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A1A5G2

- UBP47_XENTR

UniProt

A1A5G2 - UBP47_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

usp47

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831NucleophilePROSITE-ProRule annotation
Active sitei488 – 4881Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. base-excision repair Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. monoubiquitinated protein deubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene namesi
Name:usp47
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5760041. usp47.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13541354Ubiquitin carboxyl-terminal hydrolase 47PRO_0000408359Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000029972.

Structurei

3D structure databases

ProteinModelPortaliA1A5G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 549376USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP47 subfamily.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000037524.
HOVERGENiHBG058854.
InParanoidiA1A5G2.
KOiK11857.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5G2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRPGEESHLV PKEIENAADE PRVLCIVQDT TSCKNINERI TLNLPASTSV
60 70 80 90 100
KQLYEDVSSK AGYVSGTFSL MWGNGASNMV DMAALDPTPD RTLQEAGFEA
110 120 130 140 150
GKKNFLHLTD KNGEQPQLAS DESGTADSSG LDDSTQEKFI GPLPREESVA
160 170 180 190 200
CTSDYVSQNY SYSSLLSKSD TGYVGLVNQA MTCYLNSLLQ TLFMTPEFRN
210 220 230 240 250
ALYKWEFEES EEDPVSSIPY QLQRLFVLLQ TSKKRAIETT DVTRSFGWDS
260 270 280 290 300
SEAWQQHDVQ ELCRVMFDAL EQKWKQTEQA DLINQLYQGK LKDYVKCLEC
310 320 330 340 350
GYESWRIDTF LDIPLVIRPF GSNTAFGSME EALQAFIQPE TLDGPNQYFC
360 370 380 390 400
ERCKRKCDAR KGLKFLHFPY LLTLQLKRFD FDYTSMHRIK LNDRMTFPDE
410 420 430 440 450
LDMSPFIDVE DEKSPQTDSC TDSGAENEGS CHSDQMSNDF STDDAVDEGI
460 470 480 490 500
CLETNSNIEK LNKSVSEKNS LYELFSVMVH SGSAAGGHYY ACIKSFADGQ
510 520 530 540 550
WYSFNDQHVS RITQEDIKKT YGGSTGNRGY YSSAFASSTN AYMLMYRLKN
560 570 580 590 600
PARNAKFPEA IEFPEHIKLL VQKEQEQEEQ EKRQREIERN TCKLKLFCMH
610 620 630 640 650
PVKQIMMESK LEVHKDKTMK EAVEIAHKLM DLEGVISLDC CRLVKYDEFH
660 670 680 690 700
DYLERSYEDE EDRTMGYLLG GVKSSYMFDL LLETKRSDQV FQSYKPGEVM
710 720 730 740 750
VKVYVVDLKT ETVAPPVSVR AYLSQTIIEF KQLISKSVDL LPDTMRVVLE
760 770 780 790 800
RCYNDLRLLN VANKTLKAEG FFRSNKVFVE SSDSLDYQLV FTDSHLWKLL
810 820 830 840 850
DRHANTIRLY VSLPEHTPQT ARSVGPKGGG DSNLSEDYCS RVKGNVKSVD
860 870 880 890 900
AILEESTEKL KSLSLQQHQD GGNGDSSKST EGSDFENIDS PLNEADSGSA
910 920 930 940 950
DNRELENRIL PADPENNFQP EERSDSDVNN DRSTSSVDSD ILSSSHSSDT
960 970 980 990 1000
LCNADSAPIP LANGLDSHSI TSSRRSKAND GKKETWDTAE EDSGTDSEYD
1010 1020 1030 1040 1050
ESGKSRGEAQ YMYFKAEPHA GEGCLGEGNK CLLVSVDKRI TLAAFKQQLE
1060 1070 1080 1090 1100
SFVGVSSSQF KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK
1110 1120 1130 1140 1150
GEYRVKIFQL LVNEPEPCKF LLDAVFSKGM TVRQSKEELL PLLRDQCGLD
1160 1170 1180 1190 1200
LSIDRFRLRK KTWKNPGTVF LDYHVYENES ISSSWEVFLE ALDETEKMKS
1210 1220 1230 1240 1250
MSQLSLFTKR WRPSELKLDP FKEIVMESNS VDELRDKICD ISAIPLENLE
1260 1270 1280 1290 1300
FAKGRGTFPC DISVLEIHQD LDWNPKVSTL NAWPLYISDD GAVIFYRDKM
1310 1320 1330 1340 1350
EELVELTDEQ RNDLAKKESS RLQKTGHRVT YSPRKEKALK IYLDGPSNKD

SSQD
Length:1,354
Mass (Da):153,719
Last modified:January 23, 2007 - v1
Checksum:iE59BABE209E22310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128636 mRNA. Translation: AAI28637.1.
RefSeqiNP_001090710.1. NM_001097241.1.
UniGeneiStr.45630.

Genome annotation databases

GeneIDi100036690.
KEGGixtr:100036690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128636 mRNA. Translation: AAI28637.1 .
RefSeqi NP_001090710.1. NM_001097241.1.
UniGenei Str.45630.

3D structure databases

ProteinModelPortali A1A5G2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000029972.

Protein family/group databases

MEROPSi C19.055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100036690.
KEGGi xtr:100036690.

Organism-specific databases

CTDi 55031.
Xenbasei XB-GENE-5760041. usp47.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000037524.
HOVERGENi HBG058854.
InParanoidi A1A5G2.
KOi K11857.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUBP47_XENTR
AccessioniPrimary (citable) accession number: A1A5G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3