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Protein

Bicaudal D-related protein 2

Gene

CCDC64B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Bicaudal D-related protein 2
Short name:
BICD-related protein 2
Short name:
BICDR-2
Alternative name(s):
Coiled-coil domain-containing protein 64B
Gene namesi
Name:CCDC64B
Synonyms:BICDR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:33584. CCDC64B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381686.

Polymorphism and mutation databases

BioMutaiCCDC64B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Bicaudal D-related protein 2PRO_0000302861Add
BLAST

Proteomic databases

PaxDbiA1A5D9.
PRIDEiA1A5D9.

PTM databases

PhosphoSiteiA1A5D9.

Expressioni

Gene expression databases

BgeeiA1A5D9.
CleanExiHS_CCDC64B.
GenevisibleiA1A5D9. HS.

Organism-specific databases

HPAiHPA043251.

Interactioni

Subunit structurei

Interacts with RAB13.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KLC3Q6P5973EBI-10171799,EBI-1643885

Protein-protein interaction databases

BioGridi126987. 2 interactions.
IntActiA1A5D9. 1 interaction.
STRINGi9606.ENSP00000373998.

Structurei

3D structure databases

ProteinModelPortaliA1A5D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili64 – 300237Sequence AnalysisAdd
BLAST
Coiled coili353 – 458106Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the BICDR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG119169.
GeneTreeiENSGT00560000077255.
HOGENOMiHOG000015285.
HOVERGENiHBG107609.
InParanoidiA1A5D9.
KOiK16756.
OMAiGRLQATH.
OrthoDBiEOG7KSX8N.
PhylomeDBiA1A5D9.
TreeFamiTF326671.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A1A5D9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPDGPSFP SGPLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL
60 70 80 90 100
ALQLQQKEKD LLLAAELGKM LLERNEELRR QLETLSAQHL EREERLQQEN
110 120 130 140 150
HELRRGLAAR GAEWEARAVE LEGDVEALRA QLGEQRSEQQ DSGRERARAL
160 170 180 190 200
SELSEQNLRL SQQLAQASQT EQELQRELDA LRGQCQAQAL AGAELRTRLE
210 220 230 240 250
SLQGENQMLQ SRRQDLEAQI RGLREEVEKG EGRLQTTHEE LLLLRRERRE
260 270 280 290 300
HSLELERARS EAGEALSALR RLQRRVSELE EESRLQDADV SAASLQSELA
310 320 330 340 350
HSLDDGDQGQ GADAPGDTPT TRSPKTRKAS SPQPSPPEEI LEPPKKRTSL
360 370 380 390 400
SPAEILEEKE VEVAKLQDEI SLQQAELQSL REELQRQKEL RAQEDPGEAL
410 420 430 440 450
HSALSDRDEA VNKALELSLQ LNRVSLERDS LSRELLRAIR QKVALTQELE
460 470 480 490 500
AWQDDMQVVI GQQLRSQRQK ELSASASSST PRRAAPRFSL RLGPGPAGGF

LSNLFRRT
Length:508
Mass (Da):56,834
Last modified:November 3, 2009 - v2
Checksum:iA3E6222CF0B2473E
GO
Isoform 2 (identifier: A1A5D9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,860
Checksum:i0EB157962DD3BEA7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551Q → E.1 Publication
Corresponds to variant rs7204908 [ dbSNP | Ensembl ].
VAR_060543
Natural varianti273 – 2731Q → R.2 Publications
Corresponds to variant rs2244494 [ dbSNP | Ensembl ].
VAR_034978

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 207207Missing in isoform 2. 1 PublicationVSP_027976Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833749 mRNA. Translation: CAH56245.1.
AC108134 Genomic DNA. No translation available.
BC128602 mRNA. Translation: AAI28603.1.
CCDSiCCDS45393.1. [A1A5D9-1]
RefSeqiNP_001096645.1. NM_001103175.1. [A1A5D9-1]
XP_005255192.1. XM_005255135.3. [A1A5D9-1]
XP_006720913.1. XM_006720850.2. [A1A5D9-1]
UniGeneiHs.513285.

Genome annotation databases

EnsembliENST00000389347; ENSP00000373998; ENSG00000162069.
ENST00000572449; ENSP00000459043; ENSG00000162069.
ENST00000573514; ENSP00000461724; ENSG00000162069. [A1A5D9-2]
GeneIDi146439.
KEGGihsa:146439.
UCSCiuc002cte.4. human. [A1A5D9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833749 mRNA. Translation: CAH56245.1.
AC108134 Genomic DNA. No translation available.
BC128602 mRNA. Translation: AAI28603.1.
CCDSiCCDS45393.1. [A1A5D9-1]
RefSeqiNP_001096645.1. NM_001103175.1. [A1A5D9-1]
XP_005255192.1. XM_005255135.3. [A1A5D9-1]
XP_006720913.1. XM_006720850.2. [A1A5D9-1]
UniGeneiHs.513285.

3D structure databases

ProteinModelPortaliA1A5D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126987. 2 interactions.
IntActiA1A5D9. 1 interaction.
STRINGi9606.ENSP00000373998.

PTM databases

PhosphoSiteiA1A5D9.

Polymorphism and mutation databases

BioMutaiCCDC64B.

Proteomic databases

PaxDbiA1A5D9.
PRIDEiA1A5D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389347; ENSP00000373998; ENSG00000162069.
ENST00000572449; ENSP00000459043; ENSG00000162069.
ENST00000573514; ENSP00000461724; ENSG00000162069. [A1A5D9-2]
GeneIDi146439.
KEGGihsa:146439.
UCSCiuc002cte.4. human. [A1A5D9-1]

Organism-specific databases

CTDi146439.
GeneCardsiGC16M003080.
H-InvDBHIX0012754.
HIX0027051.
HGNCiHGNC:33584. CCDC64B.
HPAiHPA043251.
neXtProtiNX_A1A5D9.
PharmGKBiPA162381686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG119169.
GeneTreeiENSGT00560000077255.
HOGENOMiHOG000015285.
HOVERGENiHBG107609.
InParanoidiA1A5D9.
KOiK16756.
OMAiGRLQATH.
OrthoDBiEOG7KSX8N.
PhylomeDBiA1A5D9.
TreeFamiTF326671.

Miscellaneous databases

GenomeRNAii146439.
NextBioi85363.
PROiA1A5D9.

Gene expression databases

BgeeiA1A5D9.
CleanExiHS_CCDC64B.
GenevisibleiA1A5D9. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-273.
    Tissue: Stomach.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-55 AND ARG-273.

Entry informationi

Entry nameiBICR2_HUMAN
AccessioniPrimary (citable) accession number: A1A5D9
Secondary accession number(s): Q658L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 3, 2009
Last modified: July 22, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.