Reviewed, UniProtKB/Swiss-Prot A1A3B6 (SYR_BIFAA)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	BAD_1418

Organism

Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083) [Complete proteome] [HAMAP]

Taxonomic identifier

367928 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00123
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_1000017991
Regions
	Motif	135 – 145	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A1A3B6-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: DB9E47AD8A93521A	FASTA	596	64,877
	10 20 30 40 50 60 MSPEALSELI FNIANTLVSE GKAGTLTADL IPPQAKFAVM RPKDRAHGDW ASNAAMQLAK 70 80 90 100 110 120 KAGMKPRDLA ELFAAELTNA DGIKSVEVAG PGFINITLDS ASAAAVVDTV LEAGSDYGKN 130 140 150 160 170 180 DHLSGKTLNL EFVSANPTGP IHIGGTRWAA VGDSMARVLE ANGAKVVREY YFNDHGEQIN 190 200 210 220 230 240 RFAKSLVAAA HGEETPIDGY KGAYIDEIAK RVIDEANADG VDVLSLPRVD GGADQDGNPL 250 260 270 280 290 300 GEGDSEQREE FRKRAVPMMF DEIQRSMKNF RVNFDVWFHE NSLYSDGEVD QAIADLRARG 310 320 330 340 350 360 DIFEKDGATW FESTKHGDDK DRVIIKSDGN YAYFAADIAY YRNKRHRETN PADVAIYMLG 370 380 390 400 410 420 ADHHGYIGRM MAMCEAFGDK PGENMQILIG QLVNVMKDGK AVRMSKRAGN VVTIDDLTDA 430 440 450 460 470 480 IGVDASRYSL ARTDYNSPVD IDLNLLSSHS NENPVYYVQY AHARSCNVDR NAAAAGITYE 490 500 510 520 530 540 GADVSLLDTT ADGEVLAALA QWPALLREAG DLRAPHRVAH YLEDLAATYH KWYNVERVVP 550 560 570 580 590 MELTDPEARG EQADAIRIAK APEPARAAAR LKLNDAVKTV IAEGLDLLGV TAPDKM

References

[1]	"Bifidobacterium adolescentis complete genome sequence." Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP009256 Genomic DNA. Translation: BAF40199.1.
RefSeq	YP_910281.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1A3B6.
Genome annotation databases
GeneID	4557397.
GenomeReviews	Gene locus BAD_1418 in contig AP009256_GR.
KEGG	bad:BAD_1418.
NMPDR	fig|1680.3.peg.1035.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ADHHGYV.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_BIFAA

Accession

Primary (citable) accession number: A1A3B6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)