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A1A560

- A1A560_MOUSE

UniProt

A1A560 - A1A560_MOUSE

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Protein
Submitted name:

IL2-inducible T-cell kinase

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. interferon-gamma production Source: MGI
  2. interleukin-4 production Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. NK T cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
IL2-inducible T-cell kinaseImported
Gene namesi
Name:ItkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96621. Itk.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Expressioni

Gene expression databases

BgeeiA1A560.
ExpressionAtlasiA1A560. baseline and differential.
GenevestigatoriA1A560.

Structurei

3D structure databases

ProteinModelPortaliA1A560.
SMRiA1A560. Positions 115-229, 231-337, 355-617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains PH domain.SAAS annotation
Contains SH2 domain.SAAS annotation
Contains SH3 domain.SAAS annotation
Contains SHdomain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG008761.
KOiK07363.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A560-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKRTL
60 70 80 90 100
KGSIELSRIK CVEIVKSDIS IPCHYKYPFQ VVHDNYLLYV FAPDCESRQR
110 120 130 140 150
WVLTLKEETR NNNSLVSKYH PNFWMDGRWR CCSQLEKPAV GCAPYDPSKN
160 170 180 190 200
ASKKPLPPTP EDNRRSFQEP EETLVIALYD YQTNDPQELA LRCDEEYYLL
210 220 230 240 250
DSSEIHWWRV QDKNGHEGYA PSSYLVEKSP NNLETYEWYN KSISRDKAEK
260 270 280 290 300
LLLDTGKEGA FMVRDSRTPG TYTVSVFTKA IISENPCIKH YHIKETNDSP
310 320 330 340 350
KRYYVAEKYV FDSIPLLIQY HQYNGGGLVT RLRYPVCSWR QKAPVTAGLR
360 370 380 390 400
YGKWVIQPSE LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED
410 420 430 440 450
FIEEAEVMMK LSHPKLVQLY GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG
460 470 480 490 500
LFAAETLLGM CLDVCEGMAY LEKACVIHRD LAARNCLVGE NQVIKVSDFG
510 520 530 540 550
MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW SFGVLMWEVF
560 570 580 590 600
SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASCHVYQIMN HCWKEKPEDR
610
PPFSQLLSQL AEIAEAGL
Length:618
Mass (Da):71,446
Last modified:January 23, 2007 - v1
Checksum:i30E940B26E3B0268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128375 mRNA. Translation: AAI28376.1.
RefSeqiNP_001268897.1. NM_001281968.1.
UniGeneiMm.339927.

Genome annotation databases

GeneIDi16428.
KEGGimmu:16428.
UCSCiuc011xtm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128375 mRNA. Translation: AAI28376.1 .
RefSeqi NP_001268897.1. NM_001281968.1.
UniGenei Mm.339927.

3D structure databases

ProteinModelPortali A1A560.
SMRi A1A560. Positions 115-229, 231-337, 355-617.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16428.
KEGGi mmu:16428.
UCSCi uc011xtm.1. mouse.

Organism-specific databases

CTDi 3702.
MGIi MGI:96621. Itk.

Phylogenomic databases

HOVERGENi HBG008761.
KOi K07363.

Miscellaneous databases

NextBioi 35542344.
SOURCEi Search...

Gene expression databases

Bgeei A1A560.
ExpressionAtlasi A1A560. baseline and differential.
Genevestigatori A1A560.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view ]
Pfami PF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTi SM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiA1A560_MOUSE
AccessioniPrimary (citable) accession number: A1A560
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)