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A1A5G2

- UBP47_XENTR

UniProt

A1A5G2 - UBP47_XENTR

Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

usp47

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER).By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei183 – 1831NucleophilePROSITE-ProRule annotation
    Active sitei488 – 4881Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. base-excision repair Source: UniProtKB
    2. cellular response to DNA damage stimulus Source: UniProtKB
    3. monoubiquitinated protein deubiquitination Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    DNA damage, DNA repair, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.055.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 47
    Ubiquitin thioesterase 47
    Ubiquitin-specific-processing protease 47
    Gene namesi
    Name:usp47
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5760041. usp47.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13541354Ubiquitin carboxyl-terminal hydrolase 47PRO_0000408359Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000029972.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A5G2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 549376USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP47 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000037524.
    HOVERGENiHBG058854.
    KOiK11857.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A5G2-1 [UniParc]FASTAAdd to Basket

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    MRPGEESHLV PKEIENAADE PRVLCIVQDT TSCKNINERI TLNLPASTSV     50
    KQLYEDVSSK AGYVSGTFSL MWGNGASNMV DMAALDPTPD RTLQEAGFEA 100
    GKKNFLHLTD KNGEQPQLAS DESGTADSSG LDDSTQEKFI GPLPREESVA 150
    CTSDYVSQNY SYSSLLSKSD TGYVGLVNQA MTCYLNSLLQ TLFMTPEFRN 200
    ALYKWEFEES EEDPVSSIPY QLQRLFVLLQ TSKKRAIETT DVTRSFGWDS 250
    SEAWQQHDVQ ELCRVMFDAL EQKWKQTEQA DLINQLYQGK LKDYVKCLEC 300
    GYESWRIDTF LDIPLVIRPF GSNTAFGSME EALQAFIQPE TLDGPNQYFC 350
    ERCKRKCDAR KGLKFLHFPY LLTLQLKRFD FDYTSMHRIK LNDRMTFPDE 400
    LDMSPFIDVE DEKSPQTDSC TDSGAENEGS CHSDQMSNDF STDDAVDEGI 450
    CLETNSNIEK LNKSVSEKNS LYELFSVMVH SGSAAGGHYY ACIKSFADGQ 500
    WYSFNDQHVS RITQEDIKKT YGGSTGNRGY YSSAFASSTN AYMLMYRLKN 550
    PARNAKFPEA IEFPEHIKLL VQKEQEQEEQ EKRQREIERN TCKLKLFCMH 600
    PVKQIMMESK LEVHKDKTMK EAVEIAHKLM DLEGVISLDC CRLVKYDEFH 650
    DYLERSYEDE EDRTMGYLLG GVKSSYMFDL LLETKRSDQV FQSYKPGEVM 700
    VKVYVVDLKT ETVAPPVSVR AYLSQTIIEF KQLISKSVDL LPDTMRVVLE 750
    RCYNDLRLLN VANKTLKAEG FFRSNKVFVE SSDSLDYQLV FTDSHLWKLL 800
    DRHANTIRLY VSLPEHTPQT ARSVGPKGGG DSNLSEDYCS RVKGNVKSVD 850
    AILEESTEKL KSLSLQQHQD GGNGDSSKST EGSDFENIDS PLNEADSGSA 900
    DNRELENRIL PADPENNFQP EERSDSDVNN DRSTSSVDSD ILSSSHSSDT 950
    LCNADSAPIP LANGLDSHSI TSSRRSKAND GKKETWDTAE EDSGTDSEYD 1000
    ESGKSRGEAQ YMYFKAEPHA GEGCLGEGNK CLLVSVDKRI TLAAFKQQLE 1050
    SFVGVSSSQF KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK 1100
    GEYRVKIFQL LVNEPEPCKF LLDAVFSKGM TVRQSKEELL PLLRDQCGLD 1150
    LSIDRFRLRK KTWKNPGTVF LDYHVYENES ISSSWEVFLE ALDETEKMKS 1200
    MSQLSLFTKR WRPSELKLDP FKEIVMESNS VDELRDKICD ISAIPLENLE 1250
    FAKGRGTFPC DISVLEIHQD LDWNPKVSTL NAWPLYISDD GAVIFYRDKM 1300
    EELVELTDEQ RNDLAKKESS RLQKTGHRVT YSPRKEKALK IYLDGPSNKD 1350
    SSQD 1354
    Length:1,354
    Mass (Da):153,719
    Last modified:January 23, 2007 - v1
    Checksum:iE59BABE209E22310
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128636 mRNA. Translation: AAI28637.1.
    RefSeqiNP_001090710.1. NM_001097241.1.
    UniGeneiStr.45630.

    Genome annotation databases

    GeneIDi100036690.
    KEGGixtr:100036690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128636 mRNA. Translation: AAI28637.1 .
    RefSeqi NP_001090710.1. NM_001097241.1.
    UniGenei Str.45630.

    3D structure databases

    ProteinModelPortali A1A5G2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000029972.

    Protein family/group databases

    MEROPSi C19.055.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100036690.
    KEGGi xtr:100036690.

    Organism-specific databases

    CTDi 55031.
    Xenbasei XB-GENE-5760041. usp47.

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000037524.
    HOVERGENi HBG058854.
    KOi K11857.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiUBP47_XENTR
    AccessioniPrimary (citable) accession number: A1A5G2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3