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Protein

Leukemia NUP98 fusion partner 1

Gene

LNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia NUP98 fusion partner 1
Gene namesi
Name:LNP1
Synonyms:NP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28014. LNP1.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LNP1 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with NUP98.

Organism-specific databases

PharmGKBiPA142671542.

Polymorphism and mutation databases

BioMutaiLNP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Leukemia NUP98 fusion partner 1PRO_0000341357Add
BLAST

Proteomic databases

MaxQBiA1A4G5.
PaxDbiA1A4G5.
PRIDEiA1A4G5.

PTM databases

PhosphoSiteiA1A4G5.

Expressioni

Gene expression databases

BgeeiA1A4G5.
CleanExiHS_LNP1.
ExpressionAtlasiA1A4G5. baseline and differential.
GenevisibleiA1A4G5. HS.

Organism-specific databases

HPAiHPA047926.

Interactioni

Protein-protein interaction databases

BioGridi131532. 1 interaction.
STRINGi9606.ENSP00000373191.

Structurei

3D structure databases

ProteinModelPortaliA1A4G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 106Poly-Asp

Phylogenomic databases

eggNOGiENOG410J1GM. Eukaryota.
ENOG410Z4TY. LUCA.
GeneTreeiENSGT00390000007797.
HOVERGENiHBG101586.
InParanoidiA1A4G5.
OrthoDBiEOG77Q4Z5.
PhylomeDBiA1A4G5.
TreeFamiTF342726.

Family and domain databases

InterProiIPR029280. LNP1.
[Graphical view]
PfamiPF15419. LNP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1A4G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKDDDDDD VSFAKWMSSF WGHSWREEDQ RGLRERHRLQ ATSHRKTSLP
60 70 80 90 100
CPLPVLPRIP SSDCHPRRHS HEDQEFRCRS HVRDYRKYSE DGSFKEPLES
110 120 130 140 150
KGRSHSKIEK FSESFERQLC FRTKRSASLG PESRKERNER ECLRMEIKSR
160 170
KKVEEERSSR KEEHGEAHMA PLFEKGPE
Length:178
Mass (Da):21,321
Last modified:January 23, 2007 - v1
Checksum:iA51126C819511E23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126362 mRNA. Translation: AAI26363.1.
BC130480 mRNA. Translation: AAI30481.1.
BC144031 mRNA. Translation: AAI44032.1.
CCDSiCCDS43120.1.
RefSeqiNP_001078920.1. NM_001085451.1.
UniGeneiHs.591294.

Genome annotation databases

EnsembliENST00000383693; ENSP00000373191; ENSG00000206535.
GeneIDi348801.
KEGGihsa:348801.
UCSCiuc003dtx.5. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126362 mRNA. Translation: AAI26363.1.
BC130480 mRNA. Translation: AAI30481.1.
BC144031 mRNA. Translation: AAI44032.1.
CCDSiCCDS43120.1.
RefSeqiNP_001078920.1. NM_001085451.1.
UniGeneiHs.591294.

3D structure databases

ProteinModelPortaliA1A4G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131532. 1 interaction.
STRINGi9606.ENSP00000373191.

PTM databases

PhosphoSiteiA1A4G5.

Polymorphism and mutation databases

BioMutaiLNP1.

Proteomic databases

MaxQBiA1A4G5.
PaxDbiA1A4G5.
PRIDEiA1A4G5.

Protocols and materials databases

DNASUi348801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383693; ENSP00000373191; ENSG00000206535.
GeneIDi348801.
KEGGihsa:348801.
UCSCiuc003dtx.5. human.

Organism-specific databases

CTDi348801.
GeneCardsiLNP1.
H-InvDBHIX0021851.
HGNCiHGNC:28014. LNP1.
HPAiHPA047926.
neXtProtiNX_A1A4G5.
PharmGKBiPA142671542.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1GM. Eukaryota.
ENOG410Z4TY. LUCA.
GeneTreeiENSGT00390000007797.
HOVERGENiHBG101586.
InParanoidiA1A4G5.
OrthoDBiEOG77Q4Z5.
PhylomeDBiA1A4G5.
TreeFamiTF342726.

Miscellaneous databases

ChiTaRSiLNP1. human.
GenomeRNAii348801.
NextBioi99425.
PROiA1A4G5.

Gene expression databases

BgeeiA1A4G5.
CleanExiHS_LNP1.
ExpressionAtlasiA1A4G5. baseline and differential.
GenevisibleiA1A4G5. HS.

Family and domain databases

InterProiIPR029280. LNP1.
[Graphical view]
PfamiPF15419. LNP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: CHROMOSOMAL TRANSLOCATION WITH NUP98.

Entry informationi

Entry nameiLNP1_HUMAN
AccessioniPrimary (citable) accession number: A1A4G5
Secondary accession number(s): B7ZLT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.