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A1A5X2

- FBXL7_DANRE

UniProt

A1A5X2 - FBXL7_DANRE

Protein

F-box/LRR-repeat protein 7

Gene

fbxl7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

    Pathwayi

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/LRR-repeat protein 7
    Alternative name(s):
    F-box and leucine-rich repeat protein 7
    Gene namesi
    Name:fbxl7
    ORF Names:zgc:158346
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 2

    Organism-specific databases

    ZFINiZDB-GENE-061215-122. zgc:158346.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Localizes to the centrosome during spindle formation.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. microtubule organizing center Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489F-box/LRR-repeat protein 7PRO_0000417991Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA1A5X2.

    Interactioni

    Subunit structurei

    Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7).By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000084255.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A5X2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 15547F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati168 – 19326LRR 1Add
    BLAST
    Repeati194 – 21926LRR 2Add
    BLAST
    Repeati220 – 24526LRR 3Add
    BLAST
    Repeati251 – 27929LRR 4Add
    BLAST
    Repeati280 – 30526LRR 5Add
    BLAST
    Repeati306 – 33126LRR 6Add
    BLAST
    Repeati332 – 35726LRR 7Add
    BLAST
    Repeati358 – 38326LRR 8Add
    BLAST
    Repeati384 – 40926LRR 9Add
    BLAST
    Repeati410 – 43526LRR 10Add
    BLAST
    Repeati436 – 46126LRR 11Add
    BLAST

    Sequence similaritiesi

    Belongs to the FBXL7 family.Curated
    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 11 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG259371.
    GeneTreeiENSGT00750000117590.
    HOGENOMiHOG000116328.
    HOVERGENiHBG051591.
    InParanoidiA1A5X2.
    KOiK10273.
    OMAiLMLETVI.
    OrthoDBiEOG75MVWQ.
    PhylomeDBiA1A5X2.
    TreeFamiTF313434.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 3 hits.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A5X2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGANNGKQSG SEGKGSSSIS SDLSSSTDQT STKAPKNAAT SEDSDLSMRT    50
    VSTPSPALIL PPRSSSAVLN GSSTSSSTFG TETIAMVHMP PTSLTHPQRC 100
    LRQPRDQQGA PVDILPDHAF LQIFTHLPTN QLCRCARVCR RWYNLAWDPR 150
    LWRTIRLTGD VLHVDRALRV LTRRLCQDTP NVCLTVETVM VSGCRRLTDR 200
    GLYTVAQSCP ELRRLEVAGC YNVSNEAVFE VVSRCPNLEH LDVSGCSKVT 250
    CISLTRDVSV KLSPLHGQQI SIRFLDMTDC FALEDEGLHT IAAHCTQLTH 300
    LYLRRCVRLT DEGLRFLVIY CPGVRELSVS DCRFISDFGL REIAKLEGRL 350
    RYLSIAHCSR ITDVGVRYVA KYCSRLRYLN ARGCEGLTDH GIEHLAKSCL 400
    KLKSLDIGKC PLVSDAGLEQ LALNSFNLKR LSLKSCESIT GRGLQVVAAN 450
    CFDLQLLNVQ DCDVSLEALR FVKRHCKRCI IEHTNPAFF 489
    Length:489
    Mass (Da):54,220
    Last modified:January 23, 2007 - v1
    Checksum:i4C611A29877AB9D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR450710 Genomic DNA. No translation available.
    BC128845 mRNA. Translation: AAI28846.1.
    BC129207 mRNA. Translation: AAI29208.1.
    RefSeqiNP_001073511.1. NM_001080042.1.
    UniGeneiDr.85307.

    Genome annotation databases

    EnsembliENSDART00000089822; ENSDARP00000084255; ENSDARG00000062251.
    GeneIDi569430.
    KEGGidre:569430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR450710 Genomic DNA. No translation available.
    BC128845 mRNA. Translation: AAI28846.1 .
    BC129207 mRNA. Translation: AAI29208.1 .
    RefSeqi NP_001073511.1. NM_001080042.1.
    UniGenei Dr.85307.

    3D structure databases

    ProteinModelPortali A1A5X2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000084255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000089822 ; ENSDARP00000084255 ; ENSDARG00000062251 .
    GeneIDi 569430.
    KEGGi dre:569430.

    Organism-specific databases

    ZFINi ZDB-GENE-061215-122. zgc:158346.

    Phylogenomic databases

    eggNOGi NOG259371.
    GeneTreei ENSGT00750000117590.
    HOGENOMi HOG000116328.
    HOVERGENi HBG051591.
    InParanoidi A1A5X2.
    KOi K10273.
    OMAi LMLETVI.
    OrthoDBi EOG75MVWQ.
    PhylomeDBi A1A5X2.
    TreeFami TF313434.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 20889672.
    PROi A1A5X2.

    Gene expression databases

    Bgeei A1A5X2.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiFBXL7_DANRE
    AccessioniPrimary (citable) accession number: A1A5X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2012
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3