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Protein

Cdc42 effector protein 1

Gene

Cdc42ep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 1
Alternative name(s):
Binder of Rho GTPases 5
Gene namesi
Name:Cdc42ep1Imported
Synonyms:Borg5By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1311131 Cdc42ep1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002781201 – 388Cdc42 effector protein 1Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei34PhosphothreonineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei53Omega-N-methylarginineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212PhosphoserineBy similarity1
Modified residuei298PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiA1A5P0
PeptideAtlasiA1A5P0
PRIDEiA1A5P0

PTM databases

iPTMnetiA1A5P0
PhosphoSitePlusiA1A5P0

Expressioni

Gene expression databases

BgeeiENSRNOG00000008517
GenevisibleiA1A5P0 RN

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011269

Structurei

3D structure databases

SMRiA1A5P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 52CRIBPROSITE-ProRule annotationAdd BLAST15
Repeati237 – 2431Sequence analysis7
Repeati250 – 2562Sequence analysis7

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni237 – 2702 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Sequence analysisAdd BLAST34

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGPN Eukaryota
ENOG4111PPX LUCA
GeneTreeiENSGT00730000110869
HOGENOMiHOG000095252
HOVERGENiHBG080906
InParanoidiA1A5P0
OMAiQANTFEF
OrthoDBiEOG091G0IY8
PhylomeDBiA1A5P0
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

A1A5P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPQGGTGA PSMSLGKLSP VGWVPSSHGK RRLTADMISP PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGR SGNTHRSPRS FLARKLQQVR RVGVPPRRMA
110 120 130 140 150
SPAATSPAPP PISPIIKNAI SLPQLNQATY DSLVVSKLSF DSTPASSTDG
160 170 180 190 200
RSGYGLESGF CTISRLPRVE KHSSRDRDHD RDPDHSQDRE QSSSPSEPNP
210 220 230 240 250
NPELRRSDSL LSFRFDLDLG PSLLSELLGV MSLSEAPAAN PPAPAANPAP
260 270 280 290 300
TAKPPADAVT TLDTVTSLPA PTASSPSSGR FPNGVTAVLG PVAEVKASPV
310 320 330 340 350
GEGPQVPSKM AFDRRGASWG AIRASRHYTE MDARRELAGV LPQVHGSWES
360 370 380
LNEEWSAPPA SSRAPVPSTV QANAFEFADA DEDDEVKV
Length:388
Mass (Da):41,029
Last modified:January 23, 2007 - v1
Checksum:i62D900F6AEDBEC3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128744 mRNA Translation: AAI28745.1
RefSeqiNP_001073168.1, NM_001079700.1
XP_017450354.1, XM_017594865.1
XP_017450355.1, XM_017594866.1
XP_017450356.1, XM_017594867.1
XP_017450357.1, XM_017594868.1
UniGeneiRn.164707

Genome annotation databases

EnsembliENSRNOT00000011270; ENSRNOP00000011269; ENSRNOG00000008517
GeneIDi315121
KEGGirno:315121

Similar proteinsi

Entry informationi

Entry nameiBORG5_RAT
AccessioniPrimary (citable) accession number: A1A5P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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