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A1A3B6 (SYR_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:BAD_1418
OrganismBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]
Taxonomic identifier367928 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000017991

Regions

Motif135 – 14511"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A1A3B6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: DB9E47AD8A93521A

FASTA59664,877
        10         20         30         40         50         60 
MSPEALSELI FNIANTLVSE GKAGTLTADL IPPQAKFAVM RPKDRAHGDW ASNAAMQLAK 

        70         80         90        100        110        120 
KAGMKPRDLA ELFAAELTNA DGIKSVEVAG PGFINITLDS ASAAAVVDTV LEAGSDYGKN 

       130        140        150        160        170        180 
DHLSGKTLNL EFVSANPTGP IHIGGTRWAA VGDSMARVLE ANGAKVVREY YFNDHGEQIN 

       190        200        210        220        230        240 
RFAKSLVAAA HGEETPIDGY KGAYIDEIAK RVIDEANADG VDVLSLPRVD GGADQDGNPL 

       250        260        270        280        290        300 
GEGDSEQREE FRKRAVPMMF DEIQRSMKNF RVNFDVWFHE NSLYSDGEVD QAIADLRARG 

       310        320        330        340        350        360 
DIFEKDGATW FESTKHGDDK DRVIIKSDGN YAYFAADIAY YRNKRHRETN PADVAIYMLG 

       370        380        390        400        410        420 
ADHHGYIGRM MAMCEAFGDK PGENMQILIG QLVNVMKDGK AVRMSKRAGN VVTIDDLTDA 

       430        440        450        460        470        480 
IGVDASRYSL ARTDYNSPVD IDLNLLSSHS NENPVYYVQY AHARSCNVDR NAAAAGITYE 

       490        500        510        520        530        540 
GADVSLLDTT ADGEVLAALA QWPALLREAG DLRAPHRVAH YLEDLAATYH KWYNVERVVP 

       550        560        570        580        590 
MELTDPEARG EQADAIRIAK APEPARAAAR LKLNDAVKTV IAEGLDLLGV TAPDKM 

« Hide

References

[1]"Bifidobacterium adolescentis complete genome sequence."
Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009256 Genomic DNA. Translation: BAF40199.1.
RefSeqYP_910281.1. NC_008618.1.

3D structure databases

ProteinModelPortalA1A3B6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING367928.BAD_1418.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF40199; BAF40199; BAD_1418.
GeneID4557397.
KEGGbad:BAD_1418.
PATRIC21102285. VBIBifAdo27973_1497.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycBADO367928:GHPT-1474-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_BIFAA
AccessionPrimary (citable) accession number: A1A3B6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries