0.

Miscellaneous databases

NextBioi 20930414.
PROi A1A5Y0.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 4 hits.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 3 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNELL2_DANRE
AccessioniPrimary (citable) accession number: A1A5Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3