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A1A2J2 (THIM_BIFAA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:BAD_1144
OrganismBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) [Complete proteome] [HAMAP]
Taxonomic identifier367928 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383821

Sites

Binding site571Substrate; via amide nitrogen By similarity
Binding site1321ATP By similarity
Binding site1961ATP By similarity
Binding site2231Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A1A2J2 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 273D246DFB4B5DA0

FASTA29430,201
        10         20         30         40         50         60 
MSDDPSTNDA LGTLRAAIKQ AVTDVRGQTP LAQSFTNFVT INLVANAQLA AGGTAAMSYL 

        70         80         90        100        110        120 
PDDVIATAEI AGSNYINVGT LLPFFKNALP EIARKLHENG KTWVLDPVAA GIGETRTAIL 

       130        140        150        160        170        180 
ESFRDVPPTI VRGNASEIIA LDAMWGLADA DSTTPATRPA GVEAVDEVDA AVDAAKRLAR 

       190        200        210        220        230        240 
HLAKRSPVGA GAVAVSGAVD LVTDGERTFR LPGGSAMMTK ITGAGCSLGG VTATYLAVAE 

       250        260        270        280        290 
PLVAALAASL LYDRASEIAE VKSDGPGSFQ VALLDALWNV TADQVAASDI IETN 

« Hide

References

[1]"Bifidobacterium adolescentis complete genome sequence."
Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S., Tanaka K., Watanabe K.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15703 / DSM 20083 / NCTC 11814 / E194a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009256 Genomic DNA. Translation: BAF39925.1.
RefSeqYP_910007.1. NC_008618.1.

3D structure databases

ProteinModelPortalA1A2J2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING367928.BAD_1144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF39925; BAF39925; BAD_1144.
GeneID4557641.
KEGGbad:BAD_1144.
PATRIC21101725. VBIBifAdo27973_1226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMANACTQLA.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycBADO367928:GHPT-1191-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_BIFAA
AccessionPrimary (citable) accession number: A1A2J2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways