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A1A5Q0

- LMOD2_RAT

UniProt

A1A5Q0 - LMOD2_RAT

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Protein

Leiomodin-2

Gene
Lmod2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May block the elongation and depolymerization of the actin filaments at the pointed end By similarity.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leiomodin-2
Alternative name(s):
Cardiac leiomodin
Short name:
C-LMOD
Gene namesi
Name:Lmod2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1592092. Lmod2.

Subcellular locationi

GO - Cellular componenti

  1. cytoskeleton Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Leiomodin-2PRO_0000311342Add
BLAST

Proteomic databases

PRIDEiA1A5Q0.

PTM databases

PhosphoSiteiA1A5Q0.

Expressioni

Gene expression databases

GenevestigatoriA1A5Q0.

Interactioni

Subunit structurei

Able to bind to tropomyosin By similarity.

Structurei

3D structure databases

ProteinModelPortaliA1A5Q0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini523 – 54220WH2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4242Tropomyosin-binding By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili457 – 51559 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 145132Glu-richAdd
BLAST
Compositional biasi391 – 45262Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the tropomodulin family.
Contains 1 WH2 domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG056172.
PhylomeDBiA1A5Q0.

Family and domain databases

InterProiIPR004934. Tropomodulin.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5Q0-1 [UniParc]FASTAAdd to Basket

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MSTFGYRRGL SKYESIDEDE LLASLTAEEL KELERELEDI EPDRNLPVGL    50
RQKSLTEKTP TGNFSREALM AYWEKESQKL LEKERLGECG KLAEEDKEES 100
EEELIFTESN SEVSEEVCTE EEEESTEEEE EEEEEDSEEE EVTTEVTKHI 150
NGTVSHNGVN PDNSKPKTFK SQIENINLTN GNSGGTQRNT ESPAAIHPCG 200
NPTVIEDALE KIKNNDPDTT EVNLNNIENI TTQTLSRFAE ALKENTVVKT 250
FSLANTHADD AAAIAIAEML KVNEHITSVN VESNFITGKG ILAIMRALQH 300
NTVLTELRFH NQRHIMGSQV EMEIVKLLKE NTTLLRLGYH FELPGPRMSM 350
TSILTRNMDK QRQKRMQEQK QQEGHDGGAT LRTKVWQRGT PGSSPYASPR 400
QSPWSSPKVS KKVHTGRSRP PSPVAPPPPP PPPPLPPHML PPPPPPPAPP 450
LPGKKLITRN IAEVIKQQES AQRALQNGQR KKKGKKVKKQ PNNILKEIKN 500
SLRSVQEKKM EESSRPSTPQ RSAHENLMEA IRGSSIRQLR RVEVPEALR 549
Length:549
Mass (Da):61,717
Last modified:January 23, 2007 - v1
Checksum:i3494F88AEA5C395C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128755 mRNA. Translation: AAI28756.1.
RefSeqiNP_001094434.1. NM_001100964.1.
UniGeneiRn.16210.

Genome annotation databases

GeneIDi296935.
KEGGirno:296935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128755 mRNA. Translation: AAI28756.1 .
RefSeqi NP_001094434.1. NM_001100964.1.
UniGenei Rn.16210.

3D structure databases

ProteinModelPortali A1A5Q0.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A1A5Q0.

Proteomic databases

PRIDEi A1A5Q0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 296935.
KEGGi rno:296935.

Organism-specific databases

CTDi 442721.
RGDi 1592092. Lmod2.

Phylogenomic databases

HOVERGENi HBG056172.
PhylomeDBi A1A5Q0.

Miscellaneous databases

NextBioi 641912.
PROi A1A5Q0.

Gene expression databases

Genevestigatori A1A5Q0.

Family and domain databases

InterProi IPR004934. Tropomodulin.
[Graphical view ]
PANTHERi PTHR10901. PTHR10901. 1 hit.
Pfami PF03250. Tropomodulin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiLMOD2_RAT
AccessioniPrimary (citable) accession number: A1A5Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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