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Protein
Submitted name:

Transcription factor 3

Gene

Tcf7l1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi343 – 411HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 3Imported
Submitted name:
Transcription factor 7-like 1Imported
Gene namesi
Name:Tcf7l1Imported
Synonyms:Tcf3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1202876. Tcf7l1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000055799.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109687.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini343 – 411HMG box DNA-bindingInterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG3248. Eukaryota.
ENOG41109RU. LUCA.
GeneTreeiENSGT00390000009964.
HOGENOMiHOG000116032.
HOVERGENiHBG000419.
KOiK04490.
TreeFamiTF318448.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028778. Tcf7l1.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF41. PTHR10373:SF41. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1A550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLGGGRGG GAGGGGGGSG AGATSGGDDL GANDELIPFQ DEGGEEQEPS
60 70 80 90 100
SDSASAQRDL DEVKSSLVNE SENQSSSSDS EAERRPQPAR DAFQKPRDYF
110 120 130 140 150
AEVRRPQDGA FFKGPAYPGY PFLMIPDLSS PYLSNGPLSP GGARTYLQMK
160 170 180 190 200
WPLLDVPSSA TVKDTRSPSP AHLSNKVPVV QHPHHMHPLT PLITYSNDHF
210 220 230 240 250
SPASPPTHLS PEIDPKTGIP RPPHPSELSP YYPLSPGAVG QIPHPLGWLV
260 270 280 290 300
PQQGQPMYSL PPGGFRHPYP ALAMNASMSS LVSSRFPHMV APAHPGLPTS
310 320 330 340 350
GIPHPAIVSP IVKQEPAAPS LSPAVSAKSP VTVKKEEEKK PHVKKPLNAF
360 370 380 390 400
MLYMKEMRAK VVAECTLKES AAINQILGRK WHNLSREEQA KYYELARKER
410 420 430 440 450
QLHAQLYPTW SARDNYGKKK KRKREKQLSQ TQSQQQIQEA EGALASKSKK
460 470 480 490 500
PCIQYLPPEK PCDSPASSHG STLDSPATPS AALASPAAPA ATHSEQAQPL
510 520 530 540 550
SLTTKPEARA QLALHSAAFL SAKAAASNSS QMGSQPPLLS RPLPLGSMPA
560 570 580
ALLTSPPTFP ATLHAHQALP VLQAQPLSLV TKSAH
Length:585
Mass (Da):62,412
Last modified:January 23, 2007 - v1
Checksum:i7D30494F693A7EEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125039 Genomic DNA. No translation available.
AC153613 Genomic DNA. No translation available.
BC128306 mRNA. Translation: AAI28307.1.
RefSeqiNP_033358.2. NM_009332.3.
UniGeneiMm.440067.

Genome annotation databases

EnsembliENSMUST00000069536; ENSMUSP00000069403; ENSMUSG00000055799.
GeneIDi21415.
KEGGimmu:21415.
UCSCiuc009cja.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125039 Genomic DNA. No translation available.
AC153613 Genomic DNA. No translation available.
BC128306 mRNA. Translation: AAI28307.1.
RefSeqiNP_033358.2. NM_009332.3.
UniGeneiMm.440067.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069536; ENSMUSP00000069403; ENSMUSG00000055799.
GeneIDi21415.
KEGGimmu:21415.
UCSCiuc009cja.2. mouse.

Organism-specific databases

CTDi83439.
MGIiMGI:1202876. Tcf7l1.

Phylogenomic databases

eggNOGiKOG3248. Eukaryota.
ENOG41109RU. LUCA.
GeneTreeiENSGT00390000009964.
HOGENOMiHOG000116032.
HOVERGENiHBG000419.
KOiK04490.
TreeFamiTF318448.

Miscellaneous databases

ChiTaRSiTcf7l1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055799.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR024940. TCF/LEF.
IPR028778. Tcf7l1.
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF41. PTHR10373:SF41. 1 hit.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1A550_MOUSE
AccessioniPrimary (citable) accession number: A1A550
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.