A1A4H9 (LRRT1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat transmembrane neuronal protein 1

Gene names

Name:

LRRTM1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role during the development of specific forebrain structures by influencing neuronal differentiation and connectivity, with a possible role in intracellular trafficking within axons By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the LRRTM family. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Chain	35 – 521	487	Leucine-rich repeat transmembrane neuronal protein 1		PRO_0000317786
Regions
	Topological domain	35 – 426	392	Lumenal Potential
	Transmembrane	427 – 447	21	Helical; Potential
	Topological domain	448 – 521	74	Cytoplasmic Potential
	Domain	35 – 66	32	LRRNT
	Repeat	90 – 111	22	LRR 1
	Repeat	114 – 135	22	LRR 2
	Repeat	138 – 159	22	LRR 3
	Repeat	162 – 183	22	LRR 4
	Repeat	186 – 207	22	LRR 5
	Repeat	210 – 230	21	LRR 6
	Repeat	234 – 255	22	LRR 7
	Repeat	257 – 278	22	LRR 8
	Repeat	281 – 302	22	LRR 9
	Domain	314 – 365	52	LRRCT
Amino acid modifications
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Glycosylation	380	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A1A4H9 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 2A7440F6B1B8CE28	FASTA	521	58,660
	10 20 30 40 50 60 MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA 70 80 90 100 110 120 PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL 130 140 150 160 170 180 SSNQITQLAN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI 190 200 210 220 230 240 FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL 250 260 270 280 290 300 RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYVEPRIL 310 320 330 340 350 360 NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDGNL QCASPEYAQG EDVLDAVYAF 370 380 390 400 410 420 HLCEEGAEPT SGHLLSAVTN RSDLGFPAGP ATTLADDREG QPDSTPEPVT VALPGEHAEN 430 440 450 460 470 480 AVQIHKVVTG TMALIFSFLI VVLVLYVSWK CFPASLRQLR QCFVTQRRKQ KQKQTMHQMA 490 500 510 520 AMSAQEYYVD YKPNHIEGAL VIINEYGSCT CHQQPARECE V

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.

Web resources

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC126503 mRNA. Translation: AAI26504.1.
IPI	IPI00706066.
RefSeq	NP_001073773.1. NM_001080304.1. XP_002691416.1. XM_002691370.1.
UniGene	Bt.34711.
3D structure databases
ProteinModelPortal	A1A4H9.
ModBase	Search...
Proteomic databases
PRIDE	A1A4H9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000003864; ENSBTAP00000003864; ENSBTAG00000002967.
GeneID	538452.
KEGG	bta:538452.
Organism-specific databases
CTD	347730.
Phylogenomic databases
eggNOG	maNOG05298.
GeneTree	ENSGT00600000084202.
HOVERGEN	HBG052362.
InParanoid	A1A4H9.
OMA	AFHLCED.
OrthoDB	EOG4FN4HG.
PhylomeDB	A1A4H9.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF00560. LRR_1. 2 hits. [Graphical view]
SMART	SM00369. LRR_TYP. 3 hits. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 9 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LRRT1_BOVIN

Accession

Primary (citable) accession number: A1A4H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program