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Protein

Leukemia NUP98 fusion partner 1

Gene

LNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia NUP98 fusion partner 1
Gene namesi
Name:LNP1
Synonyms:NP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28014. LNP1.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LNP1 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with NUP98.1 Publication

Organism-specific databases

OpenTargetsiENSG00000206535.
PharmGKBiPA142671542.

Polymorphism and mutation databases

BioMutaiLNP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003413571 – 178Leukemia NUP98 fusion partner 1Add BLAST178

Proteomic databases

MaxQBiA1A4G5.
PaxDbiA1A4G5.
PRIDEiA1A4G5.

PTM databases

iPTMnetiA1A4G5.
PhosphoSitePlusiA1A4G5.

Expressioni

Gene expression databases

BgeeiENSG00000206535.
CleanExiHS_LNP1.
ExpressionAtlasiA1A4G5. baseline and differential.
GenevisibleiA1A4G5. HS.

Organism-specific databases

HPAiHPA047926.

Interactioni

Protein-protein interaction databases

BioGridi131532. 14 interactors.
STRINGi9606.ENSP00000373191.

Structurei

3D structure databases

ProteinModelPortaliA1A4G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 10Poly-Asp6

Phylogenomic databases

eggNOGiENOG410J1GM. Eukaryota.
ENOG410Z4TY. LUCA.
GeneTreeiENSGT00390000007797.
HOVERGENiHBG101586.
InParanoidiA1A4G5.
PhylomeDBiA1A4G5.
TreeFamiTF342726.

Family and domain databases

InterProiView protein in InterPro
IPR029280. LNP1.
PfamiView protein in Pfam
PF15419. LNP1. 1 hit.

Sequencei

Sequence statusi: Complete.

A1A4G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKDDDDDD VSFAKWMSSF WGHSWREEDQ RGLRERHRLQ ATSHRKTSLP
60 70 80 90 100
CPLPVLPRIP SSDCHPRRHS HEDQEFRCRS HVRDYRKYSE DGSFKEPLES
110 120 130 140 150
KGRSHSKIEK FSESFERQLC FRTKRSASLG PESRKERNER ECLRMEIKSR
160 170
KKVEEERSSR KEEHGEAHMA PLFEKGPE
Length:178
Mass (Da):21,321
Last modified:January 23, 2007 - v1
Checksum:iA51126C819511E23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126362 mRNA. Translation: AAI26363.1.
BC130480 mRNA. Translation: AAI30481.1.
BC144031 mRNA. Translation: AAI44032.1.
CCDSiCCDS43120.1.
RefSeqiNP_001078920.1. NM_001085451.1.
UniGeneiHs.591294.

Genome annotation databases

EnsembliENST00000383693; ENSP00000373191; ENSG00000206535.
GeneIDi348801.
KEGGihsa:348801.
UCSCiuc003dtx.5. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiLNP1_HUMAN
AccessioniPrimary (citable) accession number: A1A4G5
Secondary accession number(s): B7ZLT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM