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Protein

TBC1 domain family member 25

Gene

Tbc1d25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 25
Gene namesi
Name:Tbc1d25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2444862. Tbc1d25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885091 – 742TBC1 domain family member 25Add BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1
Modified residuei214PhosphothreonineCombined sources1
Modified residuei560PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA1A5B6.
MaxQBiA1A5B6.
PaxDbiA1A5B6.
PeptideAtlasiA1A5B6.
PRIDEiA1A5B6.

PTM databases

iPTMnetiA1A5B6.
PhosphoSitePlusiA1A5B6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039201.
CleanExiMM_TBC1D25.
ExpressionAtlasiA1A5B6. baseline and differential.
GenevisibleiA1A5B6. MM.

Interactioni

Subunit structurei

Interacts (via N-terminus) with MAP1LC3B, GABARAP and GABARAPL2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047838.

Structurei

3D structure databases

ProteinModelPortaliA1A5B6.
SMRiA1A5B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini282 – 488Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST207

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 81Poly-Ala6
Compositional biasi83 – 88Poly-Glu6
Compositional biasi529 – 533Poly-Gly5
Compositional biasi596 – 662Pro-richAdd BLAST67

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2197. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00550000074386.
HOGENOMiHOG000039975.
HOVERGENiHBG103222.
InParanoidiA1A5B6.
OMAiEHRDHIM.
OrthoDBiEOG091G036C.
PhylomeDBiA1A5B6.
TreeFamiTF323518.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 3 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPAQARWE GQGPTAPLRL RSGARWGRGR PHCWVYVRVR VTIGYHLDRD
60 70 80 90 100
DSGGMATTSA ASDSACSAAP PPVGGAQAAA AVEEEEREVV RVRVKKCESF
110 120 130 140 150
LSPEFRSFAV DPQITSLDVL QHILIRAFDL NGKKNFGISY LARDRLGQET
160 170 180 190 200
FLSLLSDWDL STAFATASKP YLQLRVDIRP SEDSPLLEDW DIISPKDVIG
210 220 230 240 250
SDVLLAEKRS SLTTAALPFT QSILSQVGRT LSKVQQVLSW SYGEDVKPFK
260 270 280 290 300
PPLSDAEFHT YLNHEGQLSR PEELRLRIYH GGVEPSLRKV VWRYLLNVYP
310 320 330 340 350
DGLTGRERMD YMKRKSREYE QLKSEWAQRV NPEDLEFIRS TVLKDVLRTD
360 370 380 390 400
RAHPYYAGPE DGPHLRALHD LLTTYAVTHP QVSYCQGMSD LASPILAVMD
410 420 430 440 450
HEGHAFVCFC GIMKRLAANF HPDGRAMATK FAHLKLLLRH ADPDFYQYLQ
460 470 480 490 500
EAGADDLFFC YRWLLLELKR EFAFDDALRM LEVTWSSLPP DPPEHEVELV
510 520 530 540 550
GPPSQVADTG FGSHRGRPVR QRHMLRPAGG GGGAFEDAVV HLAASSQGPS
560 570 580 590 600
GGGRLLRQAS LDGLQQLRDN MGLRKDHLVQ LSHPATLISS KSLSEPLLNS
610 620 630 640 650
PDPLLSTSSR PDSPSSSSPP STQEASPSGD IAVGSPLMQE VGSPRDPGKP
660 670 680 690 700
VPPPPPMGLP PPQEFGRGNP FMLFLCLAIL LEHRDHIMRN GLDYNELAMH
710 720 730 740
FDRLVRKHHL GRVLRRAKAL FADYLQSEVW DSEEGAEATA PS
Length:742
Mass (Da):82,575
Last modified:January 23, 2007 - v1
Checksum:iF1CD1A40BDB46F47
GO

Sequence cautioni

The sequence BAC30751 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115T → A in BAC37146 (PubMed:16141072).Curated1
Sequence conflicti626S → Y in BAC30751 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040932 mRNA. Translation: BAC30751.1. Different initiation.
AK078145 mRNA. Translation: BAC37146.1.
AL663032 Genomic DNA. Translation: CAM19502.1.
BC128566 mRNA. Translation: AAI28567.1.
CCDSiCCDS29988.1.
RefSeqiNP_001159909.1. NM_001166437.1.
NP_766066.2. NM_172478.3.
UniGeneiMm.122963.

Genome annotation databases

EnsembliENSMUST00000039892; ENSMUSP00000047838; ENSMUSG00000039201.
GeneIDi209815.
KEGGimmu:209815.
UCSCiuc009sog.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040932 mRNA. Translation: BAC30751.1. Different initiation.
AK078145 mRNA. Translation: BAC37146.1.
AL663032 Genomic DNA. Translation: CAM19502.1.
BC128566 mRNA. Translation: AAI28567.1.
CCDSiCCDS29988.1.
RefSeqiNP_001159909.1. NM_001166437.1.
NP_766066.2. NM_172478.3.
UniGeneiMm.122963.

3D structure databases

ProteinModelPortaliA1A5B6.
SMRiA1A5B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047838.

PTM databases

iPTMnetiA1A5B6.
PhosphoSitePlusiA1A5B6.

Proteomic databases

EPDiA1A5B6.
MaxQBiA1A5B6.
PaxDbiA1A5B6.
PeptideAtlasiA1A5B6.
PRIDEiA1A5B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039892; ENSMUSP00000047838; ENSMUSG00000039201.
GeneIDi209815.
KEGGimmu:209815.
UCSCiuc009sog.2. mouse.

Organism-specific databases

CTDi4943.
MGIiMGI:2444862. Tbc1d25.

Phylogenomic databases

eggNOGiKOG2197. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00550000074386.
HOGENOMiHOG000039975.
HOVERGENiHBG103222.
InParanoidiA1A5B6.
OMAiEHRDHIM.
OrthoDBiEOG091G036C.
PhylomeDBiA1A5B6.
TreeFamiTF323518.

Miscellaneous databases

PROiA1A5B6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039201.
CleanExiMM_TBC1D25.
ExpressionAtlasiA1A5B6. baseline and differential.
GenevisibleiA1A5B6. MM.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 3 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC25_MOUSE
AccessioniPrimary (citable) accession number: A1A5B6
Secondary accession number(s): Q8BIM6, Q8BIW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.