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Protein
Submitted name:

KIAA0999 protein

Gene

KIAA0999

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiA1A5A9.

Names & Taxonomyi

Protein namesi
Submitted name:
KIAA0999 proteinImported
Gene namesi
Name:KIAA0999Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

EPDiA1A5A9.
PaxDbiA1A5A9.

Expressioni

Gene expression databases

BgeeiA1A5A9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000292055.

Chemistry

BindingDBiA1A5A9.

Structurei

3D structure databases

ProteinModelPortaliA1A5A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 158158Protein kinaseInterPro annotationAdd
BLAST
Domaini185 – 22541UBAInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili482 – 50928Sequence analysisAdd
BLAST
Coiled coili777 – 79923Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOVERGENiHBG079682.
KOiK19009.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A5A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEARRKF KQIVTAVYFC HCRNIVHRDL KAENLLLDAN LNIKIADFGF
60 70 80 90 100
SNLFTPGQLL KTWCGSPPYA APELFEGKEY DGPKVDIWSL GVVLYVLVCG
110 120 130 140 150
ALPFDGSTLQ NLRARVLSGK FRIPFFMSTE CEHLIRHMLV LDPNKRLSME
160 170 180 190 200
QICKHKWMKL GDADPNFDRL IAECQQLKEE RQVDPLNEDV LLAMEDMGLD
210 220 230 240 250
KEQTLQSLRS DAYDHYSAIY SLLCDRHKRH KTLRLGALPS MPRALAFQAP
260 270 280 290 300
VNIQAEQAGT AMNISVPQVQ LINPENQIVE PDGTLNLDSD EGEEPSPEAL
310 320 330 340 350
VRYLSMRRHT VGVADPRTEV MEDLQKLLPG FPGVNPQAPF LQVAPNVNFM
360 370 380 390 400
HNLLPMQNLQ PTGQLEYKEQ SLLQPPTLQL LNGMGPLGRR ASDGGANIQL
410 420 430 440 450
HAQQLLKRPR GPSPLVTMTP AVPAVTPVDE ESSDGEPDQE AVQSSTYKDS
460 470 480 490 500
NTLHLPTERF SPVRRFSDGA ASIQAFKAHL EKMGNNSSIK QLQQECEQLQ
510 520 530 540 550
KMYGGQIDER TLEKTQQQHM LYQQEQHHQI LQQQIQDSIC PPQPSPPLQA
560 570 580 590 600
ACENQPALLT HQLQRLRIQP SSPPPNHPNN HLFRQPSNSP PPMSSAMIQP
610 620 630 640 650
HGAASSSQFQ GLPSRSAIFQ QQPENCSSPP NVALTCLGMQ QPAQSQQVTI
660 670 680 690 700
QVQEPVDMLS NMPGTAAGSS GRGISISPSA GQMQMQHRTN LMATLSYGHR
710 720 730 740 750
PLSKQLSADS AEAHSAHQQP PHYTTSALQQ ALLSPTPPDY TRHQQVPHIL
760 770 780 790 800
QGLLSPRHSL TGHSDIRLPP TEFAQLIKRQ QQQRQQQQQQ QQQQEYQELF
810 820 830 840 850
RHMNQGDAGS LAPSLGGQSM TERQALSYQN ADSYHHHTSP QHLLQIRAQE
860 870 880 890 900
CVSQASSPTP PHGYAHQPAL MHSESMEEDC SCEGAKDGFQ DSKSSSTLTK
910 920 930 940 950
GCHDSPLLLS TGGPGDPESL LGTVSHAQEL GIHPYGHQPT AAFSKNKVPS
960 970 980 990 1000
REPVIGNCMD RSSPGQAVEL PDHNGLGYPA RPSVHEHHRP RALQRHHTIQ
1010 1020 1030 1040 1050
NSDDAYVQLD NLPGMSLVAG KALSSARMSD AVLSQSSLMG SQQFQDGENE
1060 1070 1080 1090 1100
ECGASLGGHE HPDLSDGSQH LNSSCYPSTC ITDILLSYKH PEVSFSMEQA

GV
Length:1,102
Mass (Da):121,747
Last modified:January 23, 2007 - v1
Checksum:i9761B08C90131E4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128511 mRNA. Translation: AAI28512.1.
RefSeqiNP_001268677.1. NM_001281748.1.
UniGeneiHs.167451.

Genome annotation databases

GeneIDi23387.
KEGGihsa:23387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128511 mRNA. Translation: AAI28512.1.
RefSeqiNP_001268677.1. NM_001281748.1.
UniGeneiHs.167451.

3D structure databases

ProteinModelPortaliA1A5A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000292055.

Chemistry

BindingDBiA1A5A9.

Proteomic databases

EPDiA1A5A9.
PaxDbiA1A5A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23387.
KEGGihsa:23387.

Organism-specific databases

CTDi23387.
HUGEiSearch...

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOVERGENiHBG079682.
KOiK19009.

Enzyme and pathway databases

SignaLinkiA1A5A9.

Miscellaneous databases

ChiTaRSiSIK3. human.
GenomeRNAii23387.
NextBioi35460343.

Gene expression databases

BgeeiA1A5A9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiA1A5A9_HUMAN
AccessioniPrimary (citable) accession number: A1A5A9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.