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A1A5X2 (FBXL7_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
Gene names
Name:fbxl7
ORF Names:zgc:158346
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: Localizes to the centrosome during spindle formation By similarity.

Sequence similarities

Belongs to the FBXL7 family.

Contains 1 F-box domain.

Contains 11 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Cytoskeleton
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489F-box/LRR-repeat protein 7
PRO_0000417991

Regions

Domain109 – 15547F-box
Repeat168 – 19326LRR 1
Repeat194 – 21926LRR 2
Repeat220 – 24526LRR 3
Repeat251 – 27929LRR 4
Repeat280 – 30526LRR 5
Repeat306 – 33126LRR 6
Repeat332 – 35726LRR 7
Repeat358 – 38326LRR 8
Repeat384 – 40926LRR 9
Repeat410 – 43526LRR 10
Repeat436 – 46126LRR 11

Sequences

Sequence LengthMass (Da)Tools
A1A5X2 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 4C611A29877AB9D5

FASTA48954,220
        10         20         30         40         50         60 
MGANNGKQSG SEGKGSSSIS SDLSSSTDQT STKAPKNAAT SEDSDLSMRT VSTPSPALIL 

        70         80         90        100        110        120 
PPRSSSAVLN GSSTSSSTFG TETIAMVHMP PTSLTHPQRC LRQPRDQQGA PVDILPDHAF 

       130        140        150        160        170        180 
LQIFTHLPTN QLCRCARVCR RWYNLAWDPR LWRTIRLTGD VLHVDRALRV LTRRLCQDTP 

       190        200        210        220        230        240 
NVCLTVETVM VSGCRRLTDR GLYTVAQSCP ELRRLEVAGC YNVSNEAVFE VVSRCPNLEH 

       250        260        270        280        290        300 
LDVSGCSKVT CISLTRDVSV KLSPLHGQQI SIRFLDMTDC FALEDEGLHT IAAHCTQLTH 

       310        320        330        340        350        360 
LYLRRCVRLT DEGLRFLVIY CPGVRELSVS DCRFISDFGL REIAKLEGRL RYLSIAHCSR 

       370        380        390        400        410        420 
ITDVGVRYVA KYCSRLRYLN ARGCEGLTDH GIEHLAKSCL KLKSLDIGKC PLVSDAGLEQ 

       430        440        450        460        470        480 
LALNSFNLKR LSLKSCESIT GRGLQVVAAN CFDLQLLNVQ DCDVSLEALR FVKRHCKRCI 


IEHTNPAFF 

« Hide

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR450710 Genomic DNA. No translation available.
BC128845 mRNA. Translation: AAI28846.1.
BC129207 mRNA. Translation: AAI29208.1.
RefSeqNP_001073511.1. NM_001080042.1.
UniGeneDr.85307.

3D structure databases

ProteinModelPortalA1A5X2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000084255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000089822; ENSDARP00000084255; ENSDARG00000062251.
GeneID569430.
KEGGdre:569430.

Organism-specific databases

ZFINZDB-GENE-061215-122. zgc:158346.

Phylogenomic databases

eggNOGNOG259371.
GeneTreeENSGT00750000117590.
HOGENOMHOG000116328.
HOVERGENHBG051591.
InParanoidA1A5X2.
KOK10273.
OMALMLETVI.
OrthoDBEOG75MVWQ.
PhylomeDBA1A5X2.
TreeFamTF313434.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeA1A5X2.

Family and domain databases

InterProIPR001810. F-box_dom.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20889672.
PROA1A5X2.

Entry information

Entry nameFBXL7_DANRE
AccessionPrimary (citable) accession number: A1A5X2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways