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Protein

Leiomodin-2

Gene

Lmod2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leiomodin-2
Alternative name(s):
Cardiac leiomodin
Short name:
C-LMOD
Leiomodin1 Publication
Gene namesi
Name:Lmod2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1592092 Lmod2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113421 – 549Leiomodin-2Add BLAST549

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1A5Q0
PeptideAtlasiA1A5Q0
PRIDEiA1A5Q0

PTM databases

iPTMnetiA1A5Q0
PhosphoSitePlusiA1A5Q0

Interactioni

Subunit structurei

Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation. Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus). May also interact with TPM2 (via N-terminus).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067847

Structurei

3D structure databases

ProteinModelPortaliA1A5Q0
SMRiA1A5Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini523 – 542WH2Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 164Interaction with actin 1By similarityAdd BLAST164
Regioni1 – 47Interaction with tropomyosin alphaBy similarityAdd BLAST47
Regioni1 – 42Tropomyosin-bindingBy similarityAdd BLAST42
Regioni165 – 499Interaction with actin 2By similarityAdd BLAST335
Regioni523 – 542Interaction with actin 3By similarityAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili457 – 515Sequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 145Glu-richAdd BLAST132
Compositional biasi391 – 452Pro-richAdd BLAST62

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
HOVERGENiHBG056172
InParanoidiA1A5Q0
KOiK22030
PhylomeDBiA1A5Q0

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR030132 LMOD2
IPR032675 LRR_dom_sf
IPR004934 TMOD
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF12 PTHR10901:SF12, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit

Sequencei

Sequence statusi: Complete.

A1A5Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFGYRRGL SKYESIDEDE LLASLTAEEL KELERELEDI EPDRNLPVGL
60 70 80 90 100
RQKSLTEKTP TGNFSREALM AYWEKESQKL LEKERLGECG KLAEEDKEES
110 120 130 140 150
EEELIFTESN SEVSEEVCTE EEEESTEEEE EEEEEDSEEE EVTTEVTKHI
160 170 180 190 200
NGTVSHNGVN PDNSKPKTFK SQIENINLTN GNSGGTQRNT ESPAAIHPCG
210 220 230 240 250
NPTVIEDALE KIKNNDPDTT EVNLNNIENI TTQTLSRFAE ALKENTVVKT
260 270 280 290 300
FSLANTHADD AAAIAIAEML KVNEHITSVN VESNFITGKG ILAIMRALQH
310 320 330 340 350
NTVLTELRFH NQRHIMGSQV EMEIVKLLKE NTTLLRLGYH FELPGPRMSM
360 370 380 390 400
TSILTRNMDK QRQKRMQEQK QQEGHDGGAT LRTKVWQRGT PGSSPYASPR
410 420 430 440 450
QSPWSSPKVS KKVHTGRSRP PSPVAPPPPP PPPPLPPHML PPPPPPPAPP
460 470 480 490 500
LPGKKLITRN IAEVIKQQES AQRALQNGQR KKKGKKVKKQ PNNILKEIKN
510 520 530 540
SLRSVQEKKM EESSRPSTPQ RSAHENLMEA IRGSSIRQLR RVEVPEALR
Length:549
Mass (Da):61,717
Last modified:January 23, 2007 - v1
Checksum:i3494F88AEA5C395C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128755 mRNA Translation: AAI28756.1
RefSeqiNP_001094434.1, NM_001100964.1
UniGeneiRn.16210

Genome annotation databases

GeneIDi296935
KEGGirno:296935

Similar proteinsi

Entry informationi

Entry nameiLMOD2_RAT
AccessioniPrimary (citable) accession number: A1A5Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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