ID   A1A490_HUMAN            Unreviewed;       114 AA.
AC   A1A490;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=CC chemokine receptor 5 {ECO:0000313|EMBL:AAY23359.1};
DE   Flags: Fragment;
GN   Name=CCR5 {ECO:0000313|EMBL:AAY23359.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAY23359.1};
RN   [1] {ECO:0000313|EMBL:AAY23359.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17148978; DOI=10.1097/01.aids.0000254687.86122.fa;
RA   Masquelier C., Servais J.Y., Rusanganwa E., Roman F., Havuga E.,
RA   Servais J., Tuyizere S., Omes C., Karasi J.C., Coruteille O., Karita E.,
RA   Allen S., Schmit J.C., Arendt V.;
RT   "A novel 24-base pair deletion in the coding region of CCR5 in an African
RT   population.";
RL   AIDS 21:111-113(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AY947540; AAY23359.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1A490; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004950; F:chemokine receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF686; C-C CHEMOKINE RECEPTOR TYPE 5; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AAY23359.1};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        94..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          47..114
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         114
FT                   /evidence="ECO:0000313|EMBL:AAY23359.1"
SQ   SEQUENCE   114 AA;  13086 MW;  6726A5C03C850E12 CRC64;
     MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR
     LKSMTDIYLL NLAISDLFFL LTAAQWDFGN TMCQLLTGLY FIGFFSGIFF IILL
//