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Protein

LexA repressor

Gene

lexA

Organism
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181For autocatalytic cleavage activityUniRule annotation1
Active sitei218For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi64 – 84H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Repressor
Biological processDNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation

Protein family/group databases

MEROPSiS24.001

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
Ordered Locus Names:BAD_1115
OrganismiBifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
Taxonomic identifieri367928 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000008702 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003227151 – 257LexA repressorAdd BLAST257

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei146 – 147Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavage

Proteomic databases

PRIDEiA1A2G3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi367928.BAD_1115

Structurei

3D structure databases

ProteinModelPortaliA1A2G3
SMRiA1A2G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DS7 Bacteria
COG1974 LUCA
HOGENOMiHOG000232168
KOiK01356
OMAiRQMMQAM
OrthoDBiPOG091H029U

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00015 LexA, 1 hit
InterProiView protein in InterPro
IPR006200 LexA
IPR036286 LexA/Signal_pep-like_sf
IPR006199 LexA_DNA-bd_dom
IPR006197 Peptidase_S24_LexA
IPR015927 Peptidase_S24_S26A/B/C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01726 LexA_DNA_bind, 1 hit
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00726 LEXASERPTASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR00498 lexA, 1 hit

Sequencei

Sequence statusi: Complete.

A1A2G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDFIGVSRY ASKELRKEPI VSTIPFTPKK SDERPDESTL TDRQRKVLDA
60 70 80 90 100
IKTHLAKQGF APSFREIGEA AGLKSPSSVK HQLQVLDEKG FIRMNANKGR
110 120 130 140 150
AIEVVNLNDE EPNGKVAQVI PFPSQDDACG SIMASHDVPL VGRIAAGVPI
160 170 180 190 200
TAEQHVDDVM RLPERLTGTG NLFMLEVHGD SMIDAAICDG DFVVVREQNS
210 220 230 240 250
AENGDIVAAL LDDEATVKTF RKDHGHVWLI PHNPAYSPID GTHAEIMGKV

VTVLRKI
Length:257
Mass (Da):28,169
Last modified:January 23, 2007 - v1
Checksum:i413955312B4982DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009256 Genomic DNA Translation: BAF39896.1
RefSeqiWP_003810781.1, NC_008618.1

Genome annotation databases

EnsemblBacteriaiBAF39896; BAF39896; BAD_1115
GeneIDi4556287
KEGGibad:BAD_1115

Similar proteinsi

Entry informationi

Entry nameiLEXA_BIFAA
AccessioniPrimary (citable) accession number: A1A2G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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