Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1A5C7 (S22AN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 23
Gene names
Name:SLC22A23
Synonyms:C6orf85
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Sequence caution

The sequence BAD18753.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI12303.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI40959.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A1A5C7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A1A5C7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
Isoform 3 (identifier: A1A5C7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: A1A5C7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     362-686: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 686686Solute carrier family 22 member 23
PRO_0000308315

Regions

Transmembrane234 – 25421Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane344 – 36421Helical; Potential
Transmembrane467 – 48721Helical; Potential
Transmembrane494 – 51421Helical; Potential
Transmembrane538 – 55821Helical; Potential
Transmembrane569 – 58921Helical; Potential
Transmembrane598 – 61821Helical; Potential

Amino acid modifications

Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 370370Missing in isoform 3.
VSP_028955
Alternative sequence1 – 281281Missing in isoform 2.
VSP_028954
Alternative sequence362 – 686325Missing in isoform 4.
VSP_028956

Experimental info

Sequence conflict6851A → G in BAD18753. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 035E53BA5FEDF8F0

FASTA68673,748
        10         20         30         40         50         60 
MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI QPLPPLHPGG 

        70         80         90        100        110        120 
GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV LLTWIPALFI GFSQFSDSFL 

       130        140        150        160        170        180 
LDQPNFWCRG AGKGTELAGV TTTGRGGDMG NWTSLPTTPF ATAPWEAAGN RSNSSGADGG 

       190        200        210        220        230        240 
DTPPLPSPPD KGDNASNCDC RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL 

       250        260        270        280        290        300 
IFGYLITGCI ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT 

       310        320        330        340        350        360 
LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII CPFLLMLLYW 

       370        380        390        400        410        420 
SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG VIPELEKELS RRPKKVCIVK 

       430        440        450        460        470        480 
VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR SMMGHEVKVP LLENFYADYY TTASIALVSC 

       490        500        510        520        530        540 
LAMCVVVRFL GRRGGLLLFM ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF 

       550        560        570        580        590        600 
SIVGMFASHA VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH 

       610        620        630        640        650        660 
HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP LLLTNAELKD 

       670        680 
YSGLHDAAAA GDTLPEGATA NGMKAM 

« Hide

Isoform 2 [UniParc].

Checksum: BCC8C2E7604B01AB
Show »

FASTA40544,784
Isoform 3 [UniParc].

Checksum: 6425832AE65DB2D5
Show »

FASTA31634,575
Isoform 4 [UniParc].

Checksum: AAA34339879322DC
Show »

FASTA36138,049

References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-686 (ISOFORM 4).
Tissue: Ovary.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-686.
Tissue: Colon.
[4]"Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family."
Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.
Genomics 90:595-609(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL160398, AL445309 Genomic DNA. Translation: CAI12303.1. Sequence problems.
AL445309, AL160398 Genomic DNA. Translation: CAI40959.1. Sequence problems.
BC040876 mRNA. Translation: AAH40876.1.
BC128580 mRNA. Translation: AAI28581.1.
BC128581 mRNA. Translation: AAI28582.1.
AK172770 mRNA. Translation: BAD18753.1. Different initiation.
RefSeqNP_001273384.1. NM_001286455.1.
NP_001273385.1. NM_001286456.1.
NP_056297.1. NM_015482.1.
NP_068764.3. NM_021945.6.
UniGeneHs.713588.

3D structure databases

ProteinModelPortalA1A5C7.
SMRA1A5C7. Positions 235-383, 473-501, 557-586, 596-629.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121960. 1 interaction.

Protein family/group databases

TCDB2.A.1.19.28. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteA1A5C7.

Proteomic databases

PaxDbA1A5C7.
PRIDEA1A5C7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380298; ENSP00000369653; ENSG00000137266. [A1A5C7-4]
ENST00000380302; ENSP00000369657; ENSG00000137266. [A1A5C7-2]
ENST00000406686; ENSP00000385028; ENSG00000137266. [A1A5C7-1]
ENST00000490273; ENSP00000419463; ENSG00000137266. [A1A5C7-2]
GeneID63027.
KEGGhsa:63027.
UCSCuc003mvm.3. human. [A1A5C7-1]

Organism-specific databases

CTD63027.
GeneCardsGC06M003269.
H-InvDBHIX0005541.
HIX0005544.
HGNCHGNC:21106. SLC22A23.
HPAHPA014697.
MIM611697. gene.
neXtProtNX_A1A5C7.
PharmGKBPA162403516.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG275019.
HOGENOMHOG000124569.
HOVERGENHBG108437.
InParanoidA1A5C7.
KOK08215.
PhylomeDBA1A5C7.
TreeFamTF335753.

Gene expression databases

ArrayExpressA1A5C7.
BgeeA1A5C7.
CleanExHS_SLC22A23.
GenevestigatorA1A5C7.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi63027.
NextBio65527.
PROA1A5C7.
SOURCESearch...

Entry information

Entry nameS22AN_HUMAN
AccessionPrimary (citable) accession number: A1A5C7
Secondary accession number(s): A1A5C8 expand/collapse secondary AC list , Q5T8B8, Q6ZMH3, Q8IW73
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM