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A1A5G2

- UBP47_XENTR

UniProt

A1A5G2 - UBP47_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene
usp47
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831Nucleophile By similarity
Active sitei488 – 4881Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. base-excision repair Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. monoubiquitinated protein deubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene namesi
Name:usp47
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5760041. usp47.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13541354Ubiquitin carboxyl-terminal hydrolase 47PRO_0000408359Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000029972.

Structurei

3D structure databases

ProteinModelPortaliA1A5G2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 549376USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000037524.
HOVERGENiHBG058854.
KOiK11857.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5G2-1 [UniParc]FASTAAdd to Basket

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MRPGEESHLV PKEIENAADE PRVLCIVQDT TSCKNINERI TLNLPASTSV     50
KQLYEDVSSK AGYVSGTFSL MWGNGASNMV DMAALDPTPD RTLQEAGFEA 100
GKKNFLHLTD KNGEQPQLAS DESGTADSSG LDDSTQEKFI GPLPREESVA 150
CTSDYVSQNY SYSSLLSKSD TGYVGLVNQA MTCYLNSLLQ TLFMTPEFRN 200
ALYKWEFEES EEDPVSSIPY QLQRLFVLLQ TSKKRAIETT DVTRSFGWDS 250
SEAWQQHDVQ ELCRVMFDAL EQKWKQTEQA DLINQLYQGK LKDYVKCLEC 300
GYESWRIDTF LDIPLVIRPF GSNTAFGSME EALQAFIQPE TLDGPNQYFC 350
ERCKRKCDAR KGLKFLHFPY LLTLQLKRFD FDYTSMHRIK LNDRMTFPDE 400
LDMSPFIDVE DEKSPQTDSC TDSGAENEGS CHSDQMSNDF STDDAVDEGI 450
CLETNSNIEK LNKSVSEKNS LYELFSVMVH SGSAAGGHYY ACIKSFADGQ 500
WYSFNDQHVS RITQEDIKKT YGGSTGNRGY YSSAFASSTN AYMLMYRLKN 550
PARNAKFPEA IEFPEHIKLL VQKEQEQEEQ EKRQREIERN TCKLKLFCMH 600
PVKQIMMESK LEVHKDKTMK EAVEIAHKLM DLEGVISLDC CRLVKYDEFH 650
DYLERSYEDE EDRTMGYLLG GVKSSYMFDL LLETKRSDQV FQSYKPGEVM 700
VKVYVVDLKT ETVAPPVSVR AYLSQTIIEF KQLISKSVDL LPDTMRVVLE 750
RCYNDLRLLN VANKTLKAEG FFRSNKVFVE SSDSLDYQLV FTDSHLWKLL 800
DRHANTIRLY VSLPEHTPQT ARSVGPKGGG DSNLSEDYCS RVKGNVKSVD 850
AILEESTEKL KSLSLQQHQD GGNGDSSKST EGSDFENIDS PLNEADSGSA 900
DNRELENRIL PADPENNFQP EERSDSDVNN DRSTSSVDSD ILSSSHSSDT 950
LCNADSAPIP LANGLDSHSI TSSRRSKAND GKKETWDTAE EDSGTDSEYD 1000
ESGKSRGEAQ YMYFKAEPHA GEGCLGEGNK CLLVSVDKRI TLAAFKQQLE 1050
SFVGVSSSQF KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK 1100
GEYRVKIFQL LVNEPEPCKF LLDAVFSKGM TVRQSKEELL PLLRDQCGLD 1150
LSIDRFRLRK KTWKNPGTVF LDYHVYENES ISSSWEVFLE ALDETEKMKS 1200
MSQLSLFTKR WRPSELKLDP FKEIVMESNS VDELRDKICD ISAIPLENLE 1250
FAKGRGTFPC DISVLEIHQD LDWNPKVSTL NAWPLYISDD GAVIFYRDKM 1300
EELVELTDEQ RNDLAKKESS RLQKTGHRVT YSPRKEKALK IYLDGPSNKD 1350
SSQD 1354
Length:1,354
Mass (Da):153,719
Last modified:January 23, 2007 - v1
Checksum:iE59BABE209E22310
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128636 mRNA. Translation: AAI28637.1.
RefSeqiNP_001090710.1. NM_001097241.1.
UniGeneiStr.45630.

Genome annotation databases

GeneIDi100036690.
KEGGixtr:100036690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128636 mRNA. Translation: AAI28637.1 .
RefSeqi NP_001090710.1. NM_001097241.1.
UniGenei Str.45630.

3D structure databases

ProteinModelPortali A1A5G2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000029972.

Protein family/group databases

MEROPSi C19.055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100036690.
KEGGi xtr:100036690.

Organism-specific databases

CTDi 55031.
Xenbasei XB-GENE-5760041. usp47.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000037524.
HOVERGENi HBG058854.
KOi K11857.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUBP47_XENTR
AccessioniPrimary (citable) accession number: A1A5G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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