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A1A560

- A1A560_MOUSE

UniProt

A1A560 - A1A560_MOUSE

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Protein
Submitted name:

IL2-inducible T-cell kinase

Gene
Itk
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: Ensembl

GO - Biological processi

  1. interferon-gamma production Source: MGI
  2. interleukin-4 production Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. NK T cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
IL2-inducible T-cell kinaseImported
Gene namesi
Name:ItkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96621. Itk.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiA1A560.
BgeeiA1A560.
GenevestigatoriA1A560.

Structurei

3D structure databases

ProteinModelPortaliA1A560.
SMRiA1A560. Positions 115-229, 231-337, 355-617.

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 SH3 domain.UniRule annotation
Contains PH domain.SAAS annotations
Contains SH2 domain.SAAS annotations
Contains SH3 domain.SAAS annotations
Contains SHdomain.SAAS annotations
Contains protein kinase domain.SAAS annotations

Keywords - Domaini

SH2 domainSAAS annotations, SH3 domainUniRule annotationSAAS annotations

Phylogenomic databases

HOVERGENiHBG008761.
KOiK07363.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A560-1 [UniParc]FASTAAdd to Basket

« Hide

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKRTL    50
KGSIELSRIK CVEIVKSDIS IPCHYKYPFQ VVHDNYLLYV FAPDCESRQR 100
WVLTLKEETR NNNSLVSKYH PNFWMDGRWR CCSQLEKPAV GCAPYDPSKN 150
ASKKPLPPTP EDNRRSFQEP EETLVIALYD YQTNDPQELA LRCDEEYYLL 200
DSSEIHWWRV QDKNGHEGYA PSSYLVEKSP NNLETYEWYN KSISRDKAEK 250
LLLDTGKEGA FMVRDSRTPG TYTVSVFTKA IISENPCIKH YHIKETNDSP 300
KRYYVAEKYV FDSIPLLIQY HQYNGGGLVT RLRYPVCSWR QKAPVTAGLR 350
YGKWVIQPSE LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED 400
FIEEAEVMMK LSHPKLVQLY GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG 450
LFAAETLLGM CLDVCEGMAY LEKACVIHRD LAARNCLVGE NQVIKVSDFG 500
MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW SFGVLMWEVF 550
SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASCHVYQIMN HCWKEKPEDR 600
PPFSQLLSQL AEIAEAGL 618
Length:618
Mass (Da):71,446
Last modified:January 23, 2007 - v1
Checksum:i30E940B26E3B0268
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128375 mRNA. Translation: AAI28376.1.
RefSeqiNP_001268897.1. NM_001281968.1.
UniGeneiMm.339927.

Genome annotation databases

GeneIDi16428.
KEGGimmu:16428.
UCSCiuc011xtm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC128375 mRNA. Translation: AAI28376.1 .
RefSeqi NP_001268897.1. NM_001281968.1.
UniGenei Mm.339927.

3D structure databases

ProteinModelPortali A1A560.
SMRi A1A560. Positions 115-229, 231-337, 355-617.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16428.
KEGGi mmu:16428.
UCSCi uc011xtm.1. mouse.

Organism-specific databases

CTDi 3702.
MGIi MGI:96621. Itk.

Phylogenomic databases

HOVERGENi HBG008761.
KOi K07363.

Miscellaneous databases

NextBioi 35542344.
SOURCEi Search...

Gene expression databases

ArrayExpressi A1A560.
Bgeei A1A560.
Genevestigatori A1A560.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view ]
Pfami PF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTi SM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiA1A560_MOUSE
AccessioniPrimary (citable) accession number: A1A560
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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