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Protein

Cdc42 effector protein 1

Gene

Cdc42ep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 1
Alternative name(s):
Binder of Rho GTPases 5
Gene namesi
Name:Cdc42ep1Imported
Synonyms:Borg5By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1311131. Cdc42ep1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002781201 – 388Cdc42 effector protein 1Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei34PhosphothreonineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei53Omega-N-methylarginineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212PhosphoserineBy similarity1
Modified residuei298PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiA1A5P0.
PeptideAtlasiA1A5P0.
PRIDEiA1A5P0.

PTM databases

iPTMnetiA1A5P0.
PhosphoSitePlusiA1A5P0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008517.
GenevisibleiA1A5P0. RN.

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011269.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 52CRIBPROSITE-ProRule annotationAdd BLAST15
Repeati237 – 2431Sequence analysis7
Repeati250 – 2562Sequence analysis7

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni237 – 2702 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Sequence analysisAdd BLAST34

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Sequence analysis
Contains 1 CRIB domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGPN. Eukaryota.
ENOG4111PPX. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000095252.
HOVERGENiHBG080906.
InParanoidiA1A5P0.
OMAiQANTFEF.
OrthoDBiEOG091G0IY8.
PhylomeDBiA1A5P0.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPQGGTGA PSMSLGKLSP VGWVPSSHGK RRLTADMISP PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGR SGNTHRSPRS FLARKLQQVR RVGVPPRRMA
110 120 130 140 150
SPAATSPAPP PISPIIKNAI SLPQLNQATY DSLVVSKLSF DSTPASSTDG
160 170 180 190 200
RSGYGLESGF CTISRLPRVE KHSSRDRDHD RDPDHSQDRE QSSSPSEPNP
210 220 230 240 250
NPELRRSDSL LSFRFDLDLG PSLLSELLGV MSLSEAPAAN PPAPAANPAP
260 270 280 290 300
TAKPPADAVT TLDTVTSLPA PTASSPSSGR FPNGVTAVLG PVAEVKASPV
310 320 330 340 350
GEGPQVPSKM AFDRRGASWG AIRASRHYTE MDARRELAGV LPQVHGSWES
360 370 380
LNEEWSAPPA SSRAPVPSTV QANAFEFADA DEDDEVKV
Length:388
Mass (Da):41,029
Last modified:January 23, 2007 - v1
Checksum:i62D900F6AEDBEC3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128744 mRNA. Translation: AAI28745.1.
RefSeqiNP_001073168.1. NM_001079700.1.
XP_017450354.1. XM_017594865.1.
XP_017450355.1. XM_017594866.1.
XP_017450356.1. XM_017594867.1.
XP_017450357.1. XM_017594868.1.
UniGeneiRn.164707.

Genome annotation databases

EnsembliENSRNOT00000011270; ENSRNOP00000011269; ENSRNOG00000008517.
GeneIDi315121.
KEGGirno:315121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128744 mRNA. Translation: AAI28745.1.
RefSeqiNP_001073168.1. NM_001079700.1.
XP_017450354.1. XM_017594865.1.
XP_017450355.1. XM_017594866.1.
XP_017450356.1. XM_017594867.1.
XP_017450357.1. XM_017594868.1.
UniGeneiRn.164707.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011269.

PTM databases

iPTMnetiA1A5P0.
PhosphoSitePlusiA1A5P0.

Proteomic databases

PaxDbiA1A5P0.
PeptideAtlasiA1A5P0.
PRIDEiA1A5P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011270; ENSRNOP00000011269; ENSRNOG00000008517.
GeneIDi315121.
KEGGirno:315121.

Organism-specific databases

CTDi11135.
RGDi1311131. Cdc42ep1.

Phylogenomic databases

eggNOGiENOG410IGPN. Eukaryota.
ENOG4111PPX. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000095252.
HOVERGENiHBG080906.
InParanoidiA1A5P0.
OMAiQANTFEF.
OrthoDBiEOG091G0IY8.
PhylomeDBiA1A5P0.
TreeFamiTF331725.

Miscellaneous databases

PROiA1A5P0.

Gene expression databases

BgeeiENSRNOG00000008517.
GenevisibleiA1A5P0. RN.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBORG5_RAT
AccessioniPrimary (citable) accession number: A1A5P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.