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A1A5Q0

- LMOD2_RAT

UniProt

A1A5Q0 - LMOD2_RAT

Protein

Leiomodin-2

Gene

Lmod2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May block the elongation and depolymerization of the actin filaments at the pointed end.By similarity

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leiomodin-2
    Alternative name(s):
    Cardiac leiomodin
    Short name:
    C-LMOD
    Gene namesi
    Name:Lmod2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1592092. Lmod2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Leiomodin-2PRO_0000311342Add
    BLAST

    Proteomic databases

    PRIDEiA1A5Q0.

    PTM databases

    PhosphoSiteiA1A5Q0.

    Expressioni

    Gene expression databases

    GenevestigatoriA1A5Q0.

    Interactioni

    Subunit structurei

    Able to bind to tropomyosin.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA1A5Q0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini523 – 54220WH2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4242Tropomyosin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili457 – 51559Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 145132Glu-richAdd
    BLAST
    Compositional biasi391 – 45262Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the tropomodulin family.Curated
    Contains 1 WH2 domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOVERGENiHBG056172.
    PhylomeDBiA1A5Q0.

    Family and domain databases

    InterProiIPR004934. Tropomodulin.
    [Graphical view]
    PANTHERiPTHR10901. PTHR10901. 1 hit.
    PfamiPF03250. Tropomodulin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A5Q0-1 [UniParc]FASTAAdd to Basket

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    MSTFGYRRGL SKYESIDEDE LLASLTAEEL KELERELEDI EPDRNLPVGL    50
    RQKSLTEKTP TGNFSREALM AYWEKESQKL LEKERLGECG KLAEEDKEES 100
    EEELIFTESN SEVSEEVCTE EEEESTEEEE EEEEEDSEEE EVTTEVTKHI 150
    NGTVSHNGVN PDNSKPKTFK SQIENINLTN GNSGGTQRNT ESPAAIHPCG 200
    NPTVIEDALE KIKNNDPDTT EVNLNNIENI TTQTLSRFAE ALKENTVVKT 250
    FSLANTHADD AAAIAIAEML KVNEHITSVN VESNFITGKG ILAIMRALQH 300
    NTVLTELRFH NQRHIMGSQV EMEIVKLLKE NTTLLRLGYH FELPGPRMSM 350
    TSILTRNMDK QRQKRMQEQK QQEGHDGGAT LRTKVWQRGT PGSSPYASPR 400
    QSPWSSPKVS KKVHTGRSRP PSPVAPPPPP PPPPLPPHML PPPPPPPAPP 450
    LPGKKLITRN IAEVIKQQES AQRALQNGQR KKKGKKVKKQ PNNILKEIKN 500
    SLRSVQEKKM EESSRPSTPQ RSAHENLMEA IRGSSIRQLR RVEVPEALR 549
    Length:549
    Mass (Da):61,717
    Last modified:January 23, 2007 - v1
    Checksum:i3494F88AEA5C395C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128755 mRNA. Translation: AAI28756.1.
    RefSeqiNP_001094434.1. NM_001100964.1.
    UniGeneiRn.16210.

    Genome annotation databases

    GeneIDi296935.
    KEGGirno:296935.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128755 mRNA. Translation: AAI28756.1 .
    RefSeqi NP_001094434.1. NM_001100964.1.
    UniGenei Rn.16210.

    3D structure databases

    ProteinModelPortali A1A5Q0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A1A5Q0.

    Proteomic databases

    PRIDEi A1A5Q0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 296935.
    KEGGi rno:296935.

    Organism-specific databases

    CTDi 442721.
    RGDi 1592092. Lmod2.

    Phylogenomic databases

    HOVERGENi HBG056172.
    PhylomeDBi A1A5Q0.

    Miscellaneous databases

    NextBioi 641912.
    PROi A1A5Q0.

    Gene expression databases

    Genevestigatori A1A5Q0.

    Family and domain databases

    InterProi IPR004934. Tropomodulin.
    [Graphical view ]
    PANTHERi PTHR10901. PTHR10901. 1 hit.
    Pfami PF03250. Tropomodulin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiLMOD2_RAT
    AccessioniPrimary (citable) accession number: A1A5Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3