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A1A5D9

- BICR2_HUMAN

UniProt

A1A5D9 - BICR2_HUMAN

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Protein

Bicaudal D-related protein 2

Gene

CCDC64B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Bicaudal D-related protein 2
Short name:
BICD-related protein 2
Short name:
BICDR-2
Alternative name(s):
Coiled-coil domain-containing protein 64B
Gene namesi
Name:CCDC64B
Synonyms:BICDR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:33584. CCDC64B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Bicaudal D-related protein 2PRO_0000302861Add
BLAST

Proteomic databases

PaxDbiA1A5D9.
PRIDEiA1A5D9.

PTM databases

PhosphoSiteiA1A5D9.

Expressioni

Gene expression databases

BgeeiA1A5D9.
CleanExiHS_CCDC64B.
GenevestigatoriA1A5D9.

Organism-specific databases

HPAiHPA043251.

Interactioni

Subunit structurei

Interacts with RAB13.By similarity

Protein-protein interaction databases

BioGridi126987. 1 interaction.
STRINGi9606.ENSP00000373998.

Structurei

3D structure databases

ProteinModelPortaliA1A5D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili64 – 300237Sequence AnalysisAdd
BLAST
Coiled coili353 – 458106Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the BICDR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG119169.
GeneTreeiENSGT00560000077255.
HOGENOMiHOG000015285.
HOVERGENiHBG107609.
InParanoidiA1A5D9.
KOiK16756.
OMAiGRLQATH.
OrthoDBiEOG7KSX8N.
PhylomeDBiA1A5D9.
TreeFamiTF326671.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A1A5D9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPDGPSFP SGPLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL
60 70 80 90 100
ALQLQQKEKD LLLAAELGKM LLERNEELRR QLETLSAQHL EREERLQQEN
110 120 130 140 150
HELRRGLAAR GAEWEARAVE LEGDVEALRA QLGEQRSEQQ DSGRERARAL
160 170 180 190 200
SELSEQNLRL SQQLAQASQT EQELQRELDA LRGQCQAQAL AGAELRTRLE
210 220 230 240 250
SLQGENQMLQ SRRQDLEAQI RGLREEVEKG EGRLQTTHEE LLLLRRERRE
260 270 280 290 300
HSLELERARS EAGEALSALR RLQRRVSELE EESRLQDADV SAASLQSELA
310 320 330 340 350
HSLDDGDQGQ GADAPGDTPT TRSPKTRKAS SPQPSPPEEI LEPPKKRTSL
360 370 380 390 400
SPAEILEEKE VEVAKLQDEI SLQQAELQSL REELQRQKEL RAQEDPGEAL
410 420 430 440 450
HSALSDRDEA VNKALELSLQ LNRVSLERDS LSRELLRAIR QKVALTQELE
460 470 480 490 500
AWQDDMQVVI GQQLRSQRQK ELSASASSST PRRAAPRFSL RLGPGPAGGF

LSNLFRRT
Length:508
Mass (Da):56,834
Last modified:November 3, 2009 - v2
Checksum:iA3E6222CF0B2473E
GO
Isoform 2 (identifier: A1A5D9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.

Note: No experimental confirmation available.

Show »
Length:301
Mass (Da):33,860
Checksum:i0EB157962DD3BEA7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551Q → E.1 Publication
Corresponds to variant rs7204908 [ dbSNP | Ensembl ].
VAR_060543
Natural varianti273 – 2731Q → R.2 Publications
Corresponds to variant rs2244494 [ dbSNP | Ensembl ].
VAR_034978

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 207207Missing in isoform 2. 1 PublicationVSP_027976Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833749 mRNA. Translation: CAH56245.1.
AC108134 Genomic DNA. No translation available.
BC128602 mRNA. Translation: AAI28603.1.
CCDSiCCDS45393.1. [A1A5D9-1]
RefSeqiNP_001096645.1. NM_001103175.1. [A1A5D9-1]
XP_005255192.1. XM_005255135.2. [A1A5D9-1]
XP_006720913.1. XM_006720850.1. [A1A5D9-1]
UniGeneiHs.513285.

Genome annotation databases

EnsembliENST00000389347; ENSP00000373998; ENSG00000162069. [A1A5D9-1]
ENST00000572449; ENSP00000459043; ENSG00000162069. [A1A5D9-1]
ENST00000573514; ENSP00000461724; ENSG00000162069. [A1A5D9-2]
GeneIDi146439.
KEGGihsa:146439.
UCSCiuc002cte.4. human. [A1A5D9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833749 mRNA. Translation: CAH56245.1 .
AC108134 Genomic DNA. No translation available.
BC128602 mRNA. Translation: AAI28603.1 .
CCDSi CCDS45393.1. [A1A5D9-1 ]
RefSeqi NP_001096645.1. NM_001103175.1. [A1A5D9-1 ]
XP_005255192.1. XM_005255135.2. [A1A5D9-1 ]
XP_006720913.1. XM_006720850.1. [A1A5D9-1 ]
UniGenei Hs.513285.

3D structure databases

ProteinModelPortali A1A5D9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126987. 1 interaction.
STRINGi 9606.ENSP00000373998.

PTM databases

PhosphoSitei A1A5D9.

Proteomic databases

PaxDbi A1A5D9.
PRIDEi A1A5D9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389347 ; ENSP00000373998 ; ENSG00000162069 . [A1A5D9-1 ]
ENST00000572449 ; ENSP00000459043 ; ENSG00000162069 . [A1A5D9-1 ]
ENST00000573514 ; ENSP00000461724 ; ENSG00000162069 . [A1A5D9-2 ]
GeneIDi 146439.
KEGGi hsa:146439.
UCSCi uc002cte.4. human. [A1A5D9-1 ]

Organism-specific databases

CTDi 146439.
GeneCardsi GC16M003080.
H-InvDB HIX0012754.
HIX0027051.
HGNCi HGNC:33584. CCDC64B.
HPAi HPA043251.
neXtProti NX_A1A5D9.
PharmGKBi PA162381686.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG119169.
GeneTreei ENSGT00560000077255.
HOGENOMi HOG000015285.
HOVERGENi HBG107609.
InParanoidi A1A5D9.
KOi K16756.
OMAi GRLQATH.
OrthoDBi EOG7KSX8N.
PhylomeDBi A1A5D9.
TreeFami TF326671.

Miscellaneous databases

GenomeRNAii 146439.
NextBioi 85363.
PROi A1A5D9.

Gene expression databases

Bgeei A1A5D9.
CleanExi HS_CCDC64B.
Genevestigatori A1A5D9.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-273.
    Tissue: Stomach.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-55 AND ARG-273.

Entry informationi

Entry nameiBICR2_HUMAN
AccessioniPrimary (citable) accession number: A1A5D9
Secondary accession number(s): Q658L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3