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Protein

Keratin-associated protein 23-1

Gene

KRTAP23-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 23-1
Gene namesi
Name:KRTAP23-1
Synonyms:KAP23.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18928. KRTAP23-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978709.

Polymorphism and mutation databases

BioMutaiKRTAP23-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Keratin-associated protein 23-1PRO_0000290066Add
BLAST

Proteomic databases

PaxDbiA1A580.
PeptideAtlasiA1A580.
PRIDEiA1A580.

Expressioni

Gene expression databases

CleanExiHS_KRTAP23-1.

Organism-specific databases

HPAiHPA017945.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-10171734,EBI-711810
RBPMSQ930623EBI-10171734,EBI-740322

Protein-protein interaction databases

BioGridi130646. 3 interactions.
IntActiA1A580. 3 interactions.
STRINGi9606.ENSP00000346536.

Structurei

3D structure databases

ProteinModelPortaliA1A580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JJWC. Eukaryota.
ENOG4111BQ3. LUCA.
GeneTreeiENSGT00390000012229.
HOGENOMiHOG000113251.
InParanoidiA1A580.
OMAiCGGYLCY.
OrthoDBiEOG79SF1Q.
PhylomeDBiA1A580.
TreeFamiTF341533.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNCCCGNF SSHSCEGYLC YSGYSRGGSS YPSNLVYSTE PLISQHLPAG
60
FLSLQGLSGD LLGNP
Length:65
Mass (Da):6,892
Last modified:January 23, 2007 - v1
Checksum:i306C2057359CD049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128435 mRNA. Translation: AAI28436.1.
CCDSiCCDS33533.1.
RefSeqiNP_853655.1. NM_181624.1.
UniGeneiHs.553688.

Genome annotation databases

EnsembliENST00000334160; ENSP00000346536; ENSG00000186980.
GeneIDi337963.
KEGGihsa:337963.
UCSCiuc002yny.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128435 mRNA. Translation: AAI28436.1.
CCDSiCCDS33533.1.
RefSeqiNP_853655.1. NM_181624.1.
UniGeneiHs.553688.

3D structure databases

ProteinModelPortaliA1A580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130646. 3 interactions.
IntActiA1A580. 3 interactions.
STRINGi9606.ENSP00000346536.

Polymorphism and mutation databases

BioMutaiKRTAP23-1.

Proteomic databases

PaxDbiA1A580.
PeptideAtlasiA1A580.
PRIDEiA1A580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334160; ENSP00000346536; ENSG00000186980.
GeneIDi337963.
KEGGihsa:337963.
UCSCiuc002yny.2. human.

Organism-specific databases

CTDi337963.
GeneCardsiKRTAP23-1.
HGNCiHGNC:18928. KRTAP23-1.
HPAiHPA017945.
neXtProtiNX_A1A580.
PharmGKBiPA134978709.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JJWC. Eukaryota.
ENOG4111BQ3. LUCA.
GeneTreeiENSGT00390000012229.
HOGENOMiHOG000113251.
InParanoidiA1A580.
OMAiCGGYLCY.
OrthoDBiEOG79SF1Q.
PhylomeDBiA1A580.
TreeFamiTF341533.

Miscellaneous databases

GenomeRNAii337963.
PROiA1A580.

Gene expression databases

CleanExiHS_KRTAP23-1.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKR231_HUMAN
AccessioniPrimary (citable) accession number: A1A580
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.