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Protein

Peptidoglycan recognition protein 3

Gene

Pglyrp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei237 – 2371MureinBy similarity
Binding sitei248 – 2481MureinBy similarity

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-positive bacterium Source: MGI
  • detection of bacterium Source: MGI
  • growth of symbiont in host Source: MGI
  • innate immune response Source: UniProtKB-KW
  • negative regulation of interferon-gamma production Source: MGI
  • negative regulation of natural killer cell differentiation involved in immune response Source: MGI
  • pattern recognition receptor signaling pathway Source: MGI
  • peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 3
Alternative name(s):
Peptidoglycan recognition protein I-alpha
Short name:
PGLYRPIalpha
Short name:
PGRP-I-alpha
Peptidoglycan recognition protein intermediate alpha
Gene namesi
Name:Pglyrp3
Synonyms:Gm420, Pgrpia
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2685266. Pglyrp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 347321Peptidoglycan recognition protein 3PRO_0000295274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi184 ↔ 306By similarity
Disulfide bondi200 ↔ 244By similarity
Disulfide bondi220 ↔ 226By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA1A547.
PRIDEiA1A547.

PTM databases

PhosphoSiteiA1A547.

Expressioni

Tissue specificityi

Detected in lung, spleen and stomach, and at low levels in eye, heart, thymus and testis.1 Publication

Gene expression databases

BgeeiA1A547.
CleanExiMM_PGLYRP3.

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035737.

Structurei

3D structure databases

ProteinModelPortaliA1A547.
SMRiA1A547. Positions 28-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni270 – 2756Interaction with mureinBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000267017.
HOVERGENiHBG053579.
InParanoidiA1A547.
KOiK01446.
OMAiHTYGFND.
OrthoDBiEOG757CZ5.
TreeFamiTF323898.

Family and domain databases

Gene3Di3.40.80.10. 2 hits.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 2 hits.
[Graphical view]
SMARTiSM00644. Ami_2. 2 hits.
SM00701. PGRP. 2 hits.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1A547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVSWDHPKM LPRLLGFLAL SLLACGNPTI VSRKEWGASS LTCRVPLSLP
60 70 80 90 100
VPYLIIEQVT RMQCQDQITC SQVVRVLQSQ YVHNKGWCDI AFNFLVGDDG
110 120 130 140 150
KVYEGVGWYV QGLHTQGYNN VSLGIAFFGS KIGSPSPAAL SATEDLIFFA
160 170 180 190 200
IQNGYLSPKY IQPFLLKEET CLVPQHSEIP KKACPNITPR SAWEARETHC
210 220 230 240 250
PQMNLPAKFV IIIHTAGKSC NESADCLVRV RDTQSFHIDN QDFCDIAYHF
260 270 280 290 300
LVGQDGEVYE GVGWNIEGSH TYGYNDIALG IAFMGNFVEK PPNEASLKAA
310 320 330 340
QSLIQCAVAK GYLTSNYLLM GHSDVSNILS PGQALYNIIK TWPHFKH
Length:347
Mass (Da):38,503
Last modified:July 27, 2011 - v2
Checksum:i1AAEF71374B66F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491F → S in AAS49172 (PubMed:15177568).Curated
Sequence conflicti155 – 1551Y → H in AAS49172 (PubMed:15177568).Curated
Sequence conflicti161 – 1611I → T in AAS49172 (PubMed:15177568).Curated
Sequence conflicti232 – 2321D → G in AAS49172 (PubMed:15177568).Curated
Sequence conflicti232 – 2321D → G in AAI28292 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518698 mRNA. Translation: AAS49172.1.
AC163215 Genomic DNA. No translation available.
BC128291 mRNA. Translation: AAI28292.1.
CCDSiCCDS17545.1.
RefSeqiNP_997130.2. NM_207247.4.
XP_006501535.1. XM_006501472.2.
XP_006501536.1. XM_006501473.2.
UniGeneiMm.297406.

Genome annotation databases

EnsembliENSMUST00000047660; ENSMUSP00000035737; ENSMUSG00000042244.
GeneIDi242100.
KEGGimmu:242100.
UCSCiuc008qdi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518698 mRNA. Translation: AAS49172.1.
AC163215 Genomic DNA. No translation available.
BC128291 mRNA. Translation: AAI28292.1.
CCDSiCCDS17545.1.
RefSeqiNP_997130.2. NM_207247.4.
XP_006501535.1. XM_006501472.2.
XP_006501536.1. XM_006501473.2.
UniGeneiMm.297406.

3D structure databases

ProteinModelPortaliA1A547.
SMRiA1A547. Positions 28-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035737.

PTM databases

PhosphoSiteiA1A547.

Proteomic databases

PaxDbiA1A547.
PRIDEiA1A547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047660; ENSMUSP00000035737; ENSMUSG00000042244.
GeneIDi242100.
KEGGimmu:242100.
UCSCiuc008qdi.2. mouse.

Organism-specific databases

CTDi114771.
MGIiMGI:2685266. Pglyrp3.

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000267017.
HOVERGENiHBG053579.
InParanoidiA1A547.
KOiK01446.
OMAiHTYGFND.
OrthoDBiEOG757CZ5.
TreeFamiTF323898.

Miscellaneous databases

NextBioi385231.
PROiA1A547.
SOURCEiSearch...

Gene expression databases

BgeeiA1A547.
CleanExiMM_PGLYRP3.

Family and domain databases

Gene3Di3.40.80.10. 2 hits.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 2 hits.
[Graphical view]
SMARTiSM00644. Ami_2. 2 hits.
SM00701. PGRP. 2 hits.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine peptidoglycan recognition proteins PglyrpIalpha and PglyrpIbeta are encoded in the epidermal differentiation complex and are expressed in epidermal and hematopoietic tissues."
    Mathur P., Murray B., Crowell T., Gardner H., Allaire N., Hsu Y.-M., Thill G., Carulli J.P.
    Genomics 83:1151-1163(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPGRP3_MOUSE
AccessioniPrimary (citable) accession number: A1A547
Secondary accession number(s): E9QMH8, Q6R1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 27, 2011
Last modified: November 11, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.