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Protein

F-box/LRR-repeat protein 7

Gene

fbxl7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
Gene namesi
Name:fbxl7
ORF Names:zgc:158346
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-061215-122. fbxl7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004179911 – 489F-box/LRR-repeat protein 7Add BLAST489

Proteomic databases

PaxDbiA1A5X2.
PeptideAtlasiA1A5X2.
PRIDEiA1A5X2.

Expressioni

Gene expression databases

BgeeiENSDARG00000062251.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000084255.

Structurei

3D structure databases

ProteinModelPortaliA1A5X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 155F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati168 – 193LRR 1Add BLAST26
Repeati194 – 219LRR 2Add BLAST26
Repeati220 – 245LRR 3Add BLAST26
Repeati251 – 279LRR 4Add BLAST29
Repeati280 – 305LRR 5Add BLAST26
Repeati306 – 331LRR 6Add BLAST26
Repeati332 – 357LRR 7Add BLAST26
Repeati358 – 383LRR 8Add BLAST26
Repeati384 – 409LRR 9Add BLAST26
Repeati410 – 435LRR 10Add BLAST26
Repeati436 – 461LRR 11Add BLAST26

Sequence similaritiesi

Belongs to the FBXL7 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiA1A5X2.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG091G06QE.
PhylomeDBiA1A5X2.
TreeFamiTF313434.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 4 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 10 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGANNGKQSG SEGKGSSSIS SDLSSSTDQT STKAPKNAAT SEDSDLSMRT
60 70 80 90 100
VSTPSPALIL PPRSSSAVLN GSSTSSSTFG TETIAMVHMP PTSLTHPQRC
110 120 130 140 150
LRQPRDQQGA PVDILPDHAF LQIFTHLPTN QLCRCARVCR RWYNLAWDPR
160 170 180 190 200
LWRTIRLTGD VLHVDRALRV LTRRLCQDTP NVCLTVETVM VSGCRRLTDR
210 220 230 240 250
GLYTVAQSCP ELRRLEVAGC YNVSNEAVFE VVSRCPNLEH LDVSGCSKVT
260 270 280 290 300
CISLTRDVSV KLSPLHGQQI SIRFLDMTDC FALEDEGLHT IAAHCTQLTH
310 320 330 340 350
LYLRRCVRLT DEGLRFLVIY CPGVRELSVS DCRFISDFGL REIAKLEGRL
360 370 380 390 400
RYLSIAHCSR ITDVGVRYVA KYCSRLRYLN ARGCEGLTDH GIEHLAKSCL
410 420 430 440 450
KLKSLDIGKC PLVSDAGLEQ LALNSFNLKR LSLKSCESIT GRGLQVVAAN
460 470 480
CFDLQLLNVQ DCDVSLEALR FVKRHCKRCI IEHTNPAFF
Length:489
Mass (Da):54,220
Last modified:January 23, 2007 - v1
Checksum:i4C611A29877AB9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450710 Genomic DNA. No translation available.
BC128845 mRNA. Translation: AAI28846.1.
BC129207 mRNA. Translation: AAI29208.1.
RefSeqiNP_001073511.1. NM_001080042.1.
UniGeneiDr.85307.

Genome annotation databases

EnsembliENSDART00000089822; ENSDARP00000084255; ENSDARG00000062251.
GeneIDi569430.
KEGGidre:569430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450710 Genomic DNA. No translation available.
BC128845 mRNA. Translation: AAI28846.1.
BC129207 mRNA. Translation: AAI29208.1.
RefSeqiNP_001073511.1. NM_001080042.1.
UniGeneiDr.85307.

3D structure databases

ProteinModelPortaliA1A5X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000084255.

Proteomic databases

PaxDbiA1A5X2.
PeptideAtlasiA1A5X2.
PRIDEiA1A5X2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000089822; ENSDARP00000084255; ENSDARG00000062251.
GeneIDi569430.
KEGGidre:569430.

Organism-specific databases

CTDi23194.
ZFINiZDB-GENE-061215-122. fbxl7.

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiA1A5X2.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG091G06QE.
PhylomeDBiA1A5X2.
TreeFamiTF313434.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-DRE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiA1A5X2.

Gene expression databases

BgeeiENSDARG00000062251.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 4 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 10 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL7_DANRE
AccessioniPrimary (citable) accession number: A1A5X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.