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A1A560 (A1A560_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
IL2-inducible T-cell kinase EMBL AAI28376.1
Gene names
Name:Itk MGI 96621
OrganismMus musculus (Mouse) EMBL AAI28376.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266

Sequence similarities

Contains 1 PH domain. RuleBase RU003350

Contains 1 SH2 domain. SAAS SAAS008266

Contains 1 SH3 domain. RuleBase RU003338 SAAS SAAS008266

Contains 1 protein kinase domain. SAAS SAAS008266

Sequences

Sequence LengthMass (Da)Tools
A1A560 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 30E940B26E3B0268

FASTA61871,446
        10         20         30         40         50         60 
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKRTL KGSIELSRIK 

        70         80         90        100        110        120 
CVEIVKSDIS IPCHYKYPFQ VVHDNYLLYV FAPDCESRQR WVLTLKEETR NNNSLVSKYH 

       130        140        150        160        170        180 
PNFWMDGRWR CCSQLEKPAV GCAPYDPSKN ASKKPLPPTP EDNRRSFQEP EETLVIALYD 

       190        200        210        220        230        240 
YQTNDPQELA LRCDEEYYLL DSSEIHWWRV QDKNGHEGYA PSSYLVEKSP NNLETYEWYN 

       250        260        270        280        290        300 
KSISRDKAEK LLLDTGKEGA FMVRDSRTPG TYTVSVFTKA IISENPCIKH YHIKETNDSP 

       310        320        330        340        350        360 
KRYYVAEKYV FDSIPLLIQY HQYNGGGLVT RLRYPVCSWR QKAPVTAGLR YGKWVIQPSE 

       370        380        390        400        410        420 
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 

       430        440        450        460        470        480 
GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFAAETLLGM CLDVCEGMAY LEKACVIHRD 

       490        500        510        520        530        540 
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 

       550        560        570        580        590        600 
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASCHVYQIMN HCWKEKPEDR 

       610 
PPFSQLLSQL AEIAEAGL

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PCR rescued clones EMBL AAI28376.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC128375 mRNA. Translation: AAI28376.1.
IPIIPI00856373.
UniGeneMm.339927.

3D structure databases

ProteinModelPortalA1A560.
SMRA1A560. Positions 115-229, 231-337, 355-617.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1A560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc011xtm.1. mouse.

Organism-specific databases

MGIMGI:96621. Itk.

Phylogenomic databases

HOVERGENHBG008761.

Gene expression databases

ArrayExpressA1A560.
BgeeA1A560.
GenevestigatorA1A560.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35542344.
SOURCESearch...

Entry information

Entry nameA1A560_MOUSE
AccessionPrimary (citable) accession number: A1A560
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info