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A1A5C7

- S22AN_HUMAN

UniProt

A1A5C7 - S22AN_HUMAN

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Protein

Solute carrier family 22 member 23

Gene

SLC22A23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.19.28. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 23
Gene namesi
Name:SLC22A23
Synonyms:C6orf85
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21106. SLC22A23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST
Transmembranei494 – 51421HelicalSequence AnalysisAdd
BLAST
Transmembranei538 – 55821HelicalSequence AnalysisAdd
BLAST
Transmembranei569 – 58921HelicalSequence AnalysisAdd
BLAST
Transmembranei598 – 61821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Solute carrier family 22 member 23PRO_0000308315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1A5C7.
PRIDEiA1A5C7.

PTM databases

PhosphoSiteiA1A5C7.

Expressioni

Gene expression databases

BgeeiA1A5C7.
CleanExiHS_SLC22A23.
ExpressionAtlasiA1A5C7. baseline and differential.
GenevestigatoriA1A5C7.

Organism-specific databases

HPAiHPA014697.

Interactioni

Protein-protein interaction databases

BioGridi121960. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliA1A5C7.
SMRiA1A5C7. Positions 235-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275019.
GeneTreeiENSGT00390000014377.
HOGENOMiHOG000124569.
HOVERGENiHBG108437.
InParanoidiA1A5C7.
KOiK08215.
PhylomeDBiA1A5C7.
TreeFamiTF335753.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A1A5C7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI
60 70 80 90 100
QPLPPLHPGG GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV
110 120 130 140 150
LLTWIPALFI GFSQFSDSFL LDQPNFWCRG AGKGTELAGV TTTGRGGDMG
160 170 180 190 200
NWTSLPTTPF ATAPWEAAGN RSNSSGADGG DTPPLPSPPD KGDNASNCDC
210 220 230 240 250
RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL IFGYLITGCI
260 270 280 290 300
ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT
310 320 330 340 350
LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII
360 370 380 390 400
CPFLLMLLYW SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG
410 420 430 440 450
VIPELEKELS RRPKKVCIVK VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR
460 470 480 490 500
SMMGHEVKVP LLENFYADYY TTASIALVSC LAMCVVVRFL GRRGGLLLFM
510 520 530 540 550
ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF SIVGMFASHA
560 570 580 590 600
VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH
610 620 630 640 650
HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP
660 670 680
LLLTNAELKD YSGLHDAAAA GDTLPEGATA NGMKAM
Length:686
Mass (Da):73,748
Last modified:October 23, 2007 - v2
Checksum:i035E53BA5FEDF8F0
GO
Isoform 2 (identifier: A1A5C7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Show »
Length:405
Mass (Da):44,784
Checksum:iBCC8C2E7604B01AB
GO
Isoform 3 (identifier: A1A5C7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.

Note: No experimental confirmation available.

Show »
Length:316
Mass (Da):34,575
Checksum:i6425832AE65DB2D5
GO
Isoform 4 (identifier: A1A5C7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-686: Missing.

Note: No experimental confirmation available.

Show »
Length:361
Mass (Da):38,049
Checksum:iAAA34339879322DC
GO

Sequence cautioni

The sequence BAD18753.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI12303.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40959.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti685 – 6851A → G in BAD18753. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 370370Missing in isoform 3. 1 PublicationVSP_028955Add
BLAST
Alternative sequencei1 – 281281Missing in isoform 2. 1 PublicationVSP_028954Add
BLAST
Alternative sequencei362 – 686325Missing in isoform 4. 1 PublicationVSP_028956Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160398, AL445309 Genomic DNA. Translation: CAI12303.1. Sequence problems.
AL445309, AL160398 Genomic DNA. Translation: CAI40959.1. Sequence problems.
BC040876 mRNA. Translation: AAH40876.1.
BC128580 mRNA. Translation: AAI28581.1.
BC128581 mRNA. Translation: AAI28582.1.
AK172770 mRNA. Translation: BAD18753.1. Different initiation.
CCDSiCCDS34331.1. [A1A5C7-2]
CCDS47363.1. [A1A5C7-1]
CCDS75389.1. [A1A5C7-4]
RefSeqiNP_001273384.1. NM_001286455.1. [A1A5C7-2]
NP_001273385.1. NM_001286456.1. [A1A5C7-4]
NP_056297.1. NM_015482.1. [A1A5C7-1]
NP_068764.3. NM_021945.6. [A1A5C7-2]
UniGeneiHs.713588.

Genome annotation databases

EnsembliENST00000380298; ENSP00000369653; ENSG00000137266. [A1A5C7-4]
ENST00000380302; ENSP00000369657; ENSG00000137266. [A1A5C7-2]
ENST00000406686; ENSP00000385028; ENSG00000137266. [A1A5C7-1]
ENST00000490273; ENSP00000419463; ENSG00000137266. [A1A5C7-2]
GeneIDi63027.
KEGGihsa:63027.
UCSCiuc003mvm.3. human. [A1A5C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160398 , AL445309 Genomic DNA. Translation: CAI12303.1 . Sequence problems.
AL445309 , AL160398 Genomic DNA. Translation: CAI40959.1 . Sequence problems.
BC040876 mRNA. Translation: AAH40876.1 .
BC128580 mRNA. Translation: AAI28581.1 .
BC128581 mRNA. Translation: AAI28582.1 .
AK172770 mRNA. Translation: BAD18753.1 . Different initiation.
CCDSi CCDS34331.1. [A1A5C7-2 ]
CCDS47363.1. [A1A5C7-1 ]
CCDS75389.1. [A1A5C7-4 ]
RefSeqi NP_001273384.1. NM_001286455.1. [A1A5C7-2 ]
NP_001273385.1. NM_001286456.1. [A1A5C7-4 ]
NP_056297.1. NM_015482.1. [A1A5C7-1 ]
NP_068764.3. NM_021945.6. [A1A5C7-2 ]
UniGenei Hs.713588.

3D structure databases

ProteinModelPortali A1A5C7.
SMRi A1A5C7. Positions 235-383.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121960. 2 interactions.

Protein family/group databases

TCDBi 2.A.1.19.28. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei A1A5C7.

Proteomic databases

PaxDbi A1A5C7.
PRIDEi A1A5C7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380298 ; ENSP00000369653 ; ENSG00000137266 . [A1A5C7-4 ]
ENST00000380302 ; ENSP00000369657 ; ENSG00000137266 . [A1A5C7-2 ]
ENST00000406686 ; ENSP00000385028 ; ENSG00000137266 . [A1A5C7-1 ]
ENST00000490273 ; ENSP00000419463 ; ENSG00000137266 . [A1A5C7-2 ]
GeneIDi 63027.
KEGGi hsa:63027.
UCSCi uc003mvm.3. human. [A1A5C7-1 ]

Organism-specific databases

CTDi 63027.
GeneCardsi GC06M003269.
H-InvDB HIX0005541.
HIX0005544.
HGNCi HGNC:21106. SLC22A23.
HPAi HPA014697.
MIMi 611697. gene.
neXtProti NX_A1A5C7.
PharmGKBi PA162403516.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275019.
GeneTreei ENSGT00390000014377.
HOGENOMi HOG000124569.
HOVERGENi HBG108437.
InParanoidi A1A5C7.
KOi K08215.
PhylomeDBi A1A5C7.
TreeFami TF335753.

Miscellaneous databases

ChiTaRSi SLC22A23. human.
GenomeRNAii 63027.
NextBioi 65527.
PROi A1A5C7.
SOURCEi Search...

Gene expression databases

Bgeei A1A5C7.
CleanExi HS_SLC22A23.
ExpressionAtlasi A1A5C7. baseline and differential.
Genevestigatori A1A5C7.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-686 (ISOFORM 4).
    Tissue: Ovary.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-686.
    Tissue: Colon.
  4. "Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family."
    Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.
    Genomics 90:595-609(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS22AN_HUMAN
AccessioniPrimary (citable) accession number: A1A5C7
Secondary accession number(s): A1A5C8
, Q5T8B8, Q6ZMH3, Q8IW73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3