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A1A560

- A1A560_MOUSE

UniProt

A1A560 - A1A560_MOUSE

Protein
Submitted name:

IL2-inducible T-cell kinase

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: Ensembl

    GO - Biological processi

    1. interferon-gamma production Source: MGI
    2. interleukin-4 production Source: MGI
    3. intracellular signal transduction Source: InterPro
    4. NK T cell differentiation Source: MGI

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    IL2-inducible T-cell kinaseImported
    Gene namesi
    Name:ItkImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96621. Itk.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiA1A560.
    BgeeiA1A560.
    GenevestigatoriA1A560.

    Structurei

    3D structure databases

    ProteinModelPortaliA1A560.
    SMRiA1A560. Positions 115-229, 231-337, 355-617.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PH domain.
    Contains 1 SH3 domain.UniRule annotation
    Contains PH domain.SAAS annotation
    Contains SH2 domain.SAAS annotation
    Contains SH3 domain.SAAS annotation
    Contains SHdomain.SAAS annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG008761.
    KOiK07363.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view]
    PfamiPF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1A560-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKRTL    50
    KGSIELSRIK CVEIVKSDIS IPCHYKYPFQ VVHDNYLLYV FAPDCESRQR 100
    WVLTLKEETR NNNSLVSKYH PNFWMDGRWR CCSQLEKPAV GCAPYDPSKN 150
    ASKKPLPPTP EDNRRSFQEP EETLVIALYD YQTNDPQELA LRCDEEYYLL 200
    DSSEIHWWRV QDKNGHEGYA PSSYLVEKSP NNLETYEWYN KSISRDKAEK 250
    LLLDTGKEGA FMVRDSRTPG TYTVSVFTKA IISENPCIKH YHIKETNDSP 300
    KRYYVAEKYV FDSIPLLIQY HQYNGGGLVT RLRYPVCSWR QKAPVTAGLR 350
    YGKWVIQPSE LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED 400
    FIEEAEVMMK LSHPKLVQLY GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG 450
    LFAAETLLGM CLDVCEGMAY LEKACVIHRD LAARNCLVGE NQVIKVSDFG 500
    MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW SFGVLMWEVF 550
    SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASCHVYQIMN HCWKEKPEDR 600
    PPFSQLLSQL AEIAEAGL 618
    Length:618
    Mass (Da):71,446
    Last modified:January 23, 2007 - v1
    Checksum:i30E940B26E3B0268
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128375 mRNA. Translation: AAI28376.1.
    RefSeqiNP_001268897.1. NM_001281968.1.
    UniGeneiMm.339927.

    Genome annotation databases

    GeneIDi16428.
    KEGGimmu:16428.
    UCSCiuc011xtm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC128375 mRNA. Translation: AAI28376.1 .
    RefSeqi NP_001268897.1. NM_001281968.1.
    UniGenei Mm.339927.

    3D structure databases

    ProteinModelPortali A1A560.
    SMRi A1A560. Positions 115-229, 231-337, 355-617.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16428.
    KEGGi mmu:16428.
    UCSCi uc011xtm.1. mouse.

    Organism-specific databases

    CTDi 3702.
    MGIi MGI:96621. Itk.

    Phylogenomic databases

    HOVERGENi HBG008761.
    KOi K07363.

    Miscellaneous databases

    NextBioi 35542344.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A1A560.
    Bgeei A1A560.
    Genevestigatori A1A560.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view ]
    Pfami PF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.

    Entry informationi

    Entry nameiA1A560_MOUSE
    AccessioniPrimary (citable) accession number: A1A560
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)