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A1A5D9 (BICR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bicaudal D-related protein 2

Short name=BICD-related protein 2
Short name=BICDR-2
Alternative name(s):
Coiled-coil domain-containing protein 64B
Gene names
Name:CCDC64B
Synonyms:BICDR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with RAB13 By similarity.

Sequence similarities

Belongs to the BICDR family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A1A5D9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A1A5D9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Bicaudal D-related protein 2
PRO_0000302861

Regions

Coiled coil64 – 300237 Potential
Coiled coil353 – 458106 Potential

Natural variations

Alternative sequence1 – 207207Missing in isoform 2.
VSP_027976
Natural variant551Q → E. Ref.3
Corresponds to variant rs7204908 [ dbSNP | Ensembl ].
VAR_060543
Natural variant2731Q → R. Ref.1 Ref.3
Corresponds to variant rs2244494 [ dbSNP | Ensembl ].
VAR_034978

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 3, 2009. Version 2.
Checksum: A3E6222CF0B2473E

FASTA50856,834
        10         20         30         40         50         60 
MSSPDGPSFP SGPLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL ALQLQQKEKD 

        70         80         90        100        110        120 
LLLAAELGKM LLERNEELRR QLETLSAQHL EREERLQQEN HELRRGLAAR GAEWEARAVE 

       130        140        150        160        170        180 
LEGDVEALRA QLGEQRSEQQ DSGRERARAL SELSEQNLRL SQQLAQASQT EQELQRELDA 

       190        200        210        220        230        240 
LRGQCQAQAL AGAELRTRLE SLQGENQMLQ SRRQDLEAQI RGLREEVEKG EGRLQTTHEE 

       250        260        270        280        290        300 
LLLLRRERRE HSLELERARS EAGEALSALR RLQRRVSELE EESRLQDADV SAASLQSELA 

       310        320        330        340        350        360 
HSLDDGDQGQ GADAPGDTPT TRSPKTRKAS SPQPSPPEEI LEPPKKRTSL SPAEILEEKE 

       370        380        390        400        410        420 
VEVAKLQDEI SLQQAELQSL REELQRQKEL RAQEDPGEAL HSALSDRDEA VNKALELSLQ 

       430        440        450        460        470        480 
LNRVSLERDS LSRELLRAIR QKVALTQELE AWQDDMQVVI GQQLRSQRQK ELSASASSST 

       490        500 
PRRAAPRFSL RLGPGPAGGF LSNLFRRT 

« Hide

Isoform 2 [UniParc].

Checksum: 0EB157962DD3BEA7
Show »

FASTA30133,860

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-273.
Tissue: Stomach.
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-55 AND ARG-273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL833749 mRNA. Translation: CAH56245.1.
AC108134 Genomic DNA. No translation available.
BC128602 mRNA. Translation: AAI28603.1.
RefSeqNP_001096645.1. NM_001103175.1.
XP_005255192.1. XM_005255135.2.
UniGeneHs.513285.

3D structure databases

ProteinModelPortalA1A5D9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126987. 1 interaction.
STRING9606.ENSP00000373998.

PTM databases

PhosphoSiteA1A5D9.

Proteomic databases

PaxDbA1A5D9.
PRIDEA1A5D9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389347; ENSP00000373998; ENSG00000162069. [A1A5D9-1]
ENST00000572449; ENSP00000459043; ENSG00000162069. [A1A5D9-1]
ENST00000573514; ENSP00000461724; ENSG00000162069. [A1A5D9-2]
GeneID146439.
KEGGhsa:146439.
UCSCuc002cte.4. human. [A1A5D9-1]

Organism-specific databases

CTD146439.
GeneCardsGC16M003080.
H-InvDBHIX0012754.
HIX0027051.
HGNCHGNC:33584. CCDC64B.
HPAHPA043251.
neXtProtNX_A1A5D9.
PharmGKBPA162381686.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG119169.
HOGENOMHOG000015285.
HOVERGENHBG107609.
InParanoidA1A5D9.
KOK16756.
OMAGRLQATH.
OrthoDBEOG7KSX8N.
PhylomeDBA1A5D9.
TreeFamTF326671.

Gene expression databases

BgeeA1A5D9.
CleanExHS_CCDC64B.
GenevestigatorA1A5D9.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi146439.
NextBio85363.
PROA1A5D9.

Entry information

Entry nameBICR2_HUMAN
AccessionPrimary (citable) accession number: A1A5D9
Secondary accession number(s): Q658L9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 3, 2009
Last modified: April 16, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM