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A1A5X2

- FBXL7_DANRE

UniProt

A1A5X2 - FBXL7_DANRE

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Protein
F-box/LRR-repeat protein 7
Gene
fbxl7, zgc:158346
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
Gene namesi
Name:fbxl7
ORF Names:zgc:158346
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-061215-122. zgc:158346.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Localizes to the centrosome during spindle formation By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489F-box/LRR-repeat protein 7
PRO_0000417991Add
BLAST

Expressioni

Gene expression databases

BgeeiA1A5X2.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) By similarity.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000084255.

Structurei

3D structure databases

ProteinModelPortaliA1A5X2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 15547F-box
Add
BLAST
Repeati168 – 19326LRR 1
Add
BLAST
Repeati194 – 21926LRR 2
Add
BLAST
Repeati220 – 24526LRR 3
Add
BLAST
Repeati251 – 27929LRR 4
Add
BLAST
Repeati280 – 30526LRR 5
Add
BLAST
Repeati306 – 33126LRR 6
Add
BLAST
Repeati332 – 35726LRR 7
Add
BLAST
Repeati358 – 38326LRR 8
Add
BLAST
Repeati384 – 40926LRR 9
Add
BLAST
Repeati410 – 43526LRR 10
Add
BLAST
Repeati436 – 46126LRR 11
Add
BLAST

Sequence similaritiesi

Belongs to the FBXL7 family.
Contains 1 F-box domain.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG259371.
GeneTreeiENSGT00750000117590.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiA1A5X2.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG75MVWQ.
PhylomeDBiA1A5X2.
TreeFamiTF313434.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5X2-1 [UniParc]FASTAAdd to Basket

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MGANNGKQSG SEGKGSSSIS SDLSSSTDQT STKAPKNAAT SEDSDLSMRT    50
VSTPSPALIL PPRSSSAVLN GSSTSSSTFG TETIAMVHMP PTSLTHPQRC 100
LRQPRDQQGA PVDILPDHAF LQIFTHLPTN QLCRCARVCR RWYNLAWDPR 150
LWRTIRLTGD VLHVDRALRV LTRRLCQDTP NVCLTVETVM VSGCRRLTDR 200
GLYTVAQSCP ELRRLEVAGC YNVSNEAVFE VVSRCPNLEH LDVSGCSKVT 250
CISLTRDVSV KLSPLHGQQI SIRFLDMTDC FALEDEGLHT IAAHCTQLTH 300
LYLRRCVRLT DEGLRFLVIY CPGVRELSVS DCRFISDFGL REIAKLEGRL 350
RYLSIAHCSR ITDVGVRYVA KYCSRLRYLN ARGCEGLTDH GIEHLAKSCL 400
KLKSLDIGKC PLVSDAGLEQ LALNSFNLKR LSLKSCESIT GRGLQVVAAN 450
CFDLQLLNVQ DCDVSLEALR FVKRHCKRCI IEHTNPAFF 489
Length:489
Mass (Da):54,220
Last modified:January 23, 2007 - v1
Checksum:i4C611A29877AB9D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR450710 Genomic DNA. No translation available.
BC128845 mRNA. Translation: AAI28846.1.
BC129207 mRNA. Translation: AAI29208.1.
RefSeqiNP_001073511.1. NM_001080042.1.
UniGeneiDr.85307.

Genome annotation databases

EnsembliENSDART00000089822; ENSDARP00000084255; ENSDARG00000062251.
GeneIDi569430.
KEGGidre:569430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR450710 Genomic DNA. No translation available.
BC128845 mRNA. Translation: AAI28846.1 .
BC129207 mRNA. Translation: AAI29208.1 .
RefSeqi NP_001073511.1. NM_001080042.1.
UniGenei Dr.85307.

3D structure databases

ProteinModelPortali A1A5X2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000084255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000089822 ; ENSDARP00000084255 ; ENSDARG00000062251 .
GeneIDi 569430.
KEGGi dre:569430.

Organism-specific databases

ZFINi ZDB-GENE-061215-122. zgc:158346.

Phylogenomic databases

eggNOGi NOG259371.
GeneTreei ENSGT00750000117590.
HOGENOMi HOG000116328.
HOVERGENi HBG051591.
InParanoidi A1A5X2.
KOi K10273.
OMAi LMLETVI.
OrthoDBi EOG75MVWQ.
PhylomeDBi A1A5X2.
TreeFami TF313434.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 20889672.
PROi A1A5X2.

Gene expression databases

Bgeei A1A5X2.

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00367. LRR_CC. 3 hits.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiFBXL7_DANRE
AccessioniPrimary (citable) accession number: A1A5X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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