Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-arachidonyl glycine receptor

Gene

Gpr18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:24431468). However, conflicting results about the role of NAGly as an agonist are reported (By similarity). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24431468). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (By similarity). May contribute to regulation of the immune system (By similarity). Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (PubMed:24431468). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-373076 Class A/1 (Rhodopsin-like receptors)
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
N-arachidonyl glycine receptor
Short name:
NAGly receptor
Alternative name(s):
G-protein coupled receptor 18
Gene namesi
Name:Gpr18Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1304889 Gpr18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 56CytoplasmicSequence analysis9
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 95ExtracellularSequence analysisAdd BLAST18
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 138CytoplasmicSequence analysisAdd BLAST22
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 191ExtracellularSequence analysisAdd BLAST32
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 236CytoplasmicSequence analysisAdd BLAST24
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 268ExtracellularSequence analysisAdd BLAST11
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 331CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002781751 – 331N-arachidonyl glycine receptorAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei322PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA1A5S3
PRIDEiA1A5S3

PTM databases

iPTMnetiA1A5S3
PhosphoSitePlusiA1A5S3

Expressioni

Tissue specificityi

Expressed in testis, spleen and brain (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000012628

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016848

Structurei

3D structure databases

ProteinModelPortaliA1A5S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPC Eukaryota
ENOG410YP7X LUCA
GeneTreeiENSGT00910000143980
HOGENOMiHOG000112785
HOVERGENiHBG105013
InParanoidiA1A5S3
KOiK08410
OMAiSLPFRMF
OrthoDBiEOG091G0BF1
PhylomeDBiA1A5S3
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028335 GPR18
PANTHERiPTHR24232:SF1 PTHR24232:SF1, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1A5S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPSNRDQL ALSNGSHPEE YKIAALVFYS CIFLIGLLVN VTALWVFSCT
60 70 80 90 100
TKKRTTVTIY MMNVALLDLV FILSLPFRMF YYAKGEWPFG DYFCHILGAL
110 120 130 140 150
VVFYPSLALW LLALISADRY MAIVQPKYAK ELKNTGKAVL ACVGVWIMTL
160 170 180 190 200
TTTVPLLLLD EDPDKASSPA TCLKISDIIH LKAVNVLNFT RLIFFFLIPL
210 220 230 240 250
FIMIGCYVVI IHSLLRGQTS KLKPKVKEKS IRIIVTLLLQ VLACFVPFHI
260 270 280 290 300
CFALLMLQGE ENSYSPWGAF TTFLMNLSTC LDVVLYYIVS KQFQARVISV
310 320 330
MLYRNYLRSV RRKSVRSGSL RSLSNMNSEM L
Length:331
Mass (Da):37,556
Last modified:January 23, 2007 - v1
Checksum:iF33341AA4FCC67C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128782 mRNA Translation: AAI28783.1
RefSeqiNP_001073178.1, NM_001079710.1
UniGeneiRn.205907

Genome annotation databases

EnsembliENSRNOT00000016848; ENSRNOP00000016848; ENSRNOG00000012628
GeneIDi679957
KEGGirno:679957

Similar proteinsi

Entry informationi

Entry nameiGPR18_RAT
AccessioniPrimary (citable) accession number: A1A5S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health