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A1A515

- A1A515_HUMAN

UniProt

A1A515 - A1A515_HUMAN

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Protein

Fibroblast growth factor

Gene

FGF8

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. fibroblast growth factor receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factorSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:FGF8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliA1A515.
SMRiA1A515. Positions 23-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

HOGENOMiHOG000115986.
HOVERGENiHBG005659.
KOiK04358.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A515-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS
60 70 80 90 100
GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN
110 120 130 140 150
KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK
160 170 180 190 200
GSKTRQHQRE AHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA

PEPR
Length:204
Mass (Da):23,494
Last modified:January 23, 2007 - v1
Checksum:i9A4CAB6524288A90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128236 mRNA. Translation: AAI28237.1.
RefSeqiNP_006110.1. NM_006119.4.
NP_149353.1. NM_033163.3.
NP_149354.1. NM_033164.3.
NP_149355.1. NM_033165.3.
UniGeneiHs.57710.

Genome annotation databases

GeneIDi2253.
KEGGihsa:2253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128236 mRNA. Translation: AAI28237.1 .
RefSeqi NP_006110.1. NM_006119.4.
NP_149353.1. NM_033163.3.
NP_149354.1. NM_033164.3.
NP_149355.1. NM_033165.3.
UniGenei Hs.57710.

3D structure databases

ProteinModelPortali A1A515.
SMRi A1A515. Positions 23-169.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2253.
KEGGi hsa:2253.

Organism-specific databases

CTDi 2253.

Phylogenomic databases

HOGENOMi HOG000115986.
HOVERGENi HBG005659.
KOi K04358.

Miscellaneous databases

GenomeRNAii 2253.
NextBioi 9121.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PRINTSi PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiA1A515_HUMAN
AccessioniPrimary (citable) accession number: A1A515
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.