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Protein

Protein C-ets-2

Gene

ETS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi364 – 444ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:ETS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871311 – 470Protein C-ets-2Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei302PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by CDK10 at Ser-225 may create a phosphodegron that targets ETS2 for proteasomal degradation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1A4L6.
PRIDEiA1A4L6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012144.

Structurei

3D structure databases

ProteinModelPortaliA1A4L6.
SMRiA1A4L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 170PNTPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiA1A4L6.
KOiK21932.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed_sf.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
PIRSFiPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiView protein in SMART
SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiView protein in PROSITE
PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.

Sequencei

Sequence statusi: Complete.

A1A4L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDFGIKNMD QVAPVASSYR GTLKRQAAFD TFDGSLLAVF PSLNEEQTLQ
60 70 80 90 100
EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP
110 120 130 140 150
KNPWLWTEQQ VCQWLLWATN EFSLVDVNLQ RFGMTGQVLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKNEDQYEE NSHLNSVPHW INSNSLGFGV
210 220 230 240 250
EQAPYGMQTQ SYPKGGLLDG LCPASSAPST LGPEQDFQMF PKARLNTVSV
260 270 280 290 300
NYCSVGQDFP AGSLNLLSSA SGKPRDHDSA ETGGDSFESS ESLLQSWNSQ
310 320 330 340 350
SSLLDVQRVP SFESFEDDCS QSLGLSKPTM SFKDYIQDRS DPVEQGKPVI
360 370 380 390 400
PAAVLAGFTG SGPIQLWQFL LELLSDKSCQ SFISWTGDGW EFKLADPDEV
410 420 430 440 450
ARRWGKRKNK PKMNYEKLSR GLRYYYDKNI IHKTSGKRYV YRFVCDLQNL
460 470
LGFTPEELHA ILGVQPDTED
Length:470
Mass (Da):52,654
Last modified:January 23, 2007 - v1
Checksum:iA0F1364B8DACC6AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126692 mRNA. Translation: AAI26693.1.
RefSeqiNP_001073683.1. NM_001080214.1.
UniGeneiBt.103933.
Bt.5774.

Genome annotation databases

GeneIDi281148.
KEGGibta:281148.

Similar proteinsi

Entry informationi

Entry nameiETS2_BOVIN
AccessioniPrimary (citable) accession number: A1A4L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families