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Protein
Submitted name:

Transcription factor 3

Gene

Tcf7l1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi343 – 411HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-4641265 Repression of WNT target genes
R-MMU-8951430 RUNX3 regulates WNT signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 3Imported
Submitted name:
Transcription factor 7-like 1Imported
Gene namesi
Name:Tcf7l1Imported
Synonyms:Tcf3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1202876 Tcf7l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000055799

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini343 – 411HMG boxInterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00390000009964
HOGENOMiHOG000116032
HOVERGENiHBG000419
KOiK04490
TreeFamiTF318448

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028773 TCF7L
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF25 PTHR10373:SF25, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1A550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLGGGRGG GAGGGGGGSG AGATSGGDDL GANDELIPFQ DEGGEEQEPS
60 70 80 90 100
SDSASAQRDL DEVKSSLVNE SENQSSSSDS EAERRPQPAR DAFQKPRDYF
110 120 130 140 150
AEVRRPQDGA FFKGPAYPGY PFLMIPDLSS PYLSNGPLSP GGARTYLQMK
160 170 180 190 200
WPLLDVPSSA TVKDTRSPSP AHLSNKVPVV QHPHHMHPLT PLITYSNDHF
210 220 230 240 250
SPASPPTHLS PEIDPKTGIP RPPHPSELSP YYPLSPGAVG QIPHPLGWLV
260 270 280 290 300
PQQGQPMYSL PPGGFRHPYP ALAMNASMSS LVSSRFPHMV APAHPGLPTS
310 320 330 340 350
GIPHPAIVSP IVKQEPAAPS LSPAVSAKSP VTVKKEEEKK PHVKKPLNAF
360 370 380 390 400
MLYMKEMRAK VVAECTLKES AAINQILGRK WHNLSREEQA KYYELARKER
410 420 430 440 450
QLHAQLYPTW SARDNYGKKK KRKREKQLSQ TQSQQQIQEA EGALASKSKK
460 470 480 490 500
PCIQYLPPEK PCDSPASSHG STLDSPATPS AALASPAAPA ATHSEQAQPL
510 520 530 540 550
SLTTKPEARA QLALHSAAFL SAKAAASNSS QMGSQPPLLS RPLPLGSMPA
560 570 580
ALLTSPPTFP ATLHAHQALP VLQAQPLSLV TKSAH
Length:585
Mass (Da):62,412
Last modified:January 23, 2007 - v1
Checksum:i7D30494F693A7EEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125039 Genomic DNA No translation available.
AC153613 Genomic DNA No translation available.
BC128306 mRNA Translation: AAI28307.1
RefSeqiNP_033358.2, NM_009332.3
UniGeneiMm.440067

Genome annotation databases

EnsembliENSMUST00000069536; ENSMUSP00000069403; ENSMUSG00000055799
GeneIDi21415
KEGGimmu:21415
UCSCiuc009cja.2 mouse

Similar proteinsi

Entry informationi

Entry nameiA1A550_MOUSE
AccessioniPrimary (citable) accession number: A1A550
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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