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A1A5Q0 (LMOD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leiomodin-2
Alternative name(s):
Cardiac leiomodin
Short name=C-LMOD
Gene names
Name:Lmod2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May block the elongation and depolymerization of the actin filaments at the pointed end By similarity.

Subunit structure

Able to bind to tropomyosin By similarity.

Sequence similarities

Belongs to the tropomodulin family.

Contains 1 WH2 domain.

Ontologies

Keywords
   DomainCoiled coil
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Leiomodin-2
PRO_0000311342

Regions

Domain523 – 54220WH2
Region1 – 4242Tropomyosin-binding By similarity
Coiled coil457 – 51559 Potential
Compositional bias14 – 145132Glu-rich
Compositional bias391 – 45262Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A1A5Q0 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 3494F88AEA5C395C

FASTA54961,717
        10         20         30         40         50         60 
MSTFGYRRGL SKYESIDEDE LLASLTAEEL KELERELEDI EPDRNLPVGL RQKSLTEKTP 

        70         80         90        100        110        120 
TGNFSREALM AYWEKESQKL LEKERLGECG KLAEEDKEES EEELIFTESN SEVSEEVCTE 

       130        140        150        160        170        180 
EEEESTEEEE EEEEEDSEEE EVTTEVTKHI NGTVSHNGVN PDNSKPKTFK SQIENINLTN 

       190        200        210        220        230        240 
GNSGGTQRNT ESPAAIHPCG NPTVIEDALE KIKNNDPDTT EVNLNNIENI TTQTLSRFAE 

       250        260        270        280        290        300 
ALKENTVVKT FSLANTHADD AAAIAIAEML KVNEHITSVN VESNFITGKG ILAIMRALQH 

       310        320        330        340        350        360 
NTVLTELRFH NQRHIMGSQV EMEIVKLLKE NTTLLRLGYH FELPGPRMSM TSILTRNMDK 

       370        380        390        400        410        420 
QRQKRMQEQK QQEGHDGGAT LRTKVWQRGT PGSSPYASPR QSPWSSPKVS KKVHTGRSRP 

       430        440        450        460        470        480 
PSPVAPPPPP PPPPLPPHML PPPPPPPAPP LPGKKLITRN IAEVIKQQES AQRALQNGQR 

       490        500        510        520        530        540 
KKKGKKVKKQ PNNILKEIKN SLRSVQEKKM EESSRPSTPQ RSAHENLMEA IRGSSIRQLR 


RVEVPEALR 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC128755 mRNA. Translation: AAI28756.1.
RefSeqNP_001094434.1. NM_001100964.1.
UniGeneRn.16210.

3D structure databases

ProteinModelPortalA1A5Q0.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA1A5Q0.

Proteomic databases

PRIDEA1A5Q0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID296935.
KEGGrno:296935.

Organism-specific databases

CTD442721.
RGD1592092. Lmod2.

Phylogenomic databases

HOVERGENHBG056172.
PhylomeDBA1A5Q0.

Gene expression databases

GenevestigatorA1A5Q0.

Family and domain databases

InterProIPR004934. Tropomodulin.
[Graphical view]
PANTHERPTHR10901. PTHR10901. 1 hit.
PfamPF03250. Tropomodulin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio641912.
PROA1A5Q0.

Entry information

Entry nameLMOD2_RAT
AccessionPrimary (citable) accession number: A1A5Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families