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A1A5G2 (UBP47_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 47

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene names
Name:usp47
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length1354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP47 subfamily.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13541354Ubiquitin carboxyl-terminal hydrolase 47
PRO_0000408359

Regions

Domain174 – 549376USP

Sites

Active site1831Nucleophile By similarity
Active site4881Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A1A5G2 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: E59BABE209E22310

FASTA1,354153,719
        10         20         30         40         50         60 
MRPGEESHLV PKEIENAADE PRVLCIVQDT TSCKNINERI TLNLPASTSV KQLYEDVSSK 

        70         80         90        100        110        120 
AGYVSGTFSL MWGNGASNMV DMAALDPTPD RTLQEAGFEA GKKNFLHLTD KNGEQPQLAS 

       130        140        150        160        170        180 
DESGTADSSG LDDSTQEKFI GPLPREESVA CTSDYVSQNY SYSSLLSKSD TGYVGLVNQA 

       190        200        210        220        230        240 
MTCYLNSLLQ TLFMTPEFRN ALYKWEFEES EEDPVSSIPY QLQRLFVLLQ TSKKRAIETT 

       250        260        270        280        290        300 
DVTRSFGWDS SEAWQQHDVQ ELCRVMFDAL EQKWKQTEQA DLINQLYQGK LKDYVKCLEC 

       310        320        330        340        350        360 
GYESWRIDTF LDIPLVIRPF GSNTAFGSME EALQAFIQPE TLDGPNQYFC ERCKRKCDAR 

       370        380        390        400        410        420 
KGLKFLHFPY LLTLQLKRFD FDYTSMHRIK LNDRMTFPDE LDMSPFIDVE DEKSPQTDSC 

       430        440        450        460        470        480 
TDSGAENEGS CHSDQMSNDF STDDAVDEGI CLETNSNIEK LNKSVSEKNS LYELFSVMVH 

       490        500        510        520        530        540 
SGSAAGGHYY ACIKSFADGQ WYSFNDQHVS RITQEDIKKT YGGSTGNRGY YSSAFASSTN 

       550        560        570        580        590        600 
AYMLMYRLKN PARNAKFPEA IEFPEHIKLL VQKEQEQEEQ EKRQREIERN TCKLKLFCMH 

       610        620        630        640        650        660 
PVKQIMMESK LEVHKDKTMK EAVEIAHKLM DLEGVISLDC CRLVKYDEFH DYLERSYEDE 

       670        680        690        700        710        720 
EDRTMGYLLG GVKSSYMFDL LLETKRSDQV FQSYKPGEVM VKVYVVDLKT ETVAPPVSVR 

       730        740        750        760        770        780 
AYLSQTIIEF KQLISKSVDL LPDTMRVVLE RCYNDLRLLN VANKTLKAEG FFRSNKVFVE 

       790        800        810        820        830        840 
SSDSLDYQLV FTDSHLWKLL DRHANTIRLY VSLPEHTPQT ARSVGPKGGG DSNLSEDYCS 

       850        860        870        880        890        900 
RVKGNVKSVD AILEESTEKL KSLSLQQHQD GGNGDSSKST EGSDFENIDS PLNEADSGSA 

       910        920        930        940        950        960 
DNRELENRIL PADPENNFQP EERSDSDVNN DRSTSSVDSD ILSSSHSSDT LCNADSAPIP 

       970        980        990       1000       1010       1020 
LANGLDSHSI TSSRRSKAND GKKETWDTAE EDSGTDSEYD ESGKSRGEAQ YMYFKAEPHA 

      1030       1040       1050       1060       1070       1080 
GEGCLGEGNK CLLVSVDKRI TLAAFKQQLE SFVGVSSSQF KVFRVYASNQ EFESVRLNET 

      1090       1100       1110       1120       1130       1140 
LSSFSDDNKI TIRLGRALKK GEYRVKIFQL LVNEPEPCKF LLDAVFSKGM TVRQSKEELL 

      1150       1160       1170       1180       1190       1200 
PLLRDQCGLD LSIDRFRLRK KTWKNPGTVF LDYHVYENES ISSSWEVFLE ALDETEKMKS 

      1210       1220       1230       1240       1250       1260 
MSQLSLFTKR WRPSELKLDP FKEIVMESNS VDELRDKICD ISAIPLENLE FAKGRGTFPC 

      1270       1280       1290       1300       1310       1320 
DISVLEIHQD LDWNPKVSTL NAWPLYISDD GAVIFYRDKM EELVELTDEQ RNDLAKKESS 

      1330       1340       1350 
RLQKTGHRVT YSPRKEKALK IYLDGPSNKD SSQD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC128636 mRNA. Translation: AAI28637.1.
RefSeqNP_001090710.1. NM_001097241.1.
UniGeneStr.45630.

3D structure databases

ProteinModelPortalA1A5G2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000029972.

Protein family/group databases

MEROPSC19.055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100036690.
KEGGxtr:100036690.

Organism-specific databases

CTD55031.
XenbaseXB-GENE-5760041. usp47.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000037524.
HOVERGENHBG058854.
KOK11857.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP47_XENTR
AccessionPrimary (citable) accession number: A1A5G2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries