A1A5Q0 (LMOD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leiomodin-2

Alternative name(s):
Cardiac leiomodin
Short name=C-LMOD

Gene names

Name:

Lmod2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May block the elongation and depolymerization of the actin filaments at the pointed end By similarity.
Subunit structure	Able to bind to tropomyosin By similarity.
Sequence similarities	Belongs to the tropomodulin family. Contains 1 WH2 domain.

Ontologies

Keywords
Domain	Coiled coil
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Leiomodin-2		PRO_0000311342
Regions
	Domain	523 – 542	20	WH2
	Region	1 – 42	42	Tropomyosin-binding By similarity
	Coiled coil	457 – 515	59	Potential
	Compositional bias	14 – 145	132	Glu-rich
	Compositional bias	391 – 452	62	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	A1A5Q0 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 3494F88AEA5C395C	FASTA	549	61,717
	10 20 30 40 50 60 MSTFGYRRGL SKYESIDEDE LLASLTAEEL KELERELEDI EPDRNLPVGL RQKSLTEKTP 70 80 90 100 110 120 TGNFSREALM AYWEKESQKL LEKERLGECG KLAEEDKEES EEELIFTESN SEVSEEVCTE 130 140 150 160 170 180 EEEESTEEEE EEEEEDSEEE EVTTEVTKHI NGTVSHNGVN PDNSKPKTFK SQIENINLTN 190 200 210 220 230 240 GNSGGTQRNT ESPAAIHPCG NPTVIEDALE KIKNNDPDTT EVNLNNIENI TTQTLSRFAE 250 260 270 280 290 300 ALKENTVVKT FSLANTHADD AAAIAIAEML KVNEHITSVN VESNFITGKG ILAIMRALQH 310 320 330 340 350 360 NTVLTELRFH NQRHIMGSQV EMEIVKLLKE NTTLLRLGYH FELPGPRMSM TSILTRNMDK 370 380 390 400 410 420 QRQKRMQEQK QQEGHDGGAT LRTKVWQRGT PGSSPYASPR QSPWSSPKVS KKVHTGRSRP 430 440 450 460 470 480 PSPVAPPPPP PPPPLPPHML PPPPPPPAPP LPGKKLITRN IAEVIKQQES AQRALQNGQR 490 500 510 520 530 540 KKKGKKVKKQ PNNILKEIKN SLRSVQEKKM EESSRPSTPQ RSAHENLMEA IRGSSIRQLR RVEVPEALR

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC128755 mRNA. Translation: AAI28756.1.
IPI	IPI00372026.
RefSeq	NP_001094434.1. NM_001100964.1.
UniGene	Rn.16210.
3D structure databases
ProteinModelPortal	A1A5Q0.
ModBase	Search...
PTM databases
PhosphoSite	A1A5Q0.
Proteomic databases
PRIDE	A1A5Q0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	296935.
KEGG	rno:296935.
Organism-specific databases
CTD	442721.
RGD	1592092. Lmod2.
Phylogenomic databases
HOVERGEN	HBG056172.
Gene expression databases
Genevestigator	A1A5Q0.
Family and domain databases
InterPro	IPR004934. Tropomodulin. [Graphical view]
PANTHER	PTHR10901. PTHR10901. 1 hit.
Pfam	PF03250. Tropomodulin. 1 hit. [Graphical view]
PROSITE	PS51082. WH2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	641912.

Entry information

Entry name

LMOD2_RAT

Accession

Primary (citable) accession number: A1A5Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	January 23, 2007
Last modified:	October 3, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program