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Protein

RNA binding protein fox-1 homolog 2

Gene

Rbfox2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-6803529. FGFR2 alternative splicing.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 2
Alternative name(s):
Fox-1 homolog B
RNA-binding motif protein 9
RNA-binding protein 9
Gene namesi
Name:Rbfox2
Synonyms:Fox2, Rbm9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1311838. Rbfox2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171161 – 432RNA binding protein fox-1 homolog 2Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323Omega-N-methylarginineBy similarity1
Modified residuei339Asymmetric dimethylarginineBy similarity1
Modified residuei371Asymmetric dimethylarginineBy similarity1
Modified residuei423Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei423Omega-N-methylarginine; alternateBy similarity1
Modified residuei428Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei428Omega-N-methylarginine; alternateBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiA1A5R1.
PeptideAtlasiA1A5R1.
PRIDEiA1A5R1.

PTM databases

PhosphoSitePlusiA1A5R1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004688.
ExpressionAtlasiA1A5R1. baseline and differential.
GenevisibleiA1A5R1. RN.

Interactioni

Subunit structurei

Interacts with ER-alpha N-terminal activation domain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei164Interaction with RNABy similarity1
Sitei172Interaction with RNABy similarity1
Sitei173Interaction with RNABy similarity1
Sitei197Interaction with RNABy similarity1
Sitei202Interaction with RNABy similarity1
Sitei206Interaction with RNABy similarity1
Sitei230Interaction with RNABy similarity1
Sitei240Interaction with RNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063462.

Structurei

3D structure databases

ProteinModelPortaliA1A5R1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 239RRMPROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi315 – 419Ala-richAdd BLAST105

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOVERGENiHBG000044.
InParanoidiA1A5R1.
KOiK14946.
OrthoDBiEOG091G15X5.
PhylomeDBiA1A5R1.
TreeFamiTF315942.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGQAQQQ PPQLGPGAAA RGMKRESEVE LPVPGAGADG PEPGLSKRPR
60 70 80 90 100
TEEAADEGMQ GNQEPTTTPD AMVQPFTTIP FPPPPQNGIP TEYGVPHTQD
110 120 130 140 150
YAGQTSEHNL TLYGSSQPHG EQSSNSPSNQ NGSLTQTEGG AQTDGQQSQT
160 170 180 190 200
QSSENSESKS TPKRLHVSNI PFRFRDPDLR QMFGQFGKIL DVEIIFNERG
210 220 230 240 250
SKGFGFVTFE NSADADRARE KLHGTVVEGR KIEVNNATAR VMTNKKMVTP
260 270 280 290 300
YANGWKLSPV VGAVYGPELY AASSFQADVS LGNEAAVPLS GRGGINTYIP
310 320 330 340 350
LISLPLVPGF PYPTAATTAA AFRGAHLRGR GRTVYGAVRA VPPTAIPAYP
360 370 380 390 400
GVVYQDGFYG ADLYGGYAAY RYAQPATATA ATAAAAAAAA YSDGYGRVYT
410 420 430
ADPYHALAPA ASYGVGAVAS LYRGGYSRFA PY
Length:432
Mass (Da):45,550
Last modified:January 23, 2007 - v1
Checksum:iE7CA07BB0DBA16B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128766 mRNA. Translation: AAI28767.1.
RefSeqiNP_001073364.1. NM_001079895.1.
UniGeneiRn.137551.

Genome annotation databases

EnsembliENSRNOT00000066431; ENSRNOP00000063462; ENSRNOG00000004688.
GeneIDi362950.
KEGGirno:362950.
UCSCiRGD:1311838. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128766 mRNA. Translation: AAI28767.1.
RefSeqiNP_001073364.1. NM_001079895.1.
UniGeneiRn.137551.

3D structure databases

ProteinModelPortaliA1A5R1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063462.

PTM databases

PhosphoSitePlusiA1A5R1.

Proteomic databases

PaxDbiA1A5R1.
PeptideAtlasiA1A5R1.
PRIDEiA1A5R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066431; ENSRNOP00000063462; ENSRNOG00000004688.
GeneIDi362950.
KEGGirno:362950.
UCSCiRGD:1311838. rat.

Organism-specific databases

CTDi23543.
RGDi1311838. Rbfox2.

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOVERGENiHBG000044.
InParanoidiA1A5R1.
KOiK14946.
OrthoDBiEOG091G15X5.
PhylomeDBiA1A5R1.
TreeFamiTF315942.

Enzyme and pathway databases

ReactomeiR-RNO-6803529. FGFR2 alternative splicing.

Miscellaneous databases

PROiA1A5R1.

Gene expression databases

BgeeiENSRNOG00000004688.
ExpressionAtlasiA1A5R1. baseline and differential.
GenevisibleiA1A5R1. RN.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFOX2_RAT
AccessioniPrimary (citable) accession number: A1A5R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.