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Protein

Sorting nexin-4

Gene

SNX4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei108Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei132Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei154Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:SNX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:35111 SNX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002901841 – 450Sorting nexin-4Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA1A4L0
PRIDEiA1A4L0

Expressioni

Gene expression databases

BgeeiENSBTAG00000011383

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015120

Structurei

3D structure databases

ProteinModelPortaliA1A4L0
SMRiA1A4L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 187PXPROSITE-ProRule annotationAdd BLAST127

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2273 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00910000144107
HOGENOMiHOG000007933
HOVERGENiHBG017826
InParanoidiA1A4L0
KOiK17919
OMAiRYTEFEL
OrthoDBiEOG091G0CLA
TreeFamiTF328543

Family and domain databases

CDDicd07622 BAR_SNX4, 1 hit
cd06864 PX_SNX4, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR034902 PX_SNX4
IPR034783 SNX4
IPR037430 SNX4_BAR
PANTHERiPTHR10555:SF139 PTHR10555:SF139, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

A1A4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQAAPDPER LWQPAPLEPL SHPDAGLESM VGEETKGARD EGPGDGTMTE
60 70 80 90 100
NNFSLKKIEI SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHNDGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRNYLLVY YPHIVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRIGLEN FLLRVASHPI LCRDKIFYLF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF IELKHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELATGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKMLEE QIKEGEQQLK SKNLEGREFV
410 420 430 440 450
RNAWADIERF KEQKNHDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):52,194
Last modified:January 23, 2007 - v1
Checksum:iC02B701A1EE9E606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126650 mRNA Translation: AAI26651.1
RefSeqiNP_001073750.1, NM_001080281.2
UniGeneiBt.7574

Genome annotation databases

EnsembliENSBTAT00000015120; ENSBTAP00000015120; ENSBTAG00000011383
GeneIDi519597
KEGGibta:519597

Similar proteinsi

Entry informationi

Entry nameiSNX4_BOVIN
AccessioniPrimary (citable) accession number: A1A4L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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