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A1A5D9

- BICR2_HUMAN

UniProt

A1A5D9 - BICR2_HUMAN

Protein

Bicaudal D-related protein 2

Gene

CCDC64B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bicaudal D-related protein 2
    Short name:
    BICD-related protein 2
    Short name:
    BICDR-2
    Alternative name(s):
    Coiled-coil domain-containing protein 64B
    Gene namesi
    Name:CCDC64B
    Synonyms:BICDR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:33584. CCDC64B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162381686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Bicaudal D-related protein 2PRO_0000302861Add
    BLAST

    Proteomic databases

    PaxDbiA1A5D9.
    PRIDEiA1A5D9.

    PTM databases

    PhosphoSiteiA1A5D9.

    Expressioni

    Gene expression databases

    BgeeiA1A5D9.
    CleanExiHS_CCDC64B.
    GenevestigatoriA1A5D9.

    Organism-specific databases

    HPAiHPA043251.

    Interactioni

    Subunit structurei

    Interacts with RAB13.By similarity

    Protein-protein interaction databases

    BioGridi126987. 1 interaction.
    STRINGi9606.ENSP00000373998.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A5D9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili64 – 300237Sequence AnalysisAdd
    BLAST
    Coiled coili353 – 458106Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BICDR family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG119169.
    HOGENOMiHOG000015285.
    HOVERGENiHBG107609.
    InParanoidiA1A5D9.
    KOiK16756.
    OMAiGRLQATH.
    OrthoDBiEOG7KSX8N.
    PhylomeDBiA1A5D9.
    TreeFamiTF326671.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A1A5D9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSPDGPSFP SGPLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL    50
    ALQLQQKEKD LLLAAELGKM LLERNEELRR QLETLSAQHL EREERLQQEN 100
    HELRRGLAAR GAEWEARAVE LEGDVEALRA QLGEQRSEQQ DSGRERARAL 150
    SELSEQNLRL SQQLAQASQT EQELQRELDA LRGQCQAQAL AGAELRTRLE 200
    SLQGENQMLQ SRRQDLEAQI RGLREEVEKG EGRLQTTHEE LLLLRRERRE 250
    HSLELERARS EAGEALSALR RLQRRVSELE EESRLQDADV SAASLQSELA 300
    HSLDDGDQGQ GADAPGDTPT TRSPKTRKAS SPQPSPPEEI LEPPKKRTSL 350
    SPAEILEEKE VEVAKLQDEI SLQQAELQSL REELQRQKEL RAQEDPGEAL 400
    HSALSDRDEA VNKALELSLQ LNRVSLERDS LSRELLRAIR QKVALTQELE 450
    AWQDDMQVVI GQQLRSQRQK ELSASASSST PRRAAPRFSL RLGPGPAGGF 500
    LSNLFRRT 508
    Length:508
    Mass (Da):56,834
    Last modified:November 3, 2009 - v2
    Checksum:iA3E6222CF0B2473E
    GO
    Isoform 2 (identifier: A1A5D9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-207: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:301
    Mass (Da):33,860
    Checksum:i0EB157962DD3BEA7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551Q → E.1 Publication
    Corresponds to variant rs7204908 [ dbSNP | Ensembl ].
    VAR_060543
    Natural varianti273 – 2731Q → R.2 Publications
    Corresponds to variant rs2244494 [ dbSNP | Ensembl ].
    VAR_034978

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 207207Missing in isoform 2. 1 PublicationVSP_027976Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833749 mRNA. Translation: CAH56245.1.
    AC108134 Genomic DNA. No translation available.
    BC128602 mRNA. Translation: AAI28603.1.
    CCDSiCCDS45393.1. [A1A5D9-1]
    RefSeqiNP_001096645.1. NM_001103175.1. [A1A5D9-1]
    XP_005255192.1. XM_005255135.2. [A1A5D9-1]
    XP_006720913.1. XM_006720850.1. [A1A5D9-1]
    UniGeneiHs.513285.

    Genome annotation databases

    EnsembliENST00000389347; ENSP00000373998; ENSG00000162069. [A1A5D9-1]
    ENST00000572449; ENSP00000459043; ENSG00000162069. [A1A5D9-1]
    ENST00000573514; ENSP00000461724; ENSG00000162069. [A1A5D9-2]
    GeneIDi146439.
    KEGGihsa:146439.
    UCSCiuc002cte.4. human. [A1A5D9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833749 mRNA. Translation: CAH56245.1 .
    AC108134 Genomic DNA. No translation available.
    BC128602 mRNA. Translation: AAI28603.1 .
    CCDSi CCDS45393.1. [A1A5D9-1 ]
    RefSeqi NP_001096645.1. NM_001103175.1. [A1A5D9-1 ]
    XP_005255192.1. XM_005255135.2. [A1A5D9-1 ]
    XP_006720913.1. XM_006720850.1. [A1A5D9-1 ]
    UniGenei Hs.513285.

    3D structure databases

    ProteinModelPortali A1A5D9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126987. 1 interaction.
    STRINGi 9606.ENSP00000373998.

    PTM databases

    PhosphoSitei A1A5D9.

    Proteomic databases

    PaxDbi A1A5D9.
    PRIDEi A1A5D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000389347 ; ENSP00000373998 ; ENSG00000162069 . [A1A5D9-1 ]
    ENST00000572449 ; ENSP00000459043 ; ENSG00000162069 . [A1A5D9-1 ]
    ENST00000573514 ; ENSP00000461724 ; ENSG00000162069 . [A1A5D9-2 ]
    GeneIDi 146439.
    KEGGi hsa:146439.
    UCSCi uc002cte.4. human. [A1A5D9-1 ]

    Organism-specific databases

    CTDi 146439.
    GeneCardsi GC16M003080.
    H-InvDB HIX0012754.
    HIX0027051.
    HGNCi HGNC:33584. CCDC64B.
    HPAi HPA043251.
    neXtProti NX_A1A5D9.
    PharmGKBi PA162381686.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119169.
    HOGENOMi HOG000015285.
    HOVERGENi HBG107609.
    InParanoidi A1A5D9.
    KOi K16756.
    OMAi GRLQATH.
    OrthoDBi EOG7KSX8N.
    PhylomeDBi A1A5D9.
    TreeFami TF326671.

    Miscellaneous databases

    GenomeRNAii 146439.
    NextBioi 85363.
    PROi A1A5D9.

    Gene expression databases

    Bgeei A1A5D9.
    CleanExi HS_CCDC64B.
    Genevestigatori A1A5D9.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-273.
      Tissue: Stomach.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-55 AND ARG-273.

    Entry informationi

    Entry nameiBICR2_HUMAN
    AccessioniPrimary (citable) accession number: A1A5D9
    Secondary accession number(s): Q658L9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3