Reviewed, UniProtKB/Swiss-Prot A1A4H9 (LRRT1_BOVIN)

Names and origin

Protein names

Recommended name:
    Leucine-rich repeat transmembrane neuronal protein 1

Gene names

Name:

LRRTM1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role during the development of specific forebrain structures by influencing neuronal differentiation and connectivity, with a possible role in intracellular trafficking within axons By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the LRRTM family. Contains 10 LRR (leucine-rich) repeats.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 521	521	Leucine-rich repeat transmembrane neuronal protein 1		PRO_0000317786
	Signal peptide	1 – 34	34	Potential
Regions
	Topological domain	35 – 426	392	Lumenal Potential
	Transmembrane	427 – 447	21	Potential
	Topological domain	448 – 521	74	Cytoplasmic Potential
	Repeat	64 – 87	24	LRR 1
	Repeat	89 – 111	23	LRR 2
	Repeat	112 – 135	24	LRR 3
	Repeat	136 – 159	24	LRR 4
	Repeat	161 – 183	23	LRR 5
	Repeat	184 – 207	24	LRR 6
	Repeat	209 – 231	23	LRR 7
	Repeat	233 – 255	23	LRR 8
	Repeat	256 – 278	23	LRR 9
	Repeat	280 – 302	23	LRR 10
Amino acid modifications
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Glycosylation	380	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A1A4H9-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 2A7440F6B1B8CE28	FASTA	521	58,660
	10 20 30 40 50 60 MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA 70 80 90 100 110 120 PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL 130 140 150 160 170 180 SSNQITQLAN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI 190 200 210 220 230 240 FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL 250 260 270 280 290 300 RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYVEPRIL 310 320 330 340 350 360 NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDGNL QCASPEYAQG EDVLDAVYAF 370 380 390 400 410 420 HLCEEGAEPT SGHLLSAVTN RSDLGFPAGP ATTLADDREG QPDSTPEPVT VALPGEHAEN 430 440 450 460 470 480 AVQIHKVVTG TMALIFSFLI VVLVLYVSWK CFPASLRQLR QCFVTQRRKQ KQKQTMHQMA 490 500 510 520 AMSAQEYYVD YKPNHIEGAL VIINEYGSCT CHQQPARECE V

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.

Web resources

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC126503 mRNA. Translation: AAI26504.1.
IPI	IPI00706066.
RefSeq	NP_001073773.1.
UniGene	Bt.34711
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000003864; ENSBTAP00000003864; ENSBTAG00000002967; Bos taurus. [Genome view]
GeneID	538452.
KEGG	bta:538452.
Organism-specific databases
CTD	538452.
Phylogenomic databases
HOVERGEN	A1A4H9.
InParanoid	A1A4H9.
OMA	INEYGSC.
OrthoDB	EOG98GZP1.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR000372. Leu-rich_rpt_Cys-rich-dom_N. IPR003591. Leu-rich_rpt_typical-subtyp. [Graphical view]
Pfam	PF00560. LRR_1. 5 hits. [Graphical view]
SMART	SM00369. LRR_TYP. 3 hits. SM00013. LRRNT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LRRT1_BOVIN

Accession

Primary (citable) accession number: A1A4H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 23, 2007
Last modified:	December 15, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)